Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like [Rattus norvegicus] - Gene

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Summary

Official Symbol: Nedd4lprovided by RGD
Official Full Name: neural precursor cell expressed, developmentally down-regulated 4-likeprovided by RGD
Primary source: RGD:735047
See related: Ensembl:ENSRNOG00000017610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: MGC105877
Summary: mouse homolog appears to be involved in binding and regulating the amiloride-sensitive epithelial sodium channel which plays a role in sodium homeostasis and control of blood volume and blood pressure [RGD, Feb 2006]

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Genomic context

Location :: 18q12.1

Sequence :: Chromosome: 18; NC_005117.2 (61134242..61477040)

See Nedd4l in MapViewer

Chromosome 18 - NC_005117.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ENaC and Nedd4-2 are involved in the transition from lung fluid secretion to fluid absorption near term and at birth.
Title: Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis.
both Akt and Sgk are components of an insulin signaling pathway that increases Na(+) absorption by up-regulating membrane expression of ENaC via a regulatory system that involves inhibition of Nedd4-2
Title: Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2.
These findings suggested that Nedd4L gene products were involved in the development of salt-sensitive hypertension.
Title: Transcriptional diversity and expression of NEDD4L gene in distal nephron.
Sgk1-dependent phosphorylation of Nedd4-2 is part of the aldosterone response in kidney cortical collecting ducts
Title: Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:253555	BioGRID:106819	APBB1		BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:253555	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
sodium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
negative regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
response to metal ion	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase NEDD4-like

Names: E3 ubiquitin-protein ligase NEDD4-like; neural precursor cell expressed, developmentally down-regulated gene 4-like

NP_001008301.2

EC 6.3.2.-

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008300.2 → NP_001008301.2 E3 ubiquitin-protein ligase NEDD4-like

Status: PROVISIONAL

Source sequence(s)

CH473971

Related

ENSRNOP00000023890, ENSRNOT00000023890

Conserved Domains (4) summary

cd00078
Location:606 – 960
Blast Score: 1137

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:488 – 517
Blast Score: 133

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04033
Location:8 – 140
Blast Score: 651

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00119
Location:630 – 959
Blast Score: 1276

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005117.2 Reference assembly (based on RGSC_v3.4)

Range

61134242..61477040

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000086.1 Alternate assembly (Rn_Celera)

Range

56529040..56853871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473971.1	EDM14676.1
		EDM14677.1
		EDM14678.1
		EDM14679.1
		EDM14680.1
mRNA	BC061798.1	AAH61798.1
mRNA	BC086371.1	AAH86371.1
mRNA	GQ160815.1	ADD16471.1	DSS
mRNA	GQ160816.1	ADD16472.1	LEW