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    CPA1 carboxypeptidase A1 (pancreatic) [ Bos taurus (cattle) ]

    Gene ID: 286762, updated on 29-May-2013
    Symbol
    CPA1
    Full Name
    carboxypeptidase A1 (pancreatic)
    Locus tag
    BOS_4519
    See related
    BGD:BT15758; Ensembl:ENSBTAG00000046169
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Location :
    chromosome: 4
    Sequence :
    Chromosome: 4; AC_000161.1 (94943347..94949979)
    See CPA1 in MapViewer

    Chromosome 4 - AC_000161.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A5 Neighboring gene centrosomal protein 41kDa Neighboring gene microRNA mir-335 Neighboring gene mesoderm specific transcript homolog (mouse)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038.
    2. Cloning, sequencing and expression of the gene encoding a major allotypic preprocarboxypeptidase A from bovine pancreas. Goo JH, et al. Gene, 1995 Nov 20. PMID 8522204.
    3. The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C. Gomis-Rüth FX, et al. EMBO J, 1995 Sep 15. PMID 7556081.
    4. Cloning and nucleotide sequence of a bovine pancreatic preprocarboxypeptidase A cDNA. Le Huërou I, et al. Biochem Biophys Res Commun, 1991 Feb 28. PMID 1998496.
    5. The amino acid sequence of the activation peptide of bovine pro-carboxypeptidase A. Wade RD, et al. Biochimie, 1988 Sep. PMID 3147705.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    Markers

    Genotypes

    Homology

    • Homologs of the CPA1 gene: The CPA1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, and mosquito.

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    carboxypeptidase A1
    Names
    carboxypeptidase A1
    pancreatic procarboxypeptidase A
    NP_777175.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174750.2 → NP_777175.1  carboxypeptidase A1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      M61851
      UniProtKB/Swiss-Prot
      P00730
      Related
      ENSBTAP00000009745, ENSBTAT00000009745
      Conserved Domains (2) summary
      cd03870
      Location:117 – 417
      Blast Score: 1636
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:26 – 101
      Blast Score: 254
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: Build 6.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_taurus_UMD_3.1 Primary Assembly

    Genomic

    1. AC_000161.1 Reference Bos_taurus_UMD_3.1 Primary Assembly

      Range
      94943347..94949979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Btau_4.6.1

    Genomic

    1. NC_007302.5 Alternate Btau_4.6.1

      Range
      96862915..96869547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAFC03096496.1 (104292..110924) None Hereford
    genomic DAAA02011518.1 (199200..205832) None
    genomic GJ060721.1 DAA30409.1 Hereford
    mRNA BC146042.1 AAI46043.1 Hereford
    mRNA M61851.1 AAA30426.1
    mRNA Z33906.1 CAA83955.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00730.3 GenPept UniProtKB/Swiss-Prot:P00730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

        Supplemental Content

        Table of contents

        Related information

        • Order cDNA clone
          Order cDNA clone
        • 3D structures
          3D structure of a gene
        • BioAssay, by Protein Target
          BioAssay, by Protein Target
        • BioProjects
          BioProjects related to a gene
        • BioSystems
          BioSystems
        • Conserved Domains
          Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
        • Full text in PMC
          PMC links
        • Full text in PMC_nucleotide
          Full text in PubMedCentral identified from shared sequence links
        • Genome
          Genome records having the gene annotated on corresponding genomic reference sequence.
        • GEO Profiles
          Related GEO
        • HomoloGene
          Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
        • Map Viewer
          These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
        • Nucleotide
          Link to related Nucleotide entry
        • Probe
          Related Probe entry
        • Protein
          Link to related protein entry
        • PubChem Compound
          PubChem Compounds
        • PubChem Substance
          PubChem Substances
        • PubMed
          Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
        • PubMed(nucleotide/PMC)
          Citations in PubMed identified from shared sequence and PMC links.
        • RefSeq Proteins
          Link to Protein RefSeqs
        • RefSeq RNAs
          Link to Nucleotide RefSeq RNAs
        • SNP
          Related SNP records
        • SNP: GeneView
          SNPs linked from GeneView
        • Taxonomy
          Link to related taxonomy entry
        • UniGene
          Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
        • UniSTS
          Related UniSTS records

        Links to other resources

        General information

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