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    GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 [ Homo sapiens ]

    Gene ID: 2902, updated on 19-May-2012
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    Summary

    Official Symbol
    GRIN1provided by HGNC
    Official Full Name
    glutamate receptor, ionotropic, N-methyl D-aspartate 1provided by HGNC
    Primary source
    HGNC:4584
    Locus tag
    RP11-350O14.1
    See related
    Ensembl:ENSG00000176884; HPRD:15926; MIM:138249; Vega:OTTHUMG00000020976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR1; MRD8; GluN1; NMDA1; NMDAR1
    Summary
    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q34.3
    Sequence :
    Chromosome: 9; NC_000009.11 (140033609..140063214)
    See GRIN1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1B, member 1 Neighboring gene dipeptidyl-peptidase 7 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26 Neighboring gene transmembrane protein 210

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. NMDA receptors in dopaminergic neurons are crucial for habit learning. Wang LP, et al. Neuron, 2011 Dec 22. PMID 22196339.
    2. Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans. Mori F, et al. J Neurophysiol, 2011 Oct. PMID 21753020.
    3. Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test. McRoberts JA, et al. Neuroscience, 2011 Jan 13. PMID 20974228.
    4. A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms. Ding YX, et al. Dev Med Child Neurol, 2010 Nov. PMID 20722663.
    5. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Zhou X, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634195.

    See all (144) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Transgenic mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated functions such as locomotor activities.
      Title: NMDA receptors in dopaminergic neurons are crucial for habit learning.
    2. Homozygotes for the T allele in the rs4880213 GRIN1 SNP had reduced intracortical inhibition, as expected for enhanced glutamatergic excitation in these subjects.
      Title: Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans.
    3. NMDAR1 subunit expressed by primary afferent nerves of floxed mice plays an important role in the development of sensitized pain states.
      Title: Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test.
    4. Expression of NMDA receptors in lymphocytes is regulated by central nervous system, which controls the inflammation process.
      Title: NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo.
    5. The results of this study suggested that haplotypes of GRIN1 may influence responsiveness to ACTH.
      Title: A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms.
    6. Sp4 hypomorphic mice could therefore serve as a genetic model to investigate impaired NMDA functions resulting from loss-of-function mutations of human SP4 gene in schizophrenia and/or other psychiatric disorders.
      Title: Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders.
    7. Both tissue-type PA (tPA) and urokinase-type PA (uPA) bind to NMDA-R1 and reverse this effect, thereby enhancing acetylcholine-induced tracheal contractility.
      Title: Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.
    8. Functional NMDA receptors are expressed by breast cancer and are important agents for maintaining cell growth and viability.
      Title: Breast cancer expresses functional NMDA receptors.
    9. Polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan.
      Title: Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case-control study.
    10. The neuronal coexistence of glutamate and NMDAR1, observed in painful tendinosis but not in controls, suggests a regulatory role in intensified pain signalling.
      Title: Coexistence of up-regulated NMDA receptor 1 and glutamate on nerves, vessels and transformed tenocytes in tendinopathy.
    Submit: New GeneRIF Correction See all (53)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Mental retardation, autosomal dominant 8

