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SLC27A6 solute carrier family 27 member 6 [ Homo sapiens (human) ]

Gene ID: 28965, updated on 12-May-2016
Official Symbol
SLC27A6provided by HGNC
Official Full Name
solute carrier family 27 member 6provided by HGNC
Primary source
HGNC:HGNC:11000
See related
Ensembl:ENSG00000113396 HPRD:09173; MIM:604196; Vega:OTTHUMG00000128991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FATP6; ACSVL2; FACVL2; VLCS-H1
Summary
This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (128965475..129033642)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (128300951..128369335)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene fibrillin 2 Neighboring gene uncharacterized LOC105379168 Neighboring gene uncharacterized LOC105379167 Neighboring gene uncharacterized LOC102723638 Neighboring gene microRNA 4633 Neighboring gene isochorismatase domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of fatty acids, organism-specific biosystem (from REACTOME)
    Transport of fatty acids, organism-specific biosystemLong chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production o...
  • Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem (from REACTOME)
    Transport of vitamins, nucleosides, and related molecules, organism-specific biosystemThis pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp779M0564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty acid transporter activity TAS
Traceable Author Statement
more info
 
long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transport TAS
Traceable Author Statement
more info
 
very long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
long-chain fatty acid transport protein 6
Names
acyl-CoA synthetase very long chain family, member 2
fatty-acid-Coenzyme A ligase, very long-chain 2
solute carrier family 27 (fatty acid transporter), member 6
very long-chain acyl-CoA synthetase homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017372.2NP_001017372.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_001017372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AL833117, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q9Y2P4
    Related
    ENSP00000262462, OTTHUMP00000159240, ENST00000262462, OTTHUMT00000250980
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  2. NM_001317984.1NP_001304913.1  long-chain fatty acid transport protein 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AK313456, BX537383
    UniProtKB/Swiss-Prot
    Q9Y2P4
    UniProtKB/TrEMBL
    B2R8P6
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  3. NM_014031.4NP_054750.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_054750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AA614135, AC004636, AF064254, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q9Y2P4
    Related
    ENSP00000378684, OTTHUMP00000223224, ENST00000395266, OTTHUMT00000371831
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    128965475..129033642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271970.3XP_005272027.1  

    See identical proteins and their annotated locations for XP_005272027.1

    UniProtKB/Swiss-Prot
    Q9Y2P4
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  2. XM_005271968.3XP_005272025.1  

    See identical proteins and their annotated locations for XP_005272025.1

    UniProtKB/Swiss-Prot
    Q9Y2P4
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  3. XM_005271969.3XP_005272026.1  

    See identical proteins and their annotated locations for XP_005272026.1

    UniProtKB/Swiss-Prot
    Q9Y2P4
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  4. XM_005271967.1XP_005272024.1  

    Related
    ENSP00000421024, OTTHUMP00000223225, ENST00000506176, OTTHUMT00000371832
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  5. XM_011543348.1XP_011541650.1  

    Conserved Domains (1) summary
    cl17068
    Location:13303
    AFD_class_I; Adenylate forming domain, Class I superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    127734035..127802014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)