GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: GPR37provided by HGNC
Official Full Name: G protein-coupled receptor 37 (endothelin receptor type B-like)provided by HGNC
Primary source: HGNC:4494
See related: HPRD:03992; MIM:602583
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAELR; EDNRBL; hET(B)R-LP
Summary: This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Genomic context

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Location :: 7q31

Sequence :: Chromosome: 7; NC_000007.13 (124385655..124406079, complement)

See GPR37 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
GPR37 surface trafficking in heterologous cells can be greatly enhanced by N-terminal truncation, coexpression with other receptors, and coexpression with syntenin-1.
Title: GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.
Data show that GPR37 overexpression can induce cellular autophagy, which may prevent the selective degeneration of GPR37-expressing neurons, as reported for Parkinson's and related neurodegenerative diseases.
Title: Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor.
Parkin-ko/Pael-R-tg mice represents an AR-JP mouse model displaying chronic and selective loss of catecholaminergic neurons.
Title: Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss.
Glup/PACRG suppresses cell death induced by accumulation of unfolded Pael receptor and facilitates the formation of Pael-R inclusions.
Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.
These results suggest that 4-PBA suppresses ER stress by directly reducing the amount of misfolded protein, including Pael-R accumulated in the ER.
Title: Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.
results show that panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity
Title: Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
O15354	O60260	PARK2	HPRD	PubMed
O15354	Q9UNE7	STUB1	HPRD	PubMed
BioGRID:109119	BioGRID:115827	CCT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:109534	DNAJA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:109569	DNAJB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:109535	HSPA1A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109119	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:109544	HSPA8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:126421	PACRG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:109119	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:124085	SYVN1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:109119	BioGRID:112810	TCP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109119	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Pathways from BioSystems

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GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...

General gene information

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Markers

HSC24E072 (e-PCR)
- UniSTS:82516

D7S532E (e-PCR)
- UniSTS:55408

GPR37 (e-PCR)
- UniSTS:503668

RH93211 (e-PCR)
- UniSTS:84115

Homology

Homologs of the GPR37 gene: The GPR37 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: probable G-protein coupled receptor 37

Names: probable G-protein coupled receptor 37; ETBR-LP-1; endothelin B receptor-like protein 1; Parkin-associated endothelin receptor-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005302.3 → NP_005293.1 probable G-protein coupled receptor 37 precursor

Status: REVIEWED

Source sequence(s)

AF017262, BC040007, DB475687, DB495592, DB517451

Consensus CDS

CCDS5792.1

UniProtKB/TrEMBL

A4D0Y6

UniProtKB/Swiss-Prot

O15354

Conserved Domains (1) summary

pfam00001
Location:284 – 548
Blast Score: 253

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p10 Primary Assembly

Range

124385655..124406079, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

118750711..118771098, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

123775046..123795470, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018918.1 Alternate CHM1_1.0

Range

127735428..127755848, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AACC02000001.1 (3690988..3711412)	None
genomic	ABBA01057712.1 (10402..24527)	None
genomic	ABBA01057713.1	None
genomic	AC004925.1	AAD08853.1
genomic	AMYH01017908.1 (303633..324053)	None
genomic	CH236947.1	EAL24325.1
genomic	CH471070.1	EAW83613.1
genomic	Y12476.1	CAA73080.1
mRNA	AF017262.1	AAB70008.1
mRNA	AF502281.2	AAM18625.2
mRNA	BC040007.1	AAH40007.1
mRNA	DB475687.1	None
mRNA	DB495592.1	None
mRNA	DB517451.1	None
other-genetic	JF432421.1	ADZ15638.1