GPX7 glutathione peroxidase 7 [Homo sapiens] - Gene

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Summary

Official Symbol: GPX7provided by HGNC
Official Full Name: glutathione peroxidase 7provided by HGNC
Primary source: HGNC:4559
Locus tag: UNQ469/PRO828
See related: Ensembl:ENSG00000116157; HPRD:13606; Vega:OTTHUMG00000008322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPX6; CL683; GPx-7; NPGPx; GSHPx-7; FLJ14777

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Genomic context

Location :: 1p32

Sequence :: Chromosome: 1; NC_000001.10 (53068043..53074723)

See GPX7 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPx7 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase
Title: Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism
Title: Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes	PubMed
	tat	Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96SL4	O43765	SGTA	HPRD	PubMed
Q96SL4	Q9NRR5	UBQLN4	HPRD	PubMed
BioGRID:109139	BioGRID:112347	SGTA	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: glutathione peroxidase 7

Names: glutathione peroxidase 7; glutathione peroxidase 6; non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase

NP_056511.2

EC 1.11.1.9

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015696.4 → NP_056511.2 glutathione peroxidase 7 precursor

Status: VALIDATED

Source sequence(s)

AK027683, BI550170, BU627166

Consensus CDS

CCDS569.1

UniProtKB/Swiss-Prot

Q96SL4

Related

ENSP00000354677, OTTHUMP00000010021, ENST00000361314, OTTHUMT00000022913

Conserved Domains (1) summary

cd00340
Location:24 – 172
Blast Score: 546

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

53068043..53074723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

51188252..51190619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL356976.30	CAI22476.1
genomic	CH471059.2	EAX06777.1
genomic	DQ096732.1	AAY88741.1
mRNA	AF091092.1	AAC72961.1
mRNA	AF320068.2	AAN76501.1
mRNA	AK027683.1	BAB55294.1
mRNA	AY358402.1	AAQ88768.1
mRNA	BC032788.1	AAH32788.1
mRNA	BI550170.1	None
mRNA	BU627166.1	None
other-genetic	DQ894018.2	ABM84944.1