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Gch1 GTP cyclohydrolase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29244, updated on 10-Sep-2014
Official Symbol
Gch1provided by RGD
Official Full Name
GTP cyclohydrolase 1provided by RGD
Primary source
RGD:61992
See related
Ensembl:ENSRNOG00000011039
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Gch
Summary
an enzyme for tetrahydrobiopterin (BH(4)) synthesis; may mediate cell death of striatal neuronal and non-neuronal cells [RGD, Feb 2006]
See Gch1 in MapViewer
Location:
15p14
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23935011..23968971, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (27876253..27910213, complement)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693376 Neighboring gene sterile alpha motif domain containing 4A Neighboring gene uncharacterized LOC102548428 Neighboring gene WD repeat and HMG-box DNA binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

  • Homologs of the Gch1 gene: The Gch1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs from Annotation Pipeline: 104 organisms have orthologs with human gene GCH1
  • Map Viewer (Human, Mouse)

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTP cyclohydrolase I activity IDA
Inferred from Direct Assay
more info
PubMed 
GTP cyclohydrolase I activity ISO
Inferred from Sequence Orthology
more info
 
NOT GTP cyclohydrolase I activity ISO
Inferred from Sequence Orthology
more info
 
GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
coenzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
7,8-dihydroneopterin 3'-triphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP catabolic process IEA
Inferred from Electronic Annotation
more info
 
GTP catabolic process ISO
Inferred from Sequence Orthology
more info
 
dihydrobiopterin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling posture IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling posture ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
pteridine-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of lung blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of lung blood pressure ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
NOT response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to pain IDA
Inferred from Direct Assay
more info
PubMed 
response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
GTP cyclohydrolase 1
Names
GTP cyclohydrolase 1
GTP-CH-I
GTP cyclohydrolase I
NP_077332.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024356.1NP_077332.1  GTP cyclohydrolase 1 precursor

    See proteins identical to NP_077332.1

    Status: PROVISIONAL

    Source sequence(s)
    M58364
    UniProtKB/Swiss-Prot
    P22288
    Related
    ENSRNOP00000014821, ENSRNOT00000014821
    Conserved Domains (1) summary
    cd00642
    Location:57241
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 

    Range
    23935011..23968971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000083.1 

    Range
    20799206..20832598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)