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
    Tat tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed
    tat HIV-1 Tat upregulates expression of NMDA receptor 1 in mixed cultures of human neurons and astrocytes PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_015566.1 NP_001094.1 ACTN2    BIND  PubMed alpha-actinin-2 interacts with NR1A. This interaction was modeled on a demonstrated interaction between human alpha-actinin-2 and NR1A from an unspecified species. 
    NP_015566.1 NP_000824.1 GRIN2A    BIND  PubMed NR1a interacts with NR2A. 
    Q05586 P35609 ACTN2    HPRD  PubMed  
    Q05586 Q99996 AKAP9    HPRD  PubMed  
    Q05586 Calmodulin 1 CALM1    HPRD  PubMed  
    Q05586 Q9UQM7 CAMK2A    HPRD  PubMed  
    Q05586 P27824 CANX    HPRD  PubMed  
    Q05586 P19022 CDH2    HPRD  PubMed  
    Q05586 O14578 CIT    HPRD  PubMed  
    Q05586 Q00610 CLTC    HPRD  PubMed  
    Q05586 P35222 CTNNB1    HPRD  PubMed  
    Q05586 Q15700 DLG2    HPRD  PubMed  
    Q05586 Q92796 DLG3    HPRD  PubMed  
    Q05586 P78352 DLG4    HPRD  PubMed  
    Q05586 Q9Y2H0 DLGAP4    HPRD  PubMed  
    Q05586 Q05193 DNM1    HPRD  PubMed  
    Q05586 P21728 DRD1    HPRD  PubMed  
    Q05586 Q13115 DUSP4    HPRD  PubMed  
    Q05586 P29323 EPHB2    HPRD  PubMed  
    Q05586 P54760 EPHB4    HPRD  PubMed  
    Q05586 P35637 FUS    HPRD  PubMed  
    Q05586 Q05586 GRIN1    HPRD  PubMed  
    Q05586 Q12879 GRIN2A    HPRD  PubMed  
    Q05586 Q13224 GRIN2B    HPRD  PubMed  
    Q05586 O15399 GRIN2D    HPRD  PubMed  
    Q05586 Q8TCU5 GRIN3A    HPRD  PubMed  
    Q05586 Q00839 HNRNPU    HPRD  PubMed  
    Q05586 P01112 HRAS    HPRD  PubMed  
    Q05586 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    Q05586 Q16352 INA    HPRD  PubMed  
    Q05586 Q14114 LRP8    HPRD  PubMed  
    Q05586 P11137 MAP2    HPRD  PubMed  
    Q05586 P36507 MAP2K2    HPRD  PubMed  
    Q05586 P35579 MYH9    HPRD  PubMed  
    Q05586 Q8WY41 NANOS1    HPRD  PubMed  
    Q05586 P07196 NEFL    HPRD  PubMed  
    Q05586 P21359 NF1    HPRD  PubMed  
    Q05586 P00750 PLAT    HPRD  PubMed  
    Q05586 P19174 PLCG1    HPRD  PubMed  
    Q05586 P30153 PPP2R1A    HPRD  PubMed  
    Q05586 P63151 PPP2R2A    HPRD  PubMed  
    Q05586 P05771 PRKCB    HPRD  PubMed  
    Q05586 Q02156 PRKCE    HPRD  PubMed  
    Q05586 P05129 PRKCG    HPRD  PubMed  
    Q05586 P10114 RAP2A    HPRD  PubMed  
    Q05586 P51812 RPS6KA3    HPRD  PubMed  
    Q05586 Q02447 SP3    HPRD  PubMed  
    Q05586 Q13813 SPTAN1    HPRD  PubMed  
    Q05586 Q96PV0 SYNGAP1    HPRD  PubMed  
    Q05586 Q07157 TJP1    HPRD  PubMed  
    Q05586 Q13114 TRAF3    HPRD  PubMed  
    Q05586 Tubulin, alpha 4     HPRD  PubMed  
    BioGRID:109159 BioGRID:115648 CACNG2    BioGRID  PubMed Co-fractionation 
    BioGRID:109159 BioGRID:109160 GRIN2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109159 BioGRID:109161 GRIN2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109159 BioGRID:125508 GRIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109159 BioGRID:125509 GRIN3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109159 BioGRID:110632 ND2    BioGRID  PubMed Affinity Capture-Western 
    NP_003244.1 TIAM1    BIND  PubMed Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species. 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
    • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
      Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Nicotine addiction, organism-specific biosystem (from KEGG)
      Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Nicotine addiction, conserved biosystem (from KEGG)
      Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
      Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
      Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
      Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to N-methyl-D-aspartate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    extracellular-glutamate-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    glutamate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glycine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ionotropic glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of excitatory postsynaptic membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    N-methyl-D-aspartate selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    outer membrane-bounded periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synaptosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    glutamate [NMDA] receptor subunit zeta-1
    Names
    glutamate [NMDA] receptor subunit zeta-1
    NMD-R1
    glutamate [NMDA] receptor subunit zeta 1
    N-methyl-D-aspartate receptor subunit NR1
    N-methyl-D-aspartate receptor channel, subunit zeta-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011507.1 RefSeqGene

      Range
      5001..34606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000832.6 → NP_000823.4  glutamate [NMDA] receptor subunit zeta-1 isoform NR1-1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (NR1-1) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant NR1-3. The resulting protein (isoform NR1-1) is shorter and has a different C-terminus, compared to isoform NR1-3.
      Source sequence(s)
      AL929554, BU728516, L13266
      Consensus CDS
      CCDS43910.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360614, OTTHUMP00000022678, ENST00000371559, OTTHUMT00000055274
      Conserved Domains (6) summary
      cd00134
      Location:457 – 552
      Blast Score: 147
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      cd06379
      Location:8 – 383
      Blast Score: 1728
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835 – 863
      Blast Score: 136
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam00060
      Location:561 – 824
      Blast Score: 711
      Lig_chan; Ligand-gated ion channel
      cl15306
      Location:663 – 795
      Blast Score: 387
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      pfam01094
      Location:42 – 357
      Blast Score: 310
      ANF_receptor; Receptor family ligand binding region

    2. NM_001185090.1 → NP_001172019.1  glutamate [NMDA] receptor subunit zeta-1 isoform NR1-4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (NR1-4) contains an alternate coding segment and uses a different splice site in the 3' coding region, compared to variant NR1-3. The resulting protein (isoform NR1-4) is longer and has a distinct C-terminus when it is compared to isoform NR1-3. This variant has also been named isoform 4b or NMDAR1-4b.
      Source sequence(s)
      AB208999, AF015731, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55354.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      UniProtKB/TrEMBL
      Q5VSF5
      UniProtKB/TrEMBL
      Q9UPF8
      Related
      ENSP00000360608, OTTHUMP00000022677, ENST00000371553, OTTHUMT00000055273
      Conserved Domains (6) summary
      cd00134
      Location:478 – 573
      Blast Score: 146
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      cd06379
      Location:8 – 404
      Blast Score: 1727
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856 – 884
      Blast Score: 134
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam00060
      Location:582 – 845
      Blast Score: 716
      Lig_chan; Ligand-gated ion channel
      cl15306
      Location:684 – 816
      Blast Score: 386
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      pfam01094
      Location:42 – 378
      Blast Score: 294
      ANF_receptor; Receptor family ligand binding region

