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Neu2 sialidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29204, updated on 16-Dec-2014
Official Symbol
Neu2provided by RGD
Official Full Name
sialidase 2provided by RGD
Primary source
RGD:3164
See related
Ensembl:ENSRNOG00000016962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
cytosolic enzyme that cleaves sialic acid; involved in the degradation of glycolipids and glycoproteins [RGD, Feb 2006]
See Neu2 in MapViewer
Location:
9q36
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94702095..94724903)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (94396233..94444063)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene LOC363276 Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene uncharacterized LOC102552946 Neighboring gene autophagy related 16-like 1 (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC108717

Gene Ontology Provided by RGD

Function Evidence Code Pubs
exo-alpha-(2->3)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-(2->3)-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
exo-alpha-(2->3)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-(2->8)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 
ganglioside catabolic process ISO
Inferred from Sequence Orthology
more info
 
ganglioside catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
 
oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
 
oligosaccharide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
sialidase-2
Names
sialidase-2
neuraminidase 2
cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
NP_058826.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017130.2NP_058826.2  sialidase-2

    See proteins identical to NP_058826.2

    Status: VALIDATED

    Source sequence(s)
    AABR07068277, BC091154
    UniProtKB/TrEMBL
    Q5BK97
    Related
    ENSRNOP00000022818, ENSRNOT00000022818
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 

    Range
    94702095..94724903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245364.1XP_006245426.1  

    See proteins identical to XP_006245426.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  2. XM_008767210.1XP_008765432.1  

    See proteins identical to XP_008765432.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  3. XM_008767209.1XP_008765431.1  

    See proteins identical to XP_008765431.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  4. XM_006245363.2XP_006245425.1  

    See proteins identical to XP_006245425.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  5. XM_006245365.2XP_006245427.1  

    See proteins identical to XP_006245427.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  6. XM_006245362.2XP_006245424.1  

    See proteins identical to XP_006245424.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  7. XM_008767211.1XP_008765433.1  

    See proteins identical to XP_008765433.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain
  8. XM_006245361.2XP_006245423.1  

    See proteins identical to XP_006245423.1

    UniProtKB/TrEMBL
    Q5BK97
    Conserved Domains (2) summary
    cd00260
    Location:13367
    Sialidase; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold ...
    pfam13088
    Location:33345
    BNR_2; BNR repeat-like domain

Alternate Rn_Celera

Genomic

  1. AC_000077.1 

    Range
    85673821..85677037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)