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    GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]

    Gene ID: 2869, updated on 11-May-2012
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    Summary

    Official Symbol
    GRK5provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 5provided by HGNC
    Primary source
    HGNC:4544
    See related
    Ensembl:ENSG00000198873; HPRD:02926; MIM:600870; Vega:OTTHUMG00000019149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRK5; FLJ39780
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    10q26.11
    Sequence :
    Chromosome: 10; NC_000010.10 (120967197..121215131)
    See GRK5 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3 Neighboring gene microRNA 4681 Neighboring gene regulator of G-protein signaling 10 Neighboring gene TIA1 cytotoxic granule-associated RNA binding protein-like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression. Michal AM, et al. J Biol Chem, 2012 Feb 24. PMID 22223642.
    2. Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure. Agüero J, et al. J Card Fail, 2012 Jan. PMID 22196842.
    3. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Zhang Y, et al. Circ Heart Fail, 2011 Sep. PMID 21768220.
    4. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Barker BL, et al. Biochemistry, 2011 Aug 16. PMID 21728385.
    5. G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells. Wu CC, et al. BMC Cancer, 2011 May 17. PMID 21575264.

    See all (61) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Increased GRK5 expression in the failing myocardium suggests a relevant role in human heart failure.
      Title: Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure.
    2. GRK5 is localized in the centrosome and regulates microtubule nucleation and normal cell cycle progression.
      Title: G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.
    3. GRK5 is a transcriptional modifier of a subset of Galphaq-downregulated genes, acting in opposition to the pathological effects of Galphaq and normalizing levels of these transcripts.
      Title: Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure.
    4. Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization
      Title: G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.
    5. GRK5 mediates cell growth suppression by TIG1A. Thus, TIG1 may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression.
      Title: G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells.
    6. GRK5 gene does not confer risk to sporadic Parkinson's disease in our sample from Southern Italy.
      Title: Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease.
    7. The GRK5 Leu41 allele protects from adverse cardiovascular outcomes in treated hypertensives.
      Title: Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients.
    8. Studies seem to indicate that mild, soluble, Beta-amyloid accumulation can lead to a reduced membrane (functional) and an elevated cytosolic GRK2/5.
      Title: Dysfunction of G protein-coupled receptor kinases in Alzheimer's disease.
    9. This study shows for the first time that GRK5 negatively regulates VEGF signaling in human coronary artery endothelial cells.
      Title: Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5.
    10. GRK5 as a novel kinase of p53, as well as a negative regulator of p53-mediated signal transduction.
      Title: G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
    Submit: New GeneRIF Correction See all (29)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P34947 P07550 ADRB2    HPRD  PubMed  
    P34947 P30556 AGTR1    HPRD  PubMed  
    P34947 P37288 AVPR1A    HPRD  PubMed  
    P34947 P47901 AVPR1B    HPRD  PubMed  
    P34947 P30518 AVPR2    HPRD  PubMed  
    P34947 P30411 BDKRB2    HPRD  PubMed  
    P34947 Q03135 CAV1    HPRD  PubMed  
    P34947 P08172 CHRM2    HPRD  PubMed  
    P34947 Q9P1A6 DLGAP2    HPRD  PubMed  
    P34947 Q9Y2X7 GIT1    HPRD  PubMed  
    P34947 P34947 GRK5    HPRD  PubMed  
    P34947 P35243 RCVRN    HPRD  PubMed  
    P34947 P08100 RHO    HPRD  PubMed  
    P34947 P37840 SNCA    HPRD  PubMed  
    P34947 Q16143 SNCB    HPRD  PubMed  
    P34947 O76070 SNCG    HPRD  PubMed  
    P34947 P25103 TACR1    HPRD  PubMed  
    P34947 P21731 TBXA2R    HPRD  PubMed  
    BioGRID:109127 BioGRID:106691 AGTR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109127 BioGRID:107033 AVPR1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109127 BioGRID:107035 AVPR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109127 BioGRID:114863 CABP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109127 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109127 BioGRID:107305 CAV1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109127 BioGRID:109127 GRK5    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:111061 OXTR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109127 BioGRID:111890 RCVRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109127 BioGRID:111942 RHO    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:159869 SNCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:112506 SNCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:112504 SNCB    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:112507 SNCG    BioGRID  PubMed Biochemical Activity 
    BioGRID:109127 BioGRID:112732 TACR1    BioGRID  PubMed Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    G-protein coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    G-protein signaling, coupled to cAMP nucleotide second messenger TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		  
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of G-protein coupled receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    tachykinin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    termination of G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    soluble fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    G protein-coupled receptor kinase 5
    Names
    G protein-coupled receptor kinase 5
    FP2025
    g protein-coupled receptor kinase GRK5
    NP_005299.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005308.2 → NP_005299.1  G protein-coupled receptor kinase 5

      Status: REVIEWED

      Source sequence(s)
      BC018116, BC064506, BQ184611, CN290123, L15388
      Consensus CDS
      CCDS7612.1
      UniProtKB/Swiss-Prot
      P34947
      Related
      ENSP00000376609, OTTHUMP00000020596, ENST00000392870, OTTHUMT00000050652
      Conserved Domains (4) summary
      cd05605
      Location:185 – 469
      Blast Score: 1440
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases
      cd08752
      Location:53 – 175
      Blast Score: 637
      RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
      smart00220
      Location:186 – 448
      Blast Score: 644
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl11395
      Location:449 – 514
      Blast Score: 86
      Pkinase_C; Protein kinase C terminal domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      120967197..121215131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      114596405..114842644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL355273.30 CAI16487.1
    genomic AL355861.19 CAI15804.1
    genomic AL583824.16 CAI16759.1
    genomic CH471066.2 EAW49393.1
      EAW49394.1
      EAW49395.1
    genomic HI179064.1 CBX53840.1
    mRNA AF370369.1 AAQ15205.1
    mRNA AK097099.1 None
    mRNA AK298261.1 BAG60525.1
    mRNA AK301450.1 BAG62974.1
    mRNA AK309761.1 None
    mRNA AK313012.1 BAG35847.1
    mRNA BC018116.1 None
    mRNA BC064506.1 AAH64506.1
    mRNA BC114448.1 AAI14449.1
    mRNA BQ184611.1 None
    mRNA CN290123.1 None
    mRNA L15388.1 AAA58620.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34947.1 GenPept UniProtKB/Swiss-Prot:P34947
    Q24JT8 GenPept UniProtKB/TrEMBL:Q24JT8
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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      General information

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