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P2RY8 purinergic receptor P2Y8 [ Homo sapiens (human) ]

Gene ID: 286530, updated on 29-May-2016
Official Symbol
P2RY8provided by HGNC
Official Full Name
purinergic receptor P2Y8provided by HGNC
Primary source
HGNC:HGNC:15524
See related
Ensembl:ENSG00000182162 HPRD:06671; MIM:300525; Vega:OTTHUMG00000021060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y8
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xp22.33; Yp11.3
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (1462572..1537506, complement)
107 current GRCh38.p2 (GCF_000001405.28) Y NC_000024.10 (1462572..1537506, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1581465..1656037, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1531465..1606037, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase-like Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC105373105

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase-like Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC105379415

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC50878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
P2Y purinoceptor 8
Names
G-protein coupled purinergic receptor P2Y8
purinergic receptor P2Y, G-protein coupled, 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013252.1 RefSeqGene

    Range
    5001..79573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178129.4NP_835230.1  P2Y purinoceptor 8

    See identical proteins and their annotated locations for NP_835230.1

    Status: REVIEWED

    Source sequence(s)
    AI476104, AI494365, AK092956, AL833184, BC043610, BE245848
    Consensus CDS
    CCDS14115.1
    UniProtKB/Swiss-Prot
    Q86VZ1
    Related
    ENSP00000370697, OTTHUMP00000022830, ENST00000381297, OTTHUMT00000055602
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p2 Primary Assembly

    Range
    1462572..1537506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724864.2XP_006724927.2  

    See identical proteins and their annotated locations for XP_006724927.2

    Conserved Domains (2) summary
    pfam00001
    Location:235482
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:222321
    7tm_4; Olfactory receptor
  2. XM_011545631.1XP_011543933.1  

    See identical proteins and their annotated locations for XP_011543933.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011545632.1XP_011543934.1  

    See identical proteins and their annotated locations for XP_011543934.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_005274778.2XP_005274835.1  

    See identical proteins and their annotated locations for XP_005274835.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    1462572..1537506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724443.2XP_006724506.2  

    See identical proteins and their annotated locations for XP_006724506.2

    Conserved Domains (2) summary
    pfam00001
    Location:235482
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:222321
    7tm_4; Olfactory receptor
  2. XM_011546178.1XP_011544480.1  

    See identical proteins and their annotated locations for XP_011544480.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011546179.1XP_011544481.1  

    See identical proteins and their annotated locations for XP_011544481.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_005274429.2XP_005274486.1  

    See identical proteins and their annotated locations for XP_005274486.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    pfam00001
    Location:46293
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    1612055..1686721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)