NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [ Homo sapiens ]

Gene ID: 2908, updated on 20-May-2012

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Summary

Official Symbol: NR3C1provided by HGNC
Official Full Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)provided by HGNC
Primary source: HGNC:7978
See related: Ensembl:ENSG00000113580; HPRD:00679; MIM:138040; Vega:OTTHUMG00000129677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GR; GCR; GRL; GCCR
Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

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Genomic context

Location :: 5q31.3

Sequence :: Chromosome: 5; NC_000005.9 (142657496..142815077, complement)

See NR3C1 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRHR1, FKBP5 and NR3C1 gene variants are not associated with offspring depression symptoms from mothers with recurrent depression
Title: Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants.
Variable expression of GR in pituitary/adrenal cortex may contribute to variation in hypothalamic-pituitary-adrenal axis function; genetic variability in GR may contribute to pituitary/adrenal tumors or Cushing disease/syndrome. [REVIEW]
Title: The glucocorticoid receptor and its expression in the anterior pituitary and the adrenal cortex: a source of variation in hypothalamic-pituitary-adrenal axis function; implications for pituitary and adrenal tumors.
NFkappaB and glucocorticoid receptor activity in steroid resistance.
Title: NFκB and glucocorticoid receptor activity in steroid resistance.
Modulation of SRp levels altered the GRbeta/alpha ratio that correlated with DEX responsiveness.
Title: Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
Higher cortisol levels are associated with lower femoral neck BMD in elderly women. The G allele of the 9beta polymorphism was associated with lower serum cortisol levels in women
Title: Serum fasting cortisol in relation to bone, and the role of genetic variations in the glucocorticoid receptor.
Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome
Title: Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.
This study contributes to the growing evidence for a role of the glucocorticoid receptor gene (NR3C1) in vulnerability to mood disorders, and BPD in particular.
Title: Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population.
Data indicate that polycystic ovary syndrome is associated with up-regulation of glucocorticoid receptor along with hyper-suppression of HPA axis (i.e., increased sensitivity to suppression by dexamethasone), and impairment of feedback inhibition.
Title: Hypothalamic-pituitary-adrenocortical axis hypersensitivity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome.
Polymorphisms of the GR-gene are factors which influence some clinical manifestations of bipolar disorder, with respect to seasonal pattern of (hypo)mania and age of onset.
Title: Glucocorticoid and mineralocorticoid receptor polymorphisms and clinical characteristics in bipolar disorder patients.
NRIP enhances HPV 16 gene expression via interaction with either GR or viral E2.
Title: NRIP enhances HPV gene expression via interaction with either GR or E2.

