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BRD7 bromodomain containing 7 [ Homo sapiens (human) ]

Gene ID: 29117, updated on 26-May-2016
Official Symbol
BRD7provided by HGNC
Official Full Name
bromodomain containing 7provided by HGNC
Primary source
HGNC:HGNC:14310
See related
Ensembl:ENSG00000166164 Vega:OTTHUMG00000133170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP75; NAG4; CELTIX1
Summary
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Orthologs
Location:
16q12
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (50319018..50368966, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50352929..50402845, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927250 Neighboring gene PAP associated domain containing 5 Neighboring gene adenylate cyclase 7 Neighboring gene microRNA 6771 Neighboring gene uncharacterized LOC105371248 Neighboring gene uncharacterized LOC105371250

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
BAF-type complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
bromodomain-containing protein 7
Names
75 kDa bromodomain protein
protein CELTIX-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023418.1 RefSeqGene

    Range
    5001..54917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173984.2NP_001167455.1  bromodomain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001167455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007493, AF152604, AF213969, AW615116
    Consensus CDS
    CCDS54007.1
    UniProtKB/Swiss-Prot
    Q9NPI1
    Related
    ENSP00000378181, OTTHUMP00000164223, ENST00000394689, OTTHUMT00000256875
    Conserved Domains (2) summary
    cd05513
    Location:135232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:286535
    DUF3512; Domain of unknown function (DUF3512)
  2. NM_013263.4NP_037395.2  bromodomain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_037395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AC007493, AF152604, AW615116, DA645362
    Consensus CDS
    CCDS10742.1
    UniProtKB/Swiss-Prot
    Q9NPI1
    Related
    ENSP00000378180, OTTHUMP00000164222, ENST00000394688, OTTHUMT00000256874
    Conserved Domains (2) summary
    cd05513
    Location:135232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:286534
    DUF3512; Domain of unknown function (DUF3512)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    50319018..50368966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523049.1XP_011521351.1  

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:303515
    DUF3512; Domain of unknown function (DUF3512)
  2. XM_011523048.1XP_011521350.1  

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:303516
    DUF3512; Domain of unknown function (DUF3512)
  3. XM_011523046.1XP_011521348.1  

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:303552
    DUF3512; Domain of unknown function (DUF3512)
  4. XM_011523047.1XP_011521349.1  

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:303551
    DUF3512; Domain of unknown function (DUF3512)
  5. XM_011523050.1XP_011521352.1  

    Conserved Domains (2) summary
    pfam12024
    Location:84333
    DUF3512; Domain of unknown function (DUF3512)
    cl02556
    Location:130
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

RNA

  1. XR_933291.1 RNA Sequence

  2. XR_933290.1 RNA Sequence

  3. XR_933289.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    51760032..51809939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)