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Cdk18 cyclin-dependent kinase 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289019, updated on 11-Apr-2024

Summary

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Official Symbol
Cdk18provided by RGD
Official Full Name
cyclin-dependent kinase 18provided by RGD
Primary source
RGD:1309523
See related
Ensembl:ENSRNOG00000008137 AllianceGenome:RGD:1309523
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pctk3; PCTAIRE3
Summary
Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK18 (cyclin dependent kinase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 53.4), Liver (RPKM 22.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46107763..46140705, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43555597..43582210, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48893525..48926673, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene uncharacterized LOC134481495 Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1 Neighboring gene kelch domain containing 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Hirose T, et al. Eur J Biochem, 1997 Oct 15. PMID 9370357
  2. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 18
Names
PCTAIRE protein kinase 3
PCTAIRE-motif protein kinase 3
cell division protein kinase 18
serine/threonine-protein kinase PCTAIRE-3
NP_001093976.1
XP_006249813.1
XP_063128137.1
XP_063128138.1
XP_063128140.1
XP_063128141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100506.1 → NP_001093976.1  cyclin-dependent kinase 18

    See identical proteins and their annotated locations for NP_001093976.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082045
    UniProtKB/Swiss-Prot
    O35832
    UniProtKB/TrEMBL
    A0A0H2UHG4, Q641Z0
    Related
    ENSRNOP00000095753.1, ENSRNOT00000114199.1
    Conserved Domains (1) summary
    cl21453
    Location:115 → 402
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    46107763..46140705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272068.1 → XP_063128138.1  cyclin-dependent kinase 18 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A946

  2. XM_063272067.1 → XP_063128137.1  cyclin-dependent kinase 18 isoform X1

  3. XM_063272071.1 → XP_063128141.1  cyclin-dependent kinase 18 isoform X3

    UniProtKB/Swiss-Prot
    O35832
    UniProtKB/TrEMBL
    Q641Z0

  4. XM_006249751.5 → XP_006249813.1  cyclin-dependent kinase 18 isoform X3

    See identical proteins and their annotated locations for XP_006249813.1

    UniProtKB/Swiss-Prot
    O35832
    UniProtKB/TrEMBL
    A0A0H2UHG4, Q641Z0
    Conserved Domains (1) summary
    cl21453
    Location:115 → 402
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063272070.1 → XP_063128140.1  cyclin-dependent kinase 18 isoform X3

    UniProtKB/Swiss-Prot
    O35832
    UniProtKB/TrEMBL
    Q641Z0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35832.1 GenPept UniProtKB/Swiss-Prot:O35832

Gene LinkOut

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