Submit: New GeneRIF Correction See all (340)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed
	vpr	HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway	PubMed
	vpr	HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation	PubMed
	vpr	HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters	PubMed
	vpr	Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway	PubMed
	vpr	HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway	PubMed
	vpr	Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr	PubMed
	vpr	Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity	PubMed
	vpr	HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000167.1	NP_005047.1	KDM5A	BIND	PubMed	Rbp2 interacts with GR. This interaction was modeled on a demonstrated interaction between human Rbp2 and rat GR.
NP_000167.1	NP_006531.1	NCOA2	BIND	PubMed	GR-alpha interacts with GRIP1.
NP_000167.1	NP_000537.2	TP53	BIND	PubMed	p53 interacts with GR. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and GR from an unspecified species.
P04150	P00813	ADA	HPRD	PubMed
P04150	P10275	AR	HPRD	PubMed
P04150	Q99933	BAG1	HPRD	PubMed
P04150	Calmodulin 1	CALM1	HPRD	PubMed
P04150	P27797	CALR	HPRD	PubMed
P04150	P49715	CEBPA	HPRD	PubMed
P04150	P17676	CEBPB	HPRD	PubMed
P04150	Q3L8U1	CHD9	HPRD	PubMed
P04150	Q7L5N1	COPS6	HPRD	PubMed
P04150	P16220	CREB1	HPRD	PubMed
P04150	Q92793	CREBBP	HPRD	PubMed
P04150	P51398	DAP3	HPRD	PubMed
P04150	IQ motif and WD repeats 1	DCAF6	HPRD	PubMed
P04150	Q8TDD1	DDX54	HPRD	PubMed
P04150	O95905	ECD	HPRD	PubMed
P04150	P14921	ETS1	HPRD	PubMed
P04150	P15036	ETS2	HPRD	PubMed
P04150	Q02790	FKBP4	HPRD	PubMed
P04150	P06241	FYN	HPRD	PubMed
P04150	Q9Y3R0	GRIP1	HPRD	PubMed
P04150	Q00839	HNRNPU	HPRD	PubMed
P04150	P07900	HSP90AA1	HPRD	PubMed
P04150	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P04150	P14735	IDE	HPRD	PubMed
P04150	P38484	IFNGR2	HPRD	PubMed
P04150	P05412	JUN	HPRD	PubMed
P04150	P29375	KDM5A	HPRD	PubMed
P04150	P52292	KPNA2	HPRD	PubMed
P04150	P06239	LCK	HPRD	PubMed
P04150	P28482	MAPK1	HPRD	PubMed
P04150	Q8TD08	MAPK15	HPRD	PubMed
P04150	P45983	MAPK8	HPRD	PubMed
P04150	Q00987	MDM2	HPRD	PubMed
P04150	O60244	MED14	HPRD	PubMed
P04150	P19338	NCL	HPRD	PubMed
P04150	Q15788	NCOA1	HPRD	PubMed
P04150	Q15596	NCOA2	HPRD	PubMed
P04150	Q14686	NCOA6	HPRD	PubMed
P04150	O75376	NCOR1	HPRD	PubMed
P04150	Q9Y618	NCOR2	HPRD	PubMed
P04150	P19838	NFKB1	HPRD	PubMed
P04150	Q00653	NFKB2	HPRD	PubMed
P04150	P24468	NR2F2	HPRD	PubMed
P04150	P10588	NR2F6	HPRD	PubMed
P04150	P04150	NR3C1	HPRD	PubMed
P04150	P08235	NR3C2	HPRD	PubMed
P04150	P48552	NRIP1	HPRD	PubMed
P04150	Q9UBC0	ONECUT1	HPRD	PubMed
P04150	P40424	PBX1	HPRD	PubMed
P04150	P28069	POU1F1	HPRD	PubMed
P04150	P14859	POU2F1	HPRD	PubMed
P04150	P09086	POU2F2	HPRD	PubMed
P04150	Q9UBK2	PPARGC1A	HPRD	PubMed
P04150	P17612	PRKACA	HPRD	PubMed
P04150	P78527	PRKDC	HPRD	PubMed
P04150	TBP 1 interacting protein	PSMC3IP	HPRD	PubMed
P04150	Q15185	PTGES3	HPRD	PubMed
P04150	P20962	PTMS	HPRD	PubMed
P04150	P04049	RAF1	HPRD	PubMed
P04150	Q04206	RELA	HPRD	PubMed
P04150	Q9UBS8	RNF14	HPRD	PubMed
P04150	P31947	SFN	HPRD	PubMed
P04150	P12235	SLC25A4	HPRD	PubMed
P04150	P84022	SMAD3	HPRD	PubMed
P04150	P51531	SMARCA2	HPRD	PubMed
P04150	P51532	SMARCA4	HPRD	PubMed
P04150	Q12824	SMARCB1	HPRD	PubMed
P04150	Q92922	SMARCC1	HPRD	PubMed
P04150	Q96GM5	SMARCD1	HPRD	PubMed
P04150	Q969G3	SMARCE1	HPRD	PubMed
P04150	P40763	STAT3	HPRD	PubMed
P04150	P42229	STAT5A	HPRD	PubMed
P04150	P51692	STAT5B	HPRD	PubMed
P04150	P63165	SUMO1	HPRD	PubMed
P04150	Q6EEV6	SUMO4	HPRD	PubMed
P04150	P21579	SYT1	HPRD	PubMed
P04150	P20226	TBP	HPRD	PubMed
P04150	HIC5	TGFB1I1	HPRD	PubMed
P04150	P04637	TP53	HPRD	PubMed
P04150	O15164	TRIM24	HPRD	PubMed
P04150	Q13263	TRIM28	HPRD	PubMed
P04150	Q99816	TSG101	HPRD	PubMed
P04150	P10599	TXN	HPRD	PubMed
P04150	Ubiquitin B	UBB	HPRD	PubMed
P04150	P63279	UBE2I	HPRD	PubMed
P04150	Q04917	YWHAH	HPRD	PubMed
P04150	Q05516	ZBTB16	HPRD	PubMed
BioGRID:109165	BioGRID:106614	ADA	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:115399	ARPC5	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:107049	BAG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:107262	CALR	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:107355	CD3G	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:107479	CEBPA	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:107480	CEBPB	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:107775	CREB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:113587	DAP3	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:107985	DAXX	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:122503	DDX54	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:116450	ECD	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:108415	ETS2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:108578	FKBP4	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:108773	FTH1	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:116995	GRIP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:115330	HDAC6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:109389	HMGB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:109391	HMGB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:109406	HMOX2	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:109420	HNRNPA1	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:109451	HOXB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:35923	HSP82	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:109165	BioGRID:109535	HSPA1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:109561	HSPD1	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:109928	JUN	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:111862	KDM5A	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:110124	LCK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:120905	LRIF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:117264	MAFF	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:111465	MED1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:114699	MED14	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:123607	MED25	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:110594	MSX2	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:110771	NCL	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:115761	NCOA2	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
