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Erlec1 endoplasmic reticulum lectin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289874, updated on 11-Apr-2024

Summary

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Official Symbol
Erlec1provided by RGD
Official Full Name
endoplasmic reticulum lectin 1provided by RGD
Primary source
RGD:1306508
See related
Ensembl:ENSRNOG00000007283 AllianceGenome:RGD:1306508
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306508
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of retrograde protein transport, ER to cytosol and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 301.5), Kidney (RPKM 291.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108856661..108894511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104655745..104693508, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115314890..115352871, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 4 Neighboring gene G protein-coupled receptor 75 Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene uncharacterized LOC134481883

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. Cruciat CM, et al. J Biol Chem, 2006 May 5. PMID 16531414
  2. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. Hosokawa N, et al. J Biol Chem, 2008 Jul 25. PMID 18502753, Free PMC Article
  3. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Christianson JC, et al. Nat Cell Biol, 2008 Mar. PMID 18264092, Free PMC Article
  4. Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. Groisman B, et al. J Biol Chem, 2011 Jan 14. PMID 21062743, Free PMC Article
  5. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106023.1 → NP_001099493.2  endoplasmic reticulum lectin 1 precursor

    See identical proteins and their annotated locations for NP_001099493.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473996
    UniProtKB/TrEMBL
    A6JQD3, D3ZF97
    Related
    ENSRNOP00000043115.4, ENSRNOT00000050321.5
    Conserved Domains (2) summary
    pfam07915
    Location:341 → 420
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:205 → 249
    PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    108856661..108894511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091779.2 → XP_038947707.1  endoplasmic reticulum lectin 1 isoform X2

    Conserved Domains (1) summary
    pfam07915
    Location:223 → 302
    PRKCSH; Glucosidase II beta subunit-like protein

  2. XM_063272989.1 → XP_063129059.1  endoplasmic reticulum lectin 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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