Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    GPX3 glutathione peroxidase 3 (plasma) [ Homo sapiens (human) ]

    Gene ID: 2878, updated on 15-Jun-2013
    Official Symbol
    GPX3provided by HGNC
    Official Full Name
    glutathione peroxidase 3 (plasma)provided by HGNC
    Primary source
    HGNC:4555
    See related
    Ensembl:ENSG00000211445; HPRD:11750; MIM:138321; Vega:OTTHUMG00000163693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPx-P; GSHPx-3; GSHPx-P
    Summary
    This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
    Location :
    5q23
    Sequence :
    Chromosome: 5; NC_000005.9 (150399999..150408554)
    See GPX3 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene zinc finger protein 300 pseudogene 1 Neighboring gene zinc finger protein 35 pseudogene Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene annexin A6

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. Peng DF, et al. PLoS One, 2012. PMID 23071548.
    2. Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico. Baez-Duarte BG, et al. Arch Med Res, 2012 Oct. PMID 22981671.
    3. A role for GPx3 in activity of normal and leukemia stem cells. Herault O, et al. J Exp Med, 2012 May 7. PMID 22508837.
    4. p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. Wang H, et al. J Biol Chem, 2012 May 11. PMID 22461624.
    5. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Hao Y, et al. Chin Med J (Engl), 2011 Jul. PMID 21933611.

    See all (60) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. determination of GPx3 levels in overweight and obese subjects from central Mexico
      Title: Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico.
    2. dysfunction of GPX3 in gastric cancer is mediated by genetic and epigenetic alterations, suggesting impairment of mechanisms that regulate ROS and its possible involvement in gastric tumorigenesis and metastasis
      Title: Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas.
    3. GPX3 overexpression was found in clear cell type ovarian adenocarcinoma compared with normal ovary and 3 other subtypes of epithelial ovarian cancer at mRNA level.
      Title: Immunohistochemical evidence for the over-expression of Glutathione peroxidase 3 in clear cell type ovarian adenocarcinoma.
    4. In human primary acute myeloid leukemia samples, GPX3 expression level directly correlated with adverse prognostic outcome and positively correlated with the frequency of leukemia stem cells (LSCs).
      Title: A role for GPx3 in activity of normal and leukemia stem cells.
    5. a novel signaling pathway of GPx3-PIG3 in the regulation of cell death in prostate cancer.
      Title: p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3.
    6. The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.
      Title: Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China.
    7. GPx3 methylation may have implications in chemotherapy response and clinical outcome of head and neck cancer patients
      Title: GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response.
    8. Genetic variants of GPX3 are risk factors for arterial stroke, but not for thromboembolic arterial ischemic stroke or cerebral sinovenous thrombosis in children.
      Title: Plasma glutathione peroxidase in pediatric stroke families.
    9. GPX3 protein expression was significantly lower in esophageal squamous cell carcinoma than in adjacent nontumor tissues. In esophageal squamous cell carcinoma, GPX3 was downregulated through promoter hypermethylation.
      Title: Identification of GPX3 epigenetically silenced by CpG methylation in human esophageal squamous cell carcinoma.
    10. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
    Submit: New GeneRIF Correction See all (34)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Tat, p14 tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
    tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:109136 BioGRID:109136 GPX3    BioGRID  PubMed Co-purification 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    selenium binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    hydrogen peroxide catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to lipid hydroperoxide TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    glutathione peroxidase 3
    Names
    glutathione peroxidase 3
    GPx-3
    plasma glutathione peroxidase
    extracellular glutathione peroxidase
    NP_002075.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002084.3 → NP_002075.2  glutathione peroxidase 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008641, AL036834, BI522602
      Consensus CDS
      CCDS43389.1
      UniProtKB/Swiss-Prot
      P22352
      Related
      ENSP00000373477, OTTHUMP00000224545, ENST00000388825, OTTHUMT00000374772
      Conserved Domains (1) summary
      cd00340
      Location:39 – 211
      Blast Score: 462
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      150399999..150408554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      145545808..145554363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      150676115..150684670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01026268.1 (78463..87018) None
    genomic AC008641.7 (14333..22963) None
    genomic AMYH01015710.1 (336928..345483) None
    genomic AY310878.1 AAP50261.1
    genomic CH471062.2 EAW61692.1
      EAW61693.1
    genomic D16360.1 BAA03862.1
    genomic D16361.1 BAA03863.2
    genomic D16362.1 BAA03864.1
    mRNA AF217787.1 AAF43005.1
    mRNA AK310242.1 None
    mRNA AL036834.2 None
    mRNA BC013218.1 None
    mRNA BC013601.1 AAH13601.1
    mRNA BC025956.1 None
    mRNA BC035841.1 AAH35841.1
    mRNA BC050378.1 AAH50378.2
    mRNA BC066949.1 AAH66949.1
    mRNA BI522602.1 None
    mRNA D00632.1 BAA00525.1
    mRNA X58295.1 CAA41228.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22352.2 GenPept UniProtKB/Swiss-Prot:P22352

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...