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    FHOD1 formin homology 2 domain containing 1 [ Homo sapiens ]

    Gene ID: 29109, updated on 11-May-2012
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    Summary

    Official Symbol
    FHOD1provided by HGNC
    Official Full Name
    formin homology 2 domain containing 1provided by HGNC
    Primary source
    HGNC:17905
    See related
    Ensembl:ENSG00000135723; HPRD:06049; MIM:606881; Vega:OTTHUMG00000137521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FHOS
    Summary
    This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    16q22
    Sequence :
    Chromosome: 16; NC_000016.9 (67263292..67281425, complement)
    See FHOD1 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 29 Neighboring gene transmembrane protein 208 Neighboring gene solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Jurmeister S, et al. Mol Cell Biol, 2012 Feb. PMID 22144583.
    2. G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets. Thomas SG, et al. J Thromb Haemost, 2011 Aug. PMID 21605332.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype. Staus DP, et al. Arterioscler Thromb Vasc Biol, 2011 Feb. PMID 21106951.
    5. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples.
      Title: MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
    2. Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
      Title: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
    3. FHOD1 is a critical regulator of smooth muscle cell phenotype and is regulated by ROCK-dependent phosphorylation.
      Title: Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype.
    4. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
      Title: The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
    5. Mutation of one residue in the predicted DAD-interaction surface efficiently activates FHOD1 in cells.
      Title: The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.
    6. FHOD1 is activated through phosphorylation by rho-dependent protein kinase (ROCK)and has an important function in stress fibre formation in vascular endothelial cells
      Title: The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
    7. In this study, the N-terminal region (residues 1-339) of the human formin homology domain-containing protein 1 (FHOD1) was purified and crystallized.
      Title: Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.
    8. This study demonstrates FHOD1 is cleaved by caspase-3 at the SVPD(616) site during apoptosis and the C-terminal FHOD1 cleavage product has the ability to inhibit RNA polymerase I transcription.
      Title: Caspase-3 cleaves the formin-homology-domain-containing protein FHOD1 during apoptosis to generate a C-terminal fragment that is targeted to the nucleolus.
    9. These novel data demonstrate that FHOD1-ERK MAP kinase interaction regulates key aspects of FHOD1 biology.
      Title: The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway.
    10. Fhos directly binds to F-actin via the N-terminal region, forms a homotypic complex via the FH2 domain to organize actin cytoskeleton
      Title: Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation.
    Submit: New GeneRIF Correction See all (15)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_037373.1 NP_005566.1 LNPEP    BIND  PubMed IRAP interacts with FHOS. This interaction was modeled on a demonstrated interaction between rat IRAP and human FHOS. 
    NP_037373.1 NP_444252.1 PFN2    BIND  PubMed PFN IIa interacts with FHOS. 
    Q9Y613 P68133 ACTA1    HPRD  PubMed  
    Q9Y613 P63261 ACTG1    HPRD  PubMed  
    Q9Y613 P20023 CR2    HPRD  PubMed  
    Q9Y613 Q96B26 EXOSC8    HPRD  PubMed  
    Q9Y613 Q9Y613 FHOD1    HPRD  PubMed  
    Q9Y613 Q9UIQ6 LNPEP    HPRD  PubMed  
    Q9Y613 P35080 PFN2    HPRD  PubMed  
    Q9Y613 P14619 PRKG1    HPRD  PubMed  
    Q9Y613 P63000 RAC1    HPRD  PubMed  
    Q9Y613 Q99942 RNF5    HPRD  PubMed  
    Q9Y613 Q9ULU4 ZMYND8    HPRD  PubMed  
    BioGRID:118877 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118877 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:116468 EXOSC8    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:118877 FHOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:118877 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:110196 LNPEP    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:116691 NCOA6    BioGRID  PubMed Two-hybrid 
    NP_444252.1 PFN2    BIND  PubMed PFN IIa interacts with FHOS78. 
    BioGRID:118877 BioGRID:111238 PFN2    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:111464 PPARG    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:111817 RAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:118877 BioGRID:111839 RANBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:111975 RNF5    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118877 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
    BioGRID:118877 BioGRID:117146 ZMYND8    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    bleb IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    FH1/FH2 domain-containing protein 1
    Names
    FH1/FH2 domain-containing protein 1
    formin homolog overexpressed in spleen 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029672.1 RefSeqGene

      Range
      5001..23134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013241.2 → NP_037373.2  FH1/FH2 domain-containing protein 1

      Status: REVIEWED

      Source sequence(s)
      AA609867, AB041046, BC033084, CN302043
      Consensus CDS
      CCDS10834.1
      UniProtKB/Swiss-Prot
      Q9Y613
      Related
      ENSP00000258201, OTTHUMP00000174818, ENST00000258201, OTTHUMT00000268844
      Conserved Domains (2) summary
      smart00498
      Location:621 – 1027
      Blast Score: 804
      FH2; Formin Homology 2 Domain
      pfam02181
      Location:618 – 988
      Blast Score: 752
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      67263292..67281425, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      53136470..53154499, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC040160.4 (91396..109433) None
    genomic CH471092.1 EAW83109.1
      EAW83110.1
      EAW83111.1
      EAW83112.1
      EAW83113.1
    mRNA AA609867.1 None
    mRNA AB041046.1 BAD06250.1
    mRNA AB209584.1 BAD92821.1
    mRNA AF113615.1 AAD39906.1
    mRNA AK025992.1 None
    mRNA AK301157.1 BAG62747.1
    mRNA AK304232.1 BAG65101.1
    mRNA AY192154.1 AAO38757.1
    mRNA BC033084.1 AAH33084.1
    mRNA CN302043.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y613.3 GenPept UniProtKB/Swiss-Prot:Q9Y613
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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