REM1 RAS (RAD and GEM)-like GTP-binding 1 [Homo sapiens] - Gene

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Summary

Official Symbol: REM1provided by HGNC
Official Full Name: RAS (RAD and GEM)-like GTP-binding 1provided by HGNC
Primary source: HGNC:15922
See related: Ensembl:ENSG00000088320; HPRD:15237; MIM:610388; Vega:OTTHUMG00000032168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GES; REM; GD:REM; MGC48669
Summary: The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q11.21

Sequence :: Chromosome: 20; NC_000020.10 (30063105..30072708)

See REM1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a role for the Rem C terminus in plasma membrane localization through association with phosphatidylinositol lipids.
Title: Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.
We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition.
Title: L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O75628	Q02641	CACNB1	HPRD	PubMed
O75628	Q08289	CACNB2	HPRD	PubMed
O75628	O00305	CACNB4	HPRD	PubMed
O75628	O75628	REM1	HPRD	PubMed
O75628	P62258	YWHAE	HPRD	PubMed
O75628	Q04917	YWHAH	HPRD	PubMed
O75628	P27348	YWHAQ	HPRD	PubMed
O75628	P63104	YWHAZ	HPRD	PubMed
BioGRID:118781	BioGRID:113363	YWHAE	BioGRID	PubMed	Far Western
BioGRID:118781	BioGRID:113365	YWHAH	BioGRID	PubMed	Far Western
BioGRID:118781	BioGRID:116168	YWHAQ	BioGRID	PubMed	Far Western
BioGRID:118781	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: GTP-binding protein REM 1

Names: GTP-binding protein REM 1; GTPase GES; rad and Gem-like GTP-binding protein 1; GTPase-regulating endothelial cell sprouting

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014012.4 → NP_054731.2 GTP-binding protein REM 1

Status: REVIEWED

Source sequence(s)

AF152863, BC039813

Consensus CDS

CCDS13181.1

UniProtKB/Swiss-Prot

O75628

Related

ENSP00000201979, OTTHUMP00000030521, ENST00000201979, OTTHUMT00000078508

Conserved Domains (1) summary

cd04148
Location:81 – 250
Blast Score: 734

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

30063105..30072708

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

26851246..26860903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121751.12	CAB90274.1
genomic	CH471077.2	EAW76439.1
		EAW76440.1
		EAW76441.1
		EAW76442.1
mRNA	AF084465.1	AAC33132.1
mRNA	AF152863.1	AAF74212.1
mRNA	AK313060.1	BAG35890.1
mRNA	BC039813.1	AAH39813.1
mRNA	BT020078.1	AAV38881.1
mRNA	BT020079.1	AAV38882.1