BioGRID:109165	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:113726	NCOA4	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:116691	NCOA6	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109165	BioGRID:116915	NEDD4L	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:110858	NFKB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:115320	NR2E3	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:112884	NR2F2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:108375	NR2F6	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:109165	NR3C1	BioGRID	PubMed	Co-crystal Structure
BioGRID:109165	BioGRID:110451	NR3C2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:109407	NR4A1	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:113843	NRIP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:109417	ONECUT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:120779	OSGEP	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:111120	PBX1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:114523	PIAS2	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:111384	PML	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:111445	POU1F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:111447	POU2F1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:111448	POU2F2	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:116097	PPARGC1A	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:118945	PSMC3IP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:115952	PTGES3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:111730	PTMS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:250872	Psmc3ip	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:111820	RAD9A	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:111831	RAF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:111837	RAN	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:115359	RANBP9	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109165	BioGRID:115700	RBM14	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:112169	RXRB	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:112316	SET	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109165	BioGRID:109072	SFN	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:112319	SFPQ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:112479	SMARCA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:109165	BioGRID:112483	SMARCC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112486	SMARCD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:112489	SMARCE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:112654	STAT5B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109165	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:112707	SVIL	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:112734	TADA2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:112855	TDG	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:112899	TGFB1I1	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:114333	TRIM24	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109165	BioGRID:113102	TSG101	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:113146	TXN	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109165	BioGRID:113365	YWHAH	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109165	BioGRID:113498	ZBTB16	BioGRID	PubMed	Reconstituted Complex
BioGRID:109165	BioGRID:117573	ZBTB20	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:122933	ZBTB3	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:128736	ZBTB9	BioGRID	PubMed	Two-hybrid
BioGRID:109165	BioGRID:124291	ZNF496	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
chromatin binding	IEA Inferred from Electronic Annotation more info
double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
glucocorticoid receptor activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
steroid binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adrenal gland development	IEA Inferred from Electronic Annotation more info
aging	IEA Inferred from Electronic Annotation more info
anti-apoptosis	IEA Inferred from Electronic Annotation more info
brain development	IEA Inferred from Electronic Annotation more info
cellular response to magnesium ion	IEA Inferred from Electronic Annotation more info
chromatin modification	IEA Inferred from Electronic Annotation more info
chromatin-mediated maintenance of transcription	IEA Inferred from Electronic Annotation more info
circadian rhythm	IEA Inferred from Electronic Annotation more info
gene expression	TAS Traceable Author Statement more info
glucocorticoid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
glucocorticoid metabolic process	IEA Inferred from Electronic Annotation more info
glucocorticoid receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
lung development	IEA Inferred from Electronic Annotation more info
mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
muscle atrophy	IEA Inferred from Electronic Annotation more info
negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
positive regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
positive regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info
regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
response to activity	IEA Inferred from Electronic Annotation more info
response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
response to corticosterone stimulus	IEA Inferred from Electronic Annotation more info
response to insulin stimulus	IEA Inferred from Electronic Annotation more info
response to mercury ion	IEA Inferred from Electronic Annotation more info
response to radiation	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
dendritic spine	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
postsynaptic density	IEA Inferred from Electronic Annotation more info
protein complex	IEA Inferred from Electronic Annotation more info
synaptosome	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: glucocorticoid receptor

