Format

Send to:

Choose Destination

SCG3 secretogranin III [ Homo sapiens (human) ]

Gene ID: 29106, updated on 8-May-2016
Official Symbol
SCG3provided by HGNC
Official Full Name
secretogranin IIIprovided by HGNC
Primary source
HGNC:HGNC:13707
See related
Ensembl:ENSG00000104112 HPRD:11538; MIM:611796; Vega:OTTHUMG00000131748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGIII
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Orthologs
Location:
15q21
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (51681353..51721026)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51973550..52013223)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Dmx like 2 Neighboring gene uncharacterized LOC105370816 Neighboring gene uncharacterized LOC105370817 Neighboring gene LysM domain containing 2 Neighboring gene tropomodulin 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
NHGRI GWA Catalog
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ90833

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013214.1 RefSeqGene

    Range
    5001..44674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165257.1NP_001158729.1  secretogranin-3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the alternate exon containing the translation intiation site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC020892, AF453583, AK296466, BI552493
    Consensus CDS
    CCDS53947.1
    UniProtKB/Swiss-Prot
    Q8WXD2
    Related
    ENSP00000445205, OTTHUMP00000248749, ENST00000542355, OTTHUMT00000419215
    Conserved Domains (1) summary
    pfam15467
    Location:1236
    SGIII; Secretogranin-3
  2. NM_013243.3NP_037375.2  secretogranin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_037375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020892, AF453583, BI552493
    Consensus CDS
    CCDS10142.1
    UniProtKB/Swiss-Prot
    Q8WXD2
    Related
    ENSP00000220478, OTTHUMP00000162544, ENST00000220478, OTTHUMT00000254670
    Conserved Domains (1) summary
    pfam15467
    Location:16468
    SGIII; Secretogranin-3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    51681353..51721026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    52091646..52131257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)