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    BZW2 basic leucine zipper and W2 domains 2 [ Homo sapiens (human) ]

    Gene ID: 28969, updated on 5-May-2013
    Official Symbol
    BZW2provided by HGNC
    Official Full Name
    basic leucine zipper and W2 domains 2provided by HGNC
    Primary source
    HGNC:18808
    Locus tag
    HSPC028
    See related
    Ensembl:ENSG00000136261; HPRD:16571; Vega:OTTHUMG00000130755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST017; HSPC028; MSTP017
    Location :
    7p21.1
    Sequence :
    Chromosome: 7; NC_000007.13 (16685759..16746148)
    See BZW2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene ataxin 2 related protein pseudogene Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene tetraspanin 13 Neighboring gene anterior gradient 2 homolog (Xenopus laevis)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Yu CC, et al. PLoS One, 2013. PMID 23383273.
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    3. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.
    4. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, et al. J Proteome Res, 2012 Feb 3. PMID 22053931.
    5. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. 5MP1 (BZW2) acts as a partial mimic and competitor of eIF5, interfering with the key steps by which eIF5 regulates eIF2 function.
      Title: Mechanisms of translational regulation by a human eIF5-mimic protein.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:118793 BioGRID:117383 ABHD14A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:115042 BZW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:116144 C11orf58    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:107273 CAPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:113387 CNBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:111472 CTSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:108040 DFFA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:109898 EIF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:118793 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:122295 GINS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:118793 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:111086 PAFAH1B2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:111221 PFAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:111528 PPP5C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:114513 PSTPIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118793 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    basic leucine zipper and W2 domain-containing protein 2
    Names
    basic leucine zipper and W2 domain-containing protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159767.1 → NP_001153239.1  basic leucine zipper and W2 domain-containing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF083246, BC051898, BC107757
      Consensus CDS
      CCDS5362.1
      UniProtKB/Swiss-Prot
      Q9Y6E2
      Related
      ENSP00000397249, ENST00000433922
      Conserved Domains (1) summary
      cd11560
      Location:218 – 408
      Blast Score: 790
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    2. NM_014038.2 → NP_054757.1  basic leucine zipper and W2 domain-containing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF083246, BC009597, BC051898
      Consensus CDS
      CCDS5362.1
      UniProtKB/Swiss-Prot
      Q9Y6E2
      Related
      ENSP00000258761, OTTHUMP00000161321, ENST00000258761, OTTHUMT00000253256
      Conserved Domains (1) summary
      cd11560
      Location:218 – 408
      Blast Score: 790
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RNA

    1. NR_027624.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF083246, BC051898

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p10 Primary Assembly

      Range
      16685759..16746148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      16572228..16633301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      16738882..16799268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018918.1 Alternate CHM1_1.0

      Range
      16659733..16720115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AACC02000008.1 (1380076..1440462) None
    genomic ABBA01056632.1 (28167..49420) None
    genomic ABBA01056633.1 None
    genomic ABBA01056634.1 None
    genomic AC073201.6 AAS07544.1
    genomic AC073333.5 None
    genomic AMYH01017092.1 (318448..378830) None
    genomic CH236948.1 EAL24285.1
    genomic CH471073.1 EAW93675.1
      EAW93676.1
      EAW93677.1
      EAW93678.1
      EAW93679.1
    mRNA AF083246.1 AAD39844.1
    mRNA AF110323.1 AAG39278.1
    mRNA AK001218.1 BAA91562.1
    mRNA AK001260.1 BAG50880.1
    mRNA AK027837.1 BAB55401.1
    mRNA AK297496.1 BAH12594.1
    mRNA AK300655.1 BAH13321.1
    mRNA BC001570.1 None
    mRNA BC003056.1 AAH03056.1
    mRNA BC008453.1 AAH08453.1
    mRNA BC009597.1 AAH09597.1
    mRNA BC017794.1 AAH17794.1
    mRNA BC051898.1 None
    mRNA BC107757.1 AAI07758.1
    other-genetic DQ892496.2 ABM83422.1
    other-genetic DQ895708.2 ABM86634.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6E2.1 GenPept UniProtKB/Swiss-Prot:Q9Y6E2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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