Ephb3 Eph receptor B3 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Ephb3provided by RGD
Official Full Name: Eph receptor B3provided by RGD
Primary source: RGD:1305602
See related: Ensembl:ENSRNOG00000031801
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus

Genomic context

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Location :: 11q23

Sequence :: Chromosome: 11; NC_005110.3 (86602390..86621102, complement)

See Ephb3 in MapViewer

Chromosome 11 - NC_005110.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

EphB3 may play a role in the maintenance of mature neuronal connections or re-arrangement of synaptic connections during late stages of development.
Title: EphB3 receptor and ligand expression in the adult rat brain.
EphB3 is upregulated after spinal cord injury; this may contribute to an environment in the spinal cord that is inhibitory to axonal regeneration.
Title: Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

General gene information

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Markers

Ephb3 (e-PCR), detects polymorphism
- UniSTS:526857

RH70256 (e-PCR)
- UniSTS:9039

Ephb3 (e-PCR), detects polymorphism
- UniSTS:527340

Z49086 (e-PCR)
- UniSTS:125935

Ephb3 (e-PCR), detects polymorphism
- UniSTS:266993

Homology

Homologs of the Ephb3 gene: The Ephb3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
axon guidance receptor activity	IEA Inferred from Electronic Annotation more info
axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
ephrin receptor activity	IEA Inferred from Electronic Annotation more info
ephrin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
angiogenesis	ISO Inferred from Sequence Orthology more info
axon guidance	ISO Inferred from Sequence Orthology more info
axonal fasciculation	IEA Inferred from Electronic Annotation more info
axonal fasciculation	ISO Inferred from Sequence Orthology more info
cell migration	IEA Inferred from Electronic Annotation more info
cell migration	ISO Inferred from Sequence Orthology more info
central nervous system projection neuron axonogenesis	IEA Inferred from Electronic Annotation more info
central nervous system projection neuron axonogenesis	ISO Inferred from Sequence Orthology more info
corpus callosum development	IEA Inferred from Electronic Annotation more info
corpus callosum development	ISO Inferred from Sequence Orthology more info
dendritic spine development	ISO Inferred from Sequence Orthology more info
dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
palate development	IEA Inferred from Electronic Annotation more info
palate development	ISO Inferred from Sequence Orthology more info
positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
regulation of Cdc42 GTPase activity	IEA Inferred from Electronic Annotation more info
regulation of Cdc42 GTPase activity	ISO Inferred from Sequence Orthology more info
regulation of Rac GTPase activity	IEA Inferred from Electronic Annotation more info
regulation of Rac GTPase activity	ISO Inferred from Sequence Orthology more info
regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
retinal ganglion cell axon guidance	IEA Inferred from Electronic Annotation more info
retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
signal transduction	ISO Inferred from Sequence Orthology more info
substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
thymus development	IEA Inferred from Electronic Annotation more info
thymus development	ISO Inferred from Sequence Orthology more info
urogenital system development	IEA Inferred from Electronic Annotation more info
urogenital system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
integral to plasma membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-B receptor 3

Names: ephrin type-B receptor 3; EPH-like tyrosine kinase-2

NP_001099338.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105868.1 → NP_001099338.1 ephrin type-B receptor 3 precursor

Status: PROVISIONAL

Source sequence(s)

CH473999

UniProtKB/TrEMBL

D3ZH39

Related

ENSRNOP00000039489, ENSRNOT00000044896

Conserved Domains (7) summary

cd00063
Location:468 – 537
Blast Score: 141

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07699
Location:276 – 308
Blast Score: 105

GCC2_GCC3; GCC2 and GCC3

cd05065
Location:623 – 891
Blast Score: 1566

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd10478
Location:31 – 203
Blast Score: 959

EphR_LBD_B3; Ligand Binding Domain of Ephrin type-B Receptor 3

pfam07647
Location:917 – 982
Blast Score: 232

SAM_2; SAM domain (Sterile alpha motif)

pfam07714
Location:628 – 887
Blast Score: 1050

Pkinase_Tyr; Protein tyrosine kinase

cl15755
Location:917 – 985
Blast Score: 369

SAM_superfamily; SAM (Sterile alpha motif )