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    GRB7 growth factor receptor-bound protein 7 [ Homo sapiens ]

    Gene ID: 2886, updated on 5-Feb-2012
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    Summary

    Official Symbol
    GRB7provided by HGNC
    Official Full Name
    growth factor receptor-bound protein 7provided by HGNC
    Primary source
    HGNC:4567
    See related
    Ensembl:ENSG00000141738; HPRD:03311; MIM:601522; Vega:OTTHUMG00000133253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
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    Genomic context

    Location :
    17q12
    Sequence :
    Chromosome: 17; NC_000017.10 (37894162..37903538)
    See GRB7 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Neighboring gene microRNA 4728 Neighboring gene migration and invasion enhancer 1 Neighboring gene IKAROS family zinc finger 3 (Aiolos) Neighboring gene keratin 8 pseudogene 34 Neighboring gene ribosomal protein L39 pseudogene 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide. Yap MY, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Dec 1. PMID 21139214.
    3. Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation. Siamakpour-Reihani S, et al. J Mol Recognit, 2011 Mar-Apr. PMID 20665473.
    4. GRB7 protein over-expression and clinical outcome in breast cancer. Ramsey B, et al. Breast Cancer Res Treat, 2011 Jun. PMID 20635137.
    5. EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. Chu PY, et al. J Biol Chem, 2010 Sep 17. PMID 20622016.

    See all (58) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. GRB7 protein over-expression is an independent adverse prognostic factor in human breast cancer
      Title: GRB7 protein over-expression and clinical outcome in breast cancer.
    2. Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated.
      Title: Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.
    3. X-ray diffraction data were collected from crystals to 2.4A resolution for G7-18NATE in complex with its Grb7 SH2 domain.
      Title: Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide.
    4. proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation
      Title: The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation.
    5. Data show that Grb7 removal by RNA-interference reduces breast cancer cell viability.
      Title: Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.
    6. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
      Title: EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
    7. Studies implicate that the overexpressed GRB7 and GRB7v are associated with high-grade tumors and exert distinct tumorigenic functions through regulating different signaling pathways in ovarian cancer cells.
      Title: Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis.
    8. High Grb7 is associated with breast cancer.
      Title: Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.
    9. Formation of focal adhesion kinase *Grb7 complexes and Grb7 phosphorylation by FAK in an integrin-dependent manner were essential for cell migration, proliferation and anchorage-independent growth in A431 epidermal carcinoma cells.
      Title: Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.
    10. Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14.
      Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
    Submit: New GeneRIF Correction See all (26)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005301.1 NP_008819.1 CALM1    BIND  PubMed Grb7 interacts with CaM. This interaction was modeled on a demonstrated interaction between human Grb7 and CaM from rat and an unspecified species. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PA. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(3,5)P2. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(3,4,5)P3. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(4,5)P2. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(3)P. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(5)P. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(3,4)P2. 
    NP_005301.1     BIND  PubMed Grb7 interacts with PI(4)P. 
    Q14451 Calmodulin 1 CALM1    HPRD  PubMed  
    Q14451 Q03135 CAV1    HPRD  PubMed  
    Q14451 P00533 EGFR    HPRD  PubMed  
    Q14451 P04626 ERBB2    HPRD  PubMed  
    Q14451 P21860 ERBB3    HPRD  PubMed  
    Q14451 P62993 GRB2    HPRD  PubMed  
    Q14451 P06213 INSR    HPRD  PubMed  
    Q14451 P10721 KIT    HPRD  PubMed  
    Q14451 Chromosome 6 open reading frame 21 LY6G6F    HPRD  PubMed  
    Q14451 Q99558 MAP3K14    HPRD  PubMed  
    Q14451 P09619 PDGFRB    HPRD  PubMed  
    Q14451 Q05397 PTK2    HPRD  PubMed  
    Q14451 P07949 RET    HPRD  PubMed  
    Q14451 Q92730 RND1    HPRD  PubMed  
    Q14451 P29353 SHC1    HPRD  PubMed  
    Q14451 Q02763 TEK    HPRD  PubMed  
    BioGRID:109143 BioGRID:106523 A1BG    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:125550 AGAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:106994 ATP5B    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:107252 CALM1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex 
    BioGRID:109143 BioGRID:114763 CPNE6    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:124527 DOCK7    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:108118 DYNC1I1    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:108361 EPHB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109143 BioGRID:108376 ERBB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109143 BioGRID:108377 ERBB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109143 BioGRID:108535 FGB    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:123221 FLAD1    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:109045 GNB2    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:109282 HADHB    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:109854 INSR    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109143 BioGRID:110015 KIT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109143 BioGRID:129225 LY6G6F    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109143 BioGRID:115104 MLL4    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:110573 MSH2    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109143 BioGRID:111188 PDHB    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:119734 PHAX    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:111332 PKM2    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109143 BioGRID:111911 RET    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:109143 BioGRID:118113 RND1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109143 BioGRID:112101 RPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109143 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:112969 TMSB4X    BioGRID  PubMed Two-hybrid 
    BioGRID:109143 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
      Angiopoietin receptor Tie2-mediated signaling
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • GRB7 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      GRB7 events in ERBB2 signaling, organism-specific biosystemHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of thi...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
      Signaling events regulated by Ret tyrosine kinase
    • Tie2 Signaling, organism-specific biosystem (from REACTOME)
      Tie2 Signaling, organism-specific biosystemThe Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belong...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    growth factor receptor-bound protein 7
    Names
    growth factor receptor-bound protein 7
    B47
    GRB7 adapter protein
    epidermal growth factor receptor GRB-7
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029932.1 RefSeqGene

