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    UBE2T ubiquitin-conjugating enzyme E2T (putative) [ Homo sapiens ]

    Gene ID: 29089, updated on 20-May-2012
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    Summary

    Official Symbol
    UBE2Tprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2T (putative)provided by HGNC
    Primary source
    HGNC:25009
    Locus tag
    HSPC150
    See related
    Ensembl:ENSG00000077152; HPRD:13704; MIM:610538; Vega:OTTHUMG00000041392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG50; HSPC150
    Summary
    The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    1q32.1
    Sequence :
    Chromosome: 1; NC_000001.10 (202300785..202311094, complement)
    See UBE2T in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, V, pseudogene Neighboring gene leucine-rich repeat containing G protein-coupled receptor 6 Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene cytochrome c, somatic pseudogene 4 Neighboring gene FK506 binding protein 8, 38kDa pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T. Ramaekers CH, et al. Radiother Oncol, 2011 Oct. PMID 21722982.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway
      Title: Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
    2. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex.
      Title: Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
    3. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair.
      Title: FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
    4. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination.
      Title: Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
    5. UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype.
      Title: Elevated expression of UBE2T in lung cancer tumors and cell lines.
    6. UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway.
      Title: UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:118858 BioGRID:106764 AMFR    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:115694 ARIH2    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:118858 BioGRID:120429 FANCL    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:118858 BioGRID:128798 LNX2    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:120105 MARCH5    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:116890 MGRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:113497 PCGF2    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:122731 RNF128    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:129106 RNF144B    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:111974 RNF4    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118858 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:118858 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
    • Fanconi Anemia pathway, organism-specific biosystem (from REACTOME)
      Fanconi Anemia pathway, organism-specific biosystemFanconi anemia (FA) is a genetic disease of genome instability characterized by congenital skeletal defects, aplastic anemia, susceptibility to leukemias, and cellular sensitivity to DNA damaging age...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein K27-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein K29-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein K6-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 T
    Names
    ubiquitin-conjugating enzyme E2 T
    ubiquitin-protein ligase T
    ubiquitin carrier protein T
    ubiquitin conjugating enzyme
    cell proliferation-inducing gene 50 protein
    HSPC150 protein similar to ubiquitin-conjugating enzyme
    NP_054895.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014176.3 → NP_054895.1  ubiquitin-conjugating enzyme E2 T

      Status: VALIDATED

      Source sequence(s)
      AK000504, BG776416
      Consensus CDS
      CCDS1425.1
      UniProtKB/Swiss-Prot
      Q9NPD8
      Related
      ENSP00000356243, OTTHUMP00000038808, ENST00000367274, OTTHUMT00000099163
      Conserved Domains (1) summary
      cd00195
      Location:5 – 147
      Blast Score: 421
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      202300785..202311094, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      173466879..173477184, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL356953.17 CAI15933.1
    genomic CH471067.1 EAW91411.1
      EAW91412.1
      EAW91413.1
      EAW91414.1
      EAW91415.1
    genomic CS063588.1 CAI84529.1
    mRNA AB032931.1 BAA93711.1
    mRNA AF160215.1 AAF67016.1
    mRNA AF161499.1 AAF29114.1
    mRNA AK000504.1 BAA91211.1
    mRNA AY542309.1 AAT08178.1
    mRNA BC004152.2 AAH04152.1
    mRNA BC019284.1 AAH19284.1
    mRNA BG776416.1 None
    other-genetic DQ892729.2 ABM83655.1
    other-genetic DQ895975.2 ABM86901.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NPD8.1 GenPept UniProtKB/Swiss-Prot:Q9NPD8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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