ANK1 ankyrin 1, erythrocytic [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ANK1provided by HGNC
Official Full Name: ankyrin 1, erythrocyticprovided by HGNC
Primary source: HGNC:492
See related: Ensembl:ENSG00000029534; HPRD:01693; MIM:612641; Vega:OTTHUMG00000150281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANK; SPH1; SPH2
Summary: Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]

Genomic context

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Location :: 8p11.1

Sequence :: Chromosome: 8; NC_000008.10 (41510744..41754280, complement)

See ANK1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The ankyrin-binding site on band 3 is located near the deoxygenated hemoglobin-binding site, therefore following deoxygenation ankyrin is displaced from band 3.
Title: Oxygen regulates the band 3-ankyrin bridge in the human erythrocyte membrane.
A tissue-specific chromatin loop brings NF-E2 and ANK1E into close proximity preventing gene silencing and mutagenesis leading to hereditary spherocytosis.
Title: A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter.
results indicate that the ANK1 locus is a new, common susceptibility locus for type 2 diabetes across different ethnic groups
Title: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
The interaction of KCTD6 with ankyrin-1 may have implications beyond muscle for hereditary spherocytosis, as KCTD6 is also present in erythrocytes, and erythrocyte ankyrin isoforms contain its mapped minimal binding site.
Title: Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.
Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24.
Title: Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24.
The Hereditary Spherocytosis mutation in the human Ankyrin-1 promoter disrupted the binding of the transcription factor TFIID, the major component of the pre-initiation complex.
Title: Genome-wide detection of a TFIID localization element from an initial human disease mutation.
cytoskeletal ankyrin family are substrates for FIH-catalyzed hydroxylations
Title: Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
a region upstream of the promoter is a barrier insulator. The region exhibited functional and structural characteristics of a barrier, including prevention of gene silencing, appropriate chromatin configuration and occupancy by barrier-associated proteins
Title: Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
Generated a library of more than 16,000 ANK-1 promoters with degenerate sequence around the dinucleotide deletion mutation and cloned the functional promoter sequences. Identified the wild type and three additional sequences, and derived a consensus.
Title: Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter.

Submit: New GeneRIF Correction See all (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.

Common variants at 10 genomic loci influence hemoglobin A&#x02081;(C) levels via glycemic and nonglycemic pathways.

Genome-wide association study of lung function decline in adults with and without asthma.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Gag, Pr55	gag	Ankyrin binds to the N-terminal region (residues 132-241) of the CA domain of HIV-1 Gag. Ankyrin decreases expression of Gag in HIV-1-infected SupT1 cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P16157	Q9UL45	BLOC1S6	HPRD	PubMed
P16157	P16070	CD44	HPRD	PubMed
P16157	P16452	EPB42	HPRD	PubMed
P16157	Q14573	ITPR3	HPRD	PubMed
P16157	P32004	L1CAM	HPRD	PubMed
P16157	Q9H094	NBPF3	HPRD	PubMed
P16157	O94856	NFASC	HPRD	PubMed
P16157	Q5VST9	OBSCN	HPRD	PubMed
P16157	Q02094	RHAG	HPRD	PubMed
P16157	P02730	SLC4A1	HPRD	PubMed
P16157	P48751	SLC4A3	HPRD	PubMed
P16157	Q13813	SPTAN1	HPRD	PubMed
P16157	Q13009	TIAM1	HPRD	PubMed
P16157	Q8WZ42	TTN	HPRD	PubMed
BioGRID:106783	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106783	BioGRID:128350	KCTD6	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:106783	BioGRID:110094	L1CAM	BioGRID	PubMed	Co-localization
BioGRID:106783	BioGRID:110815	NEDD8	BioGRID	PubMed	PCA
BioGRID:106783	BioGRID:123847	OBSCN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106783	BioGRID:111937	RHAG	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106783	BioGRID:112412	SLC4A1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106783	BioGRID:112399	SLC4A3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106783	BioGRID:112586	SPTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106783	BioGRID:112588	SPTB	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106783	BioGRID:112589	SPTBN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106783	BioGRID:112904	TGFBR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106783	BioGRID:112930	TIAM1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106783	BioGRID:113124	TTN	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106783	BioGRID:113164	UBC	BioGRID	PubMed	PCA

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
CHL1 interactions, organism-specific biosystem (from REACTOME)
CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
Neurofascin interactions, organism-specific biosystem (from REACTOME)
Neurofascin interactions, organism-specific biosystemNeurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms ident...
NrCAM interactions, organism-specific biosystem (from REACTOME)
NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...

