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Vtn vitronectin [ Rattus norvegicus (Norway rat) ]

Gene ID: 29169, updated on 26-May-2016
Official Symbol
Vtnprovided by RGD
Official Full Name
vitronectinprovided by RGD
Primary source
RGD:3967
See related
Ensembl:ENSRNOG00000010031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Vn; Aa1018
Summary
may act as a cofactor for plasminogen activator inhibitor 1 (PAI-1) inhibition of thrombin [RGD, Feb 2006]
Orthologs
Location:
10q25
Exon count:
8
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65767960..65771040)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (65872580..65875660, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 46 member 1 Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene SEBOX homeobox Neighboring gene transmembrane protein 199

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC124961

Gene Ontology Provided by RGD

Function Evidence Code Pubs
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi lumen IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
blood microparticle IEA
Inferred from Electronic Annotation
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019156.2NP_062029.2  vitronectin precursor

    See identical proteins and their annotated locations for NP_062029.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105821
    UniProtKB/TrEMBL
    Q3KR94
    Related
    ENSRNOP00000046415, ENSRNOT00000039954
    Conserved Domains (2) summary
    cd00094
    Location:152473
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01033
    Location:2063
    Somatomedin_B; Somatomedin B domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    65767960..65771040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    62371307..62374387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)