GRB14 growth factor receptor-bound protein 14 [Homo sapiens] - Gene

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Summary

Official Symbol: GRB14provided by HGNC
Official Full Name: growth factor receptor-bound protein 14provided by HGNC
Primary source: HGNC:4565
See related: Ensembl:ENSG00000115290; HPRD:03313; MIM:601524; Vega:OTTHUMG00000132135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 2q22-q24

Sequence :: Chromosome: 2; NC_000002.11 (165349323..165478360, complement)

See GRB14 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Grb14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma
Title: Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Grb14 regulates insulin action at two levels, through insulin receptors binding and by interfering with downstream pathways.
Title: Molecular determinants of Grb14-mediated inhibition of insulin signaling.
Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14.
Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Grb14 may regulate signalling through the insulin receptor by controlling its tyrosine dephosphorylation in a site-specific manner.
Title: Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
serves as an adaptor protein to recruit 3-phosphoinositede-dependent kinase-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal
Title: The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.
GRB14 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may improve insulin signaling, with weight loss.
Title: GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.
regulation of Grb14 expression levels in response to hormonal stimuli, and are consistent with its role as a repressor of insulin signaling where it is induced as a negative feedback mechanism.
Title: Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association of lipid-lowering response to statins in combined study populations.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14449	P00533	EGFR	HPRD	PubMed
Q14449	P11362	FGFR1	HPRD	PubMed
Q14449	P06213	INSR	HPRD	PubMed
Q14449	P35568	IRS1	HPRD	PubMed
Q14449	Q99558	MAP3K14	HPRD	PubMed
Q14449	P16234	PDGFRA	HPRD	PubMed
Q14449	P09619	PDGFRB	HPRD	PubMed
Q14449	Q05513	PRKCZ	HPRD	PubMed
Q14449	Q13501	SQSTM1	HPRD	PubMed
Q14449	Q02763	TEK	HPRD	PubMed
Q14449	Q9H2K2	TNKS2	HPRD	PubMed
BioGRID:109145	BioGRID:107983	DAPK3	BioGRID	PubMed	Reconstituted Complex
BioGRID:109145	BioGRID:108276	EGFR	BioGRID	PubMed	Reconstituted Complex
BioGRID:109145	BioGRID:108551	FGFR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109145	BioGRID:116053	FTCD	BioGRID	PubMed	Co-fractionation
BioGRID:109145	BioGRID:109854	INSR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109145	BioGRID:111185	PDGFRB	BioGRID	PubMed	Reconstituted Complex
BioGRID:109145	BioGRID:111576	PRKCZ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109145	BioGRID:123257	TNKS2	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
SH3/SH2 adaptor activity	IEA Inferred from Electronic Annotation more info
phosphoprotein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
blood coagulation	TAS Traceable Author Statement more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
leukocyte migration	TAS Traceable Author Statement more info
negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi membrane	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IEA Inferred from Electronic Annotation more info
microsome	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: growth factor receptor-bound protein 14

Names: growth factor receptor-bound protein 14; GRB14 adapter protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004490.2 → NP_004481.2 growth factor receptor-bound protein 14

Status: REVIEWED

Source sequence(s)

AC107075, BC053559, L76687

Consensus CDS

CCDS2222.1

UniProtKB/Swiss-Prot

Q14449

Related

ENSP00000263915, OTTHUMP00000163009, ENST00000263915, OTTHUMT00000255180

Conserved Domains (4) summary

pfam08947
Location:373 – 417
Blast Score: 236

BPS; BPS (Between PH and SH2)

cd01787
Location:106 – 190
Blast Score: 394

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10414
Location:433 – 540
Blast Score: 606

SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins

cl00273
Location:236 – 347
Blast Score: 259

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

165349323..165478360, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

157231772..157360824, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC107075.4	AAY14768.1
genomic	AC110086.3	AAY24176.1
genomic	CH471058.2	EAX11342.1
		EAX11343.1
mRNA	AK074599.1	None
mRNA	AK301961.1	BAH13595.1
mRNA	AK302129.1	BAH13632.1
mRNA	AK307744.1	None
mRNA	AK309590.1	None
mRNA	AK313153.1	BAG35971.1
mRNA	BC053559.1	AAH53559.1
mRNA	L76687.1	AAC15861.1
other-genetic	EU832411.1	ACE86896.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q14449.2	GenPept	UniProtKB/Swiss-Prot:Q14449
Q53QM9	GenPept	UniProtKB/TrEMBL:Q53QM9
Q53QQ0	GenPept	UniProtKB/TrEMBL:Q53QQ0