      Range
      5001..14377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001030002.2 → NP_001025173.1  growth factor receptor-bound protein 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AU124875, BC006535
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      Q14451
      Related
      ENSP00000377761, OTTHUMP00000164350, ENST00000394211, OTTHUMT00000257025
      Conserved Domains (4) summary
      pfam08947
      Location:365 – 413
      Blast Score: 237
      BPS; BPS (Between PH and SH2)
      cd01787
      Location:100 – 184
      Blast Score: 378
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425 – 532
      Blast Score: 581
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cl00273
      Location:231 – 343
      Blast Score: 216
      PH-like; Pleckstrin homology-like domain

    2. NM_001242442.1 → NP_001229371.1  growth factor receptor-bound protein 7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (b).
      Source sequence(s)
      AC079199, AK125544, BC006535
      Consensus CDS
      CCDS56028.1
      UniProtKB/Swiss-Prot
      Q14451
      Related
      ENSP00000403459, ENST00000445327
      Conserved Domains (4) summary
      pfam08947
      Location:388 – 436
      Blast Score: 236
      BPS; BPS (Between PH and SH2)
      cd01787
      Location:123 – 207
      Blast Score: 380
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:448 – 555
      Blast Score: 582
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cl00273
      Location:254 – 366
      Blast Score: 215
      PH-like; Pleckstrin homology-like domain

    3. NM_001242443.1 → NP_001229372.1  growth factor receptor-bound protein 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK290115, BC006535
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      Q14451
      Conserved Domains (4) summary
      pfam08947
      Location:365 – 413
      Blast Score: 237
      BPS; BPS (Between PH and SH2)
      cd01787
      Location:100 – 184
      Blast Score: 378
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425 – 532
      Blast Score: 581
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cl00273
      Location:231 – 343
      Blast Score: 216
      PH-like; Pleckstrin homology-like domain

    4. NM_005310.3 → NP_005301.2  growth factor receptor-bound protein 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK222870, BC006535, DC384178
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      Q14451
      Related
      ENSP00000310771, OTTHUMP00000164349, ENST00000309156, OTTHUMT00000257024
      Conserved Domains (4) summary
      pfam08947
      Location:365 – 413
      Blast Score: 237
      BPS; BPS (Between PH and SH2)
      cd01787
      Location:100 – 184
      Blast Score: 378
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425 – 532
      Blast Score: 581
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cl00273
      Location:231 – 343
      Blast Score: 216
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      37894162..37903538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      33687978..33697340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079199.9 (82391..91742) None
    genomic AF274875.1 AAG25938.1
    genomic CH471152.1 EAW60600.1
      EAW60601.1
    mRNA AB008789.1 BAA29059.1
    mRNA AB008790.1 BAA29060.1
    mRNA AK027729.1 BAG51372.1
    mRNA AK125544.1 BAG54211.1
    mRNA AK222849.1 BAD96569.1
    mRNA AK222870.1 BAD96590.1
    mRNA AK290115.1 BAF82804.1
    mRNA AK294620.1 BAG57803.1
    mRNA AK314368.1 BAG36998.1
    mRNA AU124875.1 None
    mRNA BC006535.2 AAH06535.1
    mRNA BE247550.1 None
    mRNA BT006686.1 AAP35332.1
    mRNA D43772.1 BAA07827.1
    mRNA D87513.1 BAA13412.1
    mRNA DC384178.1 None
    other-genetic DQ893861.2 ABM84787.1
    other-genetic EU176171.1 ABW03622.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q14451.2 GenPept UniProtKB/Swiss-Prot:Q14451
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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