Names: glucocorticoid receptor; glucocorticoid nuclear receptor variant 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009062.1 RefSeqGene

Range

5001..162582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000176.2 → NP_000167.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/TrEMBL

F1D8N4

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000377977, OTTHUMP00000160085, ENST00000394464, OTTHUMT00000251880

Conserved Domains (3) summary

cd07076
Location:531 – 777
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 494
Blast Score: 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1345

GCR; Glucocorticoid receptor
NM_001018074.1 → NP_001018084.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/TrEMBL

F1D8N4

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:531 – 777
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 494
Blast Score: 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1345

GCR; Glucocorticoid receptor
NM_001018075.1 → NP_001018085.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/TrEMBL

F1D8N4

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:531 – 777
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 494
Blast Score: 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1345

GCR; Glucocorticoid receptor
NM_001018076.1 → NP_001018086.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, BF966114, X03225

Consensus CDS

CCDS4278.1

UniProtKB/TrEMBL

F1D8N4

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000427672, OTTHUMP00000222855, ENST00000503201, OTTHUMT00000370829

Conserved Domains (3) summary

cd07076
Location:531 – 777
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 494
Blast Score: 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1345

GCR; Glucocorticoid receptor
NM_001018077.1 → NP_001018087.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/TrEMBL

F1D8N4

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000343205, ENST00000343796

Conserved Domains (3) summary

cd07076
Location:531 – 777
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 494
Blast Score: 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1345

GCR; Glucocorticoid receptor
NM_001020825.1 → NP_001018661.1 glucocorticoid receptor isoform beta

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).

Source sequence(s)

AC004782, AC091925, X03348

Consensus CDS

CCDS47298.1

UniProtKB/TrEMBL

E5KQF5

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000387672, OTTHUMP00000222851, ENST00000415690, OTTHUMT00000370825

Conserved Domains (3) summary

cd07172
Location:419 – 494
Blast Score: 477

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1337

GCR; Glucocorticoid receptor

cl11397
Location:531 – 729
Blast Score: 1080

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001024094.1 → NP_001019265.1 glucocorticoid receptor isoform gamma

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).

Source sequence(s)

AC004782, AC091925, U01351

Consensus CDS

CCDS34258.1

UniProtKB/TrEMBL

E5KQF6

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000231509, OTTHUMP00000160084, ENST00000231509, OTTHUMT00000251879

Conserved Domains (3) summary

cd07076
Location:532 – 778
Blast Score: 1350

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:419 – 495
Blast Score: 464

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1347

GCR; Glucocorticoid receptor
NM_001204258.1 → NP_001191187.1 glucocorticoid receptor isoform alpha-B

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:505 – 751
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:393 – 468
Blast Score: 475

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 367
Blast Score: 1348

GCR; Glucocorticoid receptor
NM_001204259.1 → NP_001191188.1 glucocorticoid receptor isoform alpha-C1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:446 – 692
Blast Score: 1348

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:334 – 409
Blast Score: 473

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 308
Blast Score: 1214

GCR; Glucocorticoid receptor
NM_001204260.1 → NP_001191189.1 glucocorticoid receptor isoform alpha-C2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:442 – 688
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:330 – 405
Blast Score: 473

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 304
Blast Score: 1190

GCR; Glucocorticoid receptor
NM_001204261.1 → NP_001191190.1 glucocorticoid receptor isoform alpha-C3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:434 – 680
Blast Score: 1349

