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ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens (human) ]

Gene ID: 290, updated on 11-Sep-2014
Official Symbol
ANPEPprovided by HGNC
Official Full Name
alanyl (membrane) aminopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:500
See related
Ensembl:ENSG00000166825; HPRD:01055; MIM:151530; Vega:OTTHUMG00000149814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APN; CD13; LAP1; P150; PEPN; GP150
Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
See ANPEP in Epigenomics, MapViewer
Location:
15q25-q26
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (89784895..89814879, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90328126..90358119, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene mesoderm posterior basic helix-loop-helix transcription factor 2 Neighboring gene C15orf38-AP3S2 readthrough Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene microRNA 5094 Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiotensin maturation TAS
Traceable Author Statement
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
aminopeptidase N
Names
aminopeptidase N
AP-M
AP-N
hAPN
aminopeptidase M
alanyl aminopeptidase
microsomal aminopeptidase
myeloid plasma membrane glycoprotein CD13
NP_001141.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001150.2NP_001141.2  aminopeptidase N precursor

    See proteins identical to NP_001141.2

    Status: REVIEWED

    Source sequence(s)
    AB209918, AC079075, BC058928, BQ879097
    Consensus CDS
    CCDS10356.1
    UniProtKB/TrEMBL
    A0A024RC61
    UniProtKB/Swiss-Prot
    P15144
    UniProtKB/TrEMBL
    Q59E93
    Related
    ENSP00000300060, OTTHUMP00000194690, ENST00000300060, OTTHUMT00000313425
    Conserved Domains (3) summary
    cd09601
    Location:84550
    Blast Score: 1707
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    COG0308
    Location:86957
    Blast Score: 981
    PepN; Aminopeptidase N [Amino acid transport and metabolism]
    pfam11838
    Location:619942
    Blast Score: 377
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    89784895..89814879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254892.2XP_005254949.1  

    See proteins identical to XP_005254949.1

    UniProtKB/TrEMBL
    A0A024RC61
    UniProtKB/Swiss-Prot
    P15144
    Conserved Domains (3) summary
    cd09601
    Location:84550
    Blast Score: 1707
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    COG0308
    Location:86957
    Blast Score: 981
    PepN; Aminopeptidase N [Amino acid transport and metabolism]
    pfam11838
    Location:619942
    Blast Score: 377
    ERAP1_C; ERAP1-like C-terminal domain

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    66440812..66470613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    90169132..90199097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)