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SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase [ Homo sapiens (human) ]

Gene ID: 29101, updated on 8-May-2016
Official Symbol
SSU72provided by HGNC
Official Full Name
SSU72 homolog, RNA polymerase II CTD phosphataseprovided by HGNC
Primary source
HGNC:HGNC:25016
See related
Ensembl:ENSG00000160075 HPRD:13712; Vega:OTTHUMG00000000576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC182; PNAS-120
Orthologs
Location:
1p36.33
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (1541673..1574882, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1477053..1510262, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 3A Neighboring gene transmembrane protein 240 Neighboring gene uncharacterized LOC105378586 Neighboring gene chromosome 1 open reading frame 233

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of SSU72 RNA polymerase II CTD phosphatase homolog by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat recruits Ssu72 together with P-TEFb to the integrated HIV-1 proviral promoter in TNF-alpha treated 2D10 T cells PubMed
tat Ssu72 cooperates with the Tat/P-TEFb complex to create a CTD that is highly enriched in S2 phosphorylation PubMed
tat Ssu72 stimulates HIV-1 Tat transactivation in a C-terminal domain phosphatase-dependent manner PubMed
tat HIV-1 Tat interacts directly with the human Ssu72 CTD phosphatase and both the N-terminal and the C-terminal domains of Tat, and the coiled-coil domain of Ssu72 are required for the direct interaction between Tat and Ssu72 PubMed

Go to the HIV-1, Human Interaction Database

  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CTD phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation of RNA polymerase II C-terminal domain IDA
Inferred from Direct Assay
more info
PubMed 
mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Names
CTD phosphatase SSU72
NP_054907.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014188.2NP_054907.1  RNA polymerase II subunit A C-terminal domain phosphatase SSU72

    See identical proteins and their annotated locations for NP_054907.1

    Status: VALIDATED

    Source sequence(s)
    AF161530, AJ276409, CF594026
    Consensus CDS
    CCDS32.1
    UniProtKB/Swiss-Prot
    Q9NP77
    Related
    ENSP00000291386, OTTHUMP00000000597, ENST00000291386, OTTHUMT00000001366
    Conserved Domains (1) summary
    pfam04722
    Location:4194
    Ssu72; Ssu72-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    1541673..1574882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    1464275..1497415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)