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:322 – 397
Blast Score: 472

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 296
Blast Score: 1152

GCR; Glucocorticoid receptor
NM_001204262.1 → NP_001191191.1 glucocorticoid receptor isoform alpha-D1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:216 – 462
Blast Score: 1337

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:104 – 179
Blast Score: 459

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 78
Blast Score: 390

GCR; Glucocorticoid receptor
NM_001204263.1 → NP_001191192.1 glucocorticoid receptor isoform alpha-D2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07076
Location:201 – 447
Blast Score: 1332

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:89 – 164
Blast Score: 458

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 63
Blast Score: 314

GCR; Glucocorticoid receptor
NM_001204264.1 → NP_001191193.1 glucocorticoid receptor isoform alpha-D3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/Swiss-Prot

P04150

Related

ENSP00000404218, ENST00000416954

Conserved Domains (3) summary

cd07076
Location:196 – 442
Blast Score: 1334

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:84 – 159
Blast Score: 457

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 – 58
Blast Score: 279

GCR; Glucocorticoid receptor
NM_001204265.1 → NP_001191194.1 glucocorticoid receptor isoform GR-P

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).

Source sequence(s)

AA737284, AC091925, BF244382, U01351, U25029

UniProtKB/Swiss-Prot

P04150

Conserved Domains (3) summary

cd07172
Location:419 – 494
Blast Score: 472

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 – 393
Blast Score: 1330

GCR; Glucocorticoid receptor

cl11397
Location:531 – 674
Blast Score: 781

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

142657496..142815077, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

137804733..137962312, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004782.1	None
genomic	AC005601.1	AAC34207.1
genomic	AC010284.4	None
genomic	AC091925.3 (18952..153290)	None
genomic	AF304129.1	None
genomic	AF395116.1	None
genomic	AY436590.1	AAQ97180.1
genomic	CH471062.2	EAW61870.1
		EAW61871.1
		EAW61872.1
		EAW61873.1
genomic	CS542423.1	CAM91161.1
genomic	EU332858.1	ABY87547.1
genomic	FB571449.1	CAR95142.1
genomic	FB571451.1	CAR95143.1
genomic	FB571453.1	CAR95144.1
genomic	FB571455.1	CAR95145.1
genomic	FB571457.1	CAR95146.1
genomic	FB571459.1	CAR95147.1
genomic	FB571461.1	CAR95148.1
genomic	HQ205546.1	ADP91134.1
		ADP91135.1
		ADP91136.1
genomic	HQ205547.1	ADP91137.1
		ADP91138.1
		ADP91139.1
genomic	HQ205548.1	ADP91140.1
		ADP91141.1
		ADP91142.1
genomic	HQ205549.1	ADP91143.1
		ADP91144.1
		ADP91145.1
genomic	HQ205550.1	ADP91146.1
		ADP91147.1
		ADP91148.1
genomic	HQ205551.1	ADP91149.1
		ADP91150.1
		ADP91151.1
genomic	HQ205552.1	ADP91152.1
		ADP91153.1
		ADP91154.1
