ATAD2 ATPase family, AAA domain containing 2 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ATAD2provided by HGNC
Official Full Name: ATPase family, AAA domain containing 2provided by HGNC
Primary source: HGNC:30123
Locus tag: L16
See related: Ensembl:ENSG00000156802; HPRD:10678; MIM:611941; Vega:OTTHUMG00000165090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANCCA; PRO2000; MGC5254; MGC29843; MGC131938; MGC142216; DKFZp667N1320
Summary: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 8q24.13

Sequence :: Chromosome: 8; NC_000008.10 (124332090..124408705, complement)

See ATAD2 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic aberrations and dysregulation in expression of p160/SRC coactivators and the ANCCA in breast cancer, prostate cancer, and other nonhormone-responsive cancers, are reviewed.
Title: The roles and action mechanisms of p160/SRC coactivators and the ANCCA coregulator in cancer.
Data show that that ANCCA is crucial for proliferation and survival of triple-negative/basal-like cancer cells and that it controls the expression of B-Myb and histone methyltransferase EZH2.
Title: ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.
Data report that ANCCA directly interacts with E2F1 to E2F3 in its complex with MLL and that its N terminus interacts with both the N and C termini of E2F1.
Title: Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.
Title: ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.
Findings suggest that ANCCA plays an important role in prostate cancer by mediating specific AR functions in cancer cell survival and proliferation.
Title: Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.
ANCCA interacts with AR, required for IGF1R,IRS-2,SGK1, survivin expression and proliferation and survival of prostate cancer cells. ANCCA itself is highly induced by androgen. Its overexpression is found in prostate cancers with high Gleason scores.
Title: Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.
ANCCA associates directly with ERalpha and ACTR. It is selectively recruited to a subset of ERalpha target genes (cyclin D1, c-myc, and E2F1) and is required for their estrogen-induced expression and breast cancer cell proliferation.
Title: ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:118827	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:118827	BioGRID:108202	E2F2	BioGRID	PubMed	Reconstituted Complex
BioGRID:118827	BioGRID:108203	E2F3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:118827	BioGRID:108206	E2F4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:118827	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:118827	BioGRID:113966	HIST2H4A	BioGRID	PubMed	Reconstituted Complex
BioGRID:118827	BioGRID:113895	HIST3H3	BioGRID	PubMed	Reconstituted Complex
BioGRID:118827	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:118827	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:118827	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:118827	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ATPase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: ATPase family AAA domain-containing protein 2

Names: ATPase family AAA domain-containing protein 2; AAA nuclear coregulator cancer-associated protein

NP_054828.2

EC 3.6.1.3

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014109.3 → NP_054828.2 ATPase family AAA domain-containing protein 2

Status: REVIEWED

Source sequence(s)

BC113656, BP314109, CA441499, CB159561

Consensus CDS

CCDS6343.1

UniProtKB/Swiss-Prot

Q6PL18

Related

ENSP00000287394, OTTHUMP00000228393, ENST00000287394, OTTHUMT00000381766

Conserved Domains (3) summary

COG0464
Location:445 – 934
Blast Score: 436

SpoVK; ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]

cd00009
Location:450 – 598
Blast Score: 266

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

cd05528
Location:987 – 1097
Blast Score: 464

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

124332090..124408705, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

119657854..119734371, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC021305.9 (15859..91805)	None
genomic	CH471060.1	EAW92033.1
		EAW92034.1
		EAW92035.1
		EAW92036.1
mRNA	AF118088.1	AAF22032.1
mRNA	AK097133.1	BAC04959.1
mRNA	AL833653.1	CAH56229.1
mRNA	AY598335.1	AAT06746.1
mRNA	BC007123.1	None
mRNA	BC010686.1	AAH10686.1
mRNA	BC019909.1	AAH19909.1
mRNA	BC112942.1	None
mRNA	BC113656.1	AAI13657.1
mRNA	BC143716.1	None
mRNA	BP314109.1	None
mRNA	CA441499.1	None
mRNA	CB159561.1	None
mRNA	CR749832.1	CAH18688.1
other-genetic	JF432508.1	ADZ15725.1