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    GPS1 G protein pathway suppressor 1 [ Homo sapiens ]

    Gene ID: 2873, updated on 11-May-2012
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    Summary

    Official Symbol
    GPS1provided by HGNC
    Official Full Name
    G protein pathway suppressor 1provided by HGNC
    Primary source
    HGNC:4549
    See related
    Ensembl:ENSG00000169727; HPRD:15991; MIM:601934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSN1; COPS1; MGC71287
    Summary
    This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q25.3
    Sequence :
    Chromosome: 17; NC_000017.10 (80009763..80015346)
    See GPS1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene dicarbonyl/L-xylulose reductase Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene fatty acid synthase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Tsuge T, et al. Protein Cell, 2011 May. PMID 21604193.

    See all (34) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
      Title: CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
    2. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome.
      Title: The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAC50906.2 NP_004227.1 COPS2    BIND  PubMed CSN1 interacts with CSN2. 
    AAC50906.2 AAD43021.1 COPS4    BIND  PubMed CSN1 interacts with CSN4. 
    Q13098 P61201 COPS2    HPRD  PubMed  
    Q13098 Q9UNS2 COPS3    HPRD  PubMed  
    Q13098 Q92905 COPS5    HPRD  PubMed  
    Q13098 Q7L5N1 COPS6    HPRD  PubMed  
    Q13098 Q9UBW8 COPS7A    HPRD  PubMed  
    Q13098 Q99627 COPS8    HPRD  PubMed  
    Q13098 Q13616 CUL1    HPRD  PubMed  
    Q13098 Q13617 CUL2    HPRD  PubMed  
    Q13098 Q13618 CUL3    HPRD  PubMed  
    Q13098 Q93034 CUL5    HPRD  PubMed  
    Q13098 Q13572 ITPK1    HPRD  PubMed  
    Q13098 P62877 RBX1    HPRD  PubMed  
    Q13098 P63208 SKP1    HPRD  PubMed  
    Q13098 Q13309 SKP2    HPRD  PubMed  
    Q13098 Q9HA65 TBC1D17    HPRD  PubMed  
    Q13098 P04637 TP53    HPRD  PubMed  
    BioGRID:109131 BioGRID:124073 CARD11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109131 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:116124 COPS8    BioGRID  PubMed Co-purification 
    BioGRID:109131 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109131 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:199074 Ddb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:109871 IRF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:109621 IRF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:116098 MALT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109131 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109131 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the GPS1 gene: The GPS1 gene is conserved in chimpanzee, , dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    JNK cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cullin deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inactivation of MAPK activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    COP9 signalosome complex subunit 1
    SGN1
    GPS-1
    signalosome subunit 1
    JAB1-containing signalosome subunit 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004127.4 → NP_004118.3  COP9 signalosome complex subunit 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' region and uses an upstream translation start codon, as compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC000155, BC064503, BG775520
      Consensus CDS
      CCDS32774.1
      UniProtKB/Swiss-Prot
      Q13098
      Related
      ENSP00000302873, ENST00000306823
      Conserved Domains (2) summary
      pfam10602
      Location:127 – 309
      Blast Score: 540
      RPN7; 26S proteasome subunit RPN7
      cl02111
      Location:326 – 425
      Blast Score: 207
      PCI; PCI domain

    2. NM_212492.1 → NP_997657.1  COP9 signalosome complex subunit 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC064503, BG775520
      Consensus CDS
      CCDS11800.1
      UniProtKB/Swiss-Prot
      Q13098
      Related
      ENSP00000376167, ENST00000392358
      Conserved Domains (2) summary
      pfam10602
      Location:163 – 345
      Blast Score: 538
      RPN7; 26S proteasome subunit RPN7
      cl02111
      Location:362 – 461
      Blast Score: 209
      PCI; PCI domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      80009763..80015346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      75409883..75415466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC135056.4 (18248..23831) None
    genomic CH471099.1 EAW89741.1
      EAW89742.1
    mRNA AB209596.1 BAD92833.1
    mRNA AK026610.1 None
    mRNA AK093283.1 BAC04120.1
    mRNA AK222508.1 None
    mRNA AK225248.1 None
    mRNA AK289435.1 BAF82124.1
    mRNA AK297872.1 BAG60198.1
    mRNA BC000155.2 AAH00155.3
    mRNA BC064503.1 AAH64503.1
    mRNA BG775520.1 None
    mRNA BT009834.1 AAP88836.1
    mRNA U20285.2 AAC50906.2
    other-genetic EU832312.1 ACE87569.1
    other-genetic EU832397.1 ACE86882.1
    other-genetic HQ258557.1 ADR83311.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13098.4 GenPept UniProtKB/Swiss-Prot:Q13098
    Q59F65 GenPept UniProtKB/TrEMBL:Q59F65
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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