genomic	HQ205553.1	ADP91155.1
		ADP91156.1
		ADP91157.1
genomic	HQ205554.1	ADP91158.1
		ADP91159.1
		ADP91160.1
genomic	HQ205555.1	ADP91161.1
		ADP91162.1
		ADP91163.1
genomic	HQ205556.1	ADP91164.1
		ADP91165.1
		ADP91166.1
genomic	HQ205557.1	ADP91167.1
		ADP91168.1
		ADP91169.1
genomic	HQ205558.1	ADP91170.1
		ADP91171.1
		ADP91172.1
genomic	HQ205559.1	ADP91173.1
		ADP91174.1
		ADP91175.1
genomic	HQ205560.1	ADP91176.1
		ADP91177.1
		ADP91178.1
genomic	HQ205561.1	ADP91179.1
		ADP91180.1
		ADP91181.1
genomic	HQ205562.1	ADP91182.1
		ADP91183.1
		ADP91184.1
genomic	HQ205563.1	ADP91185.1
		ADP91186.1
		ADP91187.1
genomic	HQ205564.1	ADP91188.1
		ADP91189.1
		ADP91190.1
genomic	HQ205565.1	ADP91191.1
		ADP91192.1
		ADP91193.1
genomic	HQ205566.1	ADP91194.1
		ADP91195.1
		ADP91196.1
genomic	HQ205567.1	ADP91197.1
		ADP91198.1
		ADP91199.1
genomic	HQ205568.1	ADP91200.1
		ADP91201.1
		ADP91202.1
genomic	HQ205569.1	ADP91203.1
		ADP91204.1
		ADP91205.1
genomic	HQ205570.1	ADP91206.1
		ADP91207.1
		ADP91208.1
genomic	HQ205571.1	ADP91209.1
		ADP91210.1
		ADP91211.1
genomic	HQ205572.1	ADP91212.1
		ADP91213.1
		ADP91214.1
genomic	HQ205573.1	ADP91215.1
		ADP91216.1
		ADP91217.1
genomic	HQ205574.1	ADP91218.1
		ADP91219.1
		ADP91220.1
genomic	HQ205575.1	ADP91221.1
		ADP91222.1
		ADP91223.1
genomic	HQ205576.1	ADP91224.1
		ADP91225.1
		ADP91226.1
genomic	HQ205577.1	ADP91227.1
		ADP91228.1
		ADP91229.1
genomic	HQ205578.1	ADP91230.1
		ADP91231.1
		ADP91232.1
genomic	HQ205579.1	ADP91233.1
		ADP91234.1
		ADP91235.1
genomic	HQ205580.1	ADP91236.1
		ADP91237.1
		ADP91238.1
genomic	HQ205581.1	ADP91239.1
		ADP91240.1
		ADP91241.1
genomic	HQ205582.1	ADP91242.1
		ADP91243.1
		ADP91244.1
genomic	HQ205583.1	ADP91245.1
		ADP91246.1
		ADP91247.1
genomic	HQ205584.1	ADP91248.1
		ADP91249.1
		ADP91250.1
genomic	HQ205585.1	ADP91251.1
		ADP91252.1
		ADP91253.1
genomic	M69104.1	AAA88049.1
genomic	S68378.1	AAB20466.1
genomic	U80946.1	AAB64353.1
genomic	U80947.1	AAB64354.1
mRNA	AA737284.1	None
mRNA	AB307716.1	BAH02307.1
mRNA	AJ877166.1	CAI46893.1
mRNA	AJ877167.1	CAI46894.1
mRNA	AJ877168.1	CAI46895.1
mRNA	AJ877169.1	CAI46896.1
mRNA	AJ877170.1	CAI46897.1
mRNA	AJ877171.1	CAI46898.1
mRNA	AJ877172.1	CAI46899.1
mRNA	AJ888004.1	CAI59612.1
mRNA	AK223594.1	BAD97314.1
mRNA	AK302050.1	BAH13618.1
mRNA	AK314789.1	None
mRNA	AM183262.1	CAJ65924.1
mRNA	BC015610.2	AAH15610.1
mRNA	BF244382.1	None
mRNA	BF966114.1	None
mRNA	BX640610.1	CAE45716.1
mRNA	BX648553.1	None
mRNA	CA425706.1	None
mRNA	HQ450643.1	AED99114.1
mRNA	HQ450644.1	AED99115.1
mRNA	HQ692822.1	ADZ17333.1
mRNA	JN797823.1	AFA52009.1
mRNA	JN797824.1	AFA52010.1
mRNA	U01351.1	AAA16603.1
		AAA16604.1
mRNA	U25029.1	AAD14820.1
mRNA	X03225.1	CAA26976.1
mRNA	X03348.1	CAA27054.1
other-genetic	EU446477.1	ABZ92006.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P04150.1	GenPept	UniProtKB/Swiss-Prot:P04150
Q3MSN1	GenPept	UniProtKB/TrEMBL:Q3MSN1
Q3MSN4	GenPept	UniProtKB/TrEMBL:Q3MSN4