    3. NM_001185091.1 → NP_001172020.1  glutamate [NMDA] receptor subunit zeta-1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate coding segment, lacks a different alternate coding segment, and uses a different splice site in the 3' coding region, compared to variant NR1-3. The resulting protein (isoform 5) is shorter and has a distinct C-terminus when it is compared to isoform NR1-3. This variant has also been named isoform 3b or NMDAR1-3b.
      Source sequence(s)
      AB208999, AF015730, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55355.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      UniProtKB/TrEMBL
      Q5VSF4
      UniProtKB/TrEMBL
      Q9UPF9
      Related
      ENSP00000360615, OTTHUMP00000022679, ENST00000371560, OTTHUMT00000055275
      Conserved Domains (6) summary
      cd00134
      Location:478 – 573
      Blast Score: 146
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      cd06379
      Location:8 – 404
      Blast Score: 1726
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856 – 884
      Blast Score: 135
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam00060
      Location:582 – 845
      Blast Score: 713
      Lig_chan; Ligand-gated ion channel
      cl15306
      Location:684 – 816
      Blast Score: 386
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      pfam01094
      Location:42 – 378
      Blast Score: 293
      ANF_receptor; Receptor family ligand binding region

    4. NM_007327.3 → NP_015566.1  glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (NR1-3) represents the longest transcript and encodes protein isoform NR1-3.
      Source sequence(s)
      AL929554, BU728516, D13515
      Consensus CDS
      CCDS7031.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360616, OTTHUMP00000022673, ENST00000371561, OTTHUMT00000055267
      Conserved Domains (6) summary
      cd00134
      Location:457 – 552
      Blast Score: 147
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      cd06379
      Location:8 – 383
      Blast Score: 1734
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835 – 863
      Blast Score: 133
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam00060
      Location:561 – 824
      Blast Score: 716
      Lig_chan; Ligand-gated ion channel
      cl15306
      Location:663 – 795
      Blast Score: 387
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      pfam01094
      Location:42 – 357
      Blast Score: 313
      ANF_receptor; Receptor family ligand binding region

    5. NM_021569.3 → NP_067544.1  glutamate [NMDA] receptor subunit zeta-1 isoform NR1-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (NR1-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant NR1-3, resulting in a shorter protein (isoform NR1-2), compared to isoform NR1-3.
      Source sequence(s)
      AL929554, BU728516, D13515, L13267
      Consensus CDS
      CCDS7032.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360605, OTTHUMP00000022674, ENST00000371550, OTTHUMT00000055270
      Conserved Domains (6) summary
      cd00134
      Location:457 – 552
      Blast Score: 147
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      cd06379
      Location:8 – 383
      Blast Score: 1734
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835 – 863
      Blast Score: 134
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam00060
      Location:561 – 824
      Blast Score: 714
      Lig_chan; Ligand-gated ion channel
      cl15306
      Location:663 – 795
      Blast Score: 387
      PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
      pfam01094
      Location:42 – 357
      Blast Score: 312
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      140033609..140063214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      109493914..109523231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL929554.20 CAH72873.2
      CAH72874.2
      CAH72875.2
      CAH72876.2
      CAH72877.2
      CAH72878.2
      CAH72879.2
      CAM17671.1
    genomic CH471090.1 EAW88350.1
      EAW88351.1
      EAW88352.1
      EAW88353.1
      EAW88354.1
      EAW88355.1
      EAW88356.1
      EAW88357.1
      EAW88358.1
      EAW88359.1
      EAW88360.1
    mRNA AB208918.1 BAD92155.1
    mRNA AB208999.1 BAD92236.1
    mRNA AF015730.1 AAB67723.1
    mRNA AF015731.1 AAB67724.1
    mRNA BU728516.1 None
    mRNA D13515.1 BAA02732.1
    mRNA L05666.1 AAA21180.1
    mRNA L13266.1 AAB59360.1
    mRNA L13267.1 AAA36198.1
    mRNA L13268.1 AAB59361.1
    mRNA S57708.1 AAB25917.1
    mRNA U08106.1 AAA62111.1
    mRNA U08107.1 AAA62112.1
    other-genetic BC156097.1 AAI56098.1
    other-genetic BC156961.1 AAI56962.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05586.1 GenPept UniProtKB/Swiss-Prot:Q05586
    Q59GW0 GenPept UniProtKB/TrEMBL:Q59GW0
    Q59H41 GenPept UniProtKB/TrEMBL:Q59H41
    Q5VSF4 GenPept UniProtKB/TrEMBL:Q5VSF4
    Q5VSF5 GenPept UniProtKB/TrEMBL:Q5VSF5
    Q5VSF9 GenPept UniProtKB/TrEMBL:Q5VSF9
    Q9UPF8 GenPept UniProtKB/TrEMBL:Q9UPF8
    Q9UPF9 GenPept UniProtKB/TrEMBL:Q9UPF9
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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