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Mau2 MAU2 sister chromatid cohesion factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 290668, updated on 3-Apr-2024

Summary

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Official Symbol
Mau2provided by RGD
Official Full Name
MAU2 sister chromatid cohesion factorprovided by RGD
Primary source
RGD:1308759
See related
Ensembl:ENSRNOG00000020526 AllianceGenome:RGD:1308759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308759
Summary
Predicted to enable double-stranded DNA binding activity and protein N-terminus binding activity. Predicted to be involved in cohesin loading and maintenance of mitotic sister chromatid cohesion. Predicted to be located in nuclear body. Predicted to be part of Scc2-Scc4 cohesin loading complex. Predicted to be active in chromatin. Orthologous to human MAU2 (MAU2 sister chromatid cohesion factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 168.4), Thymus (RPKM 135.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19417812..19448922)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19383847..19414996)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21132115..21163257)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene SURP and G patch domain containing 1 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene testis-specific serine kinase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22628566, Free PMC Article
  2. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. Seitan VC, et al. PLoS Biol, 2006 Jul. PMID 16802858, Free PMC Article
  3. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
  4. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Remeseiro S, et al. Biochim Biophys Acta, 2013 Dec. PMID 23920377, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cohesin loader activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SMC loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMC loading complex ISO
Inferred from Sequence Orthology
more info
  
part_of Scc2-Scc4 cohesin loading complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAU2 chromatid cohesion factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106077.4 → NP_001099547.2  MAU2 chromatid cohesion factor homolog isoform 1

    See identical proteins and their annotated locations for NP_001099547.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D3Z8G8
    Conserved Domains (2) summary
    sd00006
    Location:71 → 100
    TPR; TPR repeat [structural motif]
    pfam10345
    Location:30 → 576
    Cohesin_load; Cohesin loading factor

  2. NM_001277306.1 → NP_001264235.1  MAU2 chromatid cohesion factor homolog isoform 2

    See identical proteins and their annotated locations for NP_001264235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI045736, JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2JZP5, A6KA97
    Related
    ENSRNOP00000071129.1, ENSRNOT00000084243.2
    Conserved Domains (1) summary
    pfam10345
    Location:30 → 98
    Cohesin_load; Cohesin loading factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19417812..19448922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252877.5 → XP_006252939.1  MAU2 chromatid cohesion factor homolog isoform X1

    See identical proteins and their annotated locations for XP_006252939.1

    UniProtKB/TrEMBL
    A6KA95, D3Z8G8
    Conserved Domains (2) summary
    sd00006
    Location:71 → 100
    TPR; TPR repeat [structural motif]
    pfam10345
    Location:30 → 575
    Cohesin_load; Cohesin loading factor

  2. XM_063275189.1 → XP_063131259.1  MAU2 chromatid cohesion factor homolog isoform X2

RNA

  1. XR_005494570.2 RNA Sequence

  2. XR_005494572.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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