General gene information

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Markers

RH121660 (e-PCR)
- UniSTS:134400

RH69660 (e-PCR)
- UniSTS:24338

SHGC-144984 (e-PCR)
- UniSTS:174354

D8S2039 (e-PCR)
- UniSTS:21269

STS-W88737 (e-PCR)
- UniSTS:47155

NoName (e-PCR)
- UniSTS:483649

D8S2329 (e-PCR)
- UniSTS:31321

D8S311 (e-PCR)
- UniSTS:147808

D8S329 (e-PCR)
- UniSTS:51309

G19345 (e-PCR)
- UniSTS:83323

SHGC-12309 (e-PCR)
- UniSTS:21118

RH91316 (e-PCR)
- UniSTS:91775

GDB:178523 (e-PCR)
- UniSTS:66432

SHGC-132081 (e-PCR)
- UniSTS:170634

G59696 (e-PCR)
- UniSTS:136850

D8S311 (e-PCR)
- UniSTS:50106

RH46517 (e-PCR)
- UniSTS:48571

D8S2070 (e-PCR)
- UniSTS:78046

WI-11722 (e-PCR)
- UniSTS:80368

RH45454 (e-PCR)
- UniSTS:57074

RH79857 (e-PCR)
- UniSTS:87028

G43516 (e-PCR)
- UniSTS:94973

Genotypes

See ANK1 SNP Geneview Report
See ANK1 SNP Genotype Report
See ANK1 SNP Variation Viewer Report

Homology

Homologs of the ANK1 gene: The ANK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
cytoskeletal adaptor activity	IDA Inferred from Direct Assay more info	PubMed
cytoskeletal adaptor activity	TAS Traceable Author Statement more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info
enzyme binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
spectrin binding	IDA Inferred from Direct Assay more info	PubMed
spectrin binding	IPI Inferred from Physical Interaction more info	PubMed
spectrin binding	NAS Non-traceable Author Statement more info	PubMed
structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed
structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
ER to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
axon guidance	TAS Traceable Author Statement more info
cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
erythrocyte development	IEA Inferred from Electronic Annotation more info
exocytosis	NAS Non-traceable Author Statement more info	PubMed
maintenance of epithelial cell apical/basal polarity	TAS Traceable Author Statement more info	PubMed
monovalent inorganic cation transport	IEA Inferred from Electronic Annotation more info
porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
protein targeting to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
M band	IEA Inferred from Electronic Annotation more info
basolateral plasma membrane	NAS Non-traceable Author Statement more info	PubMed
cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	NAS Non-traceable Author Statement more info	PubMed
sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
spectrin-associated cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin-1

Names: ankyrin-1; ANK-1; ankyrin-R; erythrocyte ankyrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012820.1 RefSeqGene

Range

5001..248537

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000037.3 → NP_000028.3 ankyrin-1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (3) has a distinct and one aa shorter C-terminus, compared to isoform 1.

Source sequence(s)

AB209418, AC113133, M28880, N63745, X16609

Consensus CDS

CCDS6121.1

UniProtKB/Swiss-Prot

P16157

Related

ENSP00000289734, OTTHUMP00000196861, ENST00000289734, OTTHUMT00000317298

Conserved Domains (6) summary

cd00204
Location:629 – 754
Blast Score: 342

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00218
Location:911 – 1015
Blast Score: 415

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08805
Location:1401 – 1484
Blast Score: 424

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:243 – 332
Blast Score: 258

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:404 – 457
Blast Score: 154

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:720 – 774
Blast Score: 130

Ank_5; Ankyrin repeats (many copies)
NM_001142445.1 → NP_001135917.1 ankyrin-1 isoform 10 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks multiple 5' exons, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (10) has a much shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC113133, BC014467, N63745

Consensus CDS

CCDS55227.1

UniProtKB/TrEMBL

E5RFL7
NM_001142446.1 → NP_001135918.1 ankyrin-1 isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) has an alternate upstream 5' exon, which includes an AUG start codon, and has an additional exon in the middle region, but lacks a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (9) is the longest, which has a distinct N-terminus and an internal additional segment as well as lacks a segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AB209418, AC027702, AC113133, N63745, X16609

Consensus CDS

CCDS47849.1

UniProtKB/Swiss-Prot

P16157

Conserved Domains (6) summary

cd00204
Location:662 – 787
Blast Score: 340

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00218
Location:952 – 1056
Blast Score: 416

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08805
Location:1442 – 1525
Blast Score: 425

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:276 – 365
Blast Score: 257

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:437 – 490
Blast Score: 153

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:753 – 807
Blast Score: 129

Ank_5; Ankyrin repeats (many copies)
NM_020475.2 → NP_065208.2 ankyrin-1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (4) is therefore shorter than isoform 1.

Source sequence(s)

AA404587, AB209418, AC113133, M28880, N63745, X16609

UniProtKB/Swiss-Prot

P16157

Related

ENSP00000369082, ENST00000379758

Conserved Domains (6) summary

cd00204
Location:629 – 754
Blast Score: 341

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00218
Location:911 – 1015
Blast Score: 415

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08805
Location:1401 – 1484
Blast Score: 425

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:243 – 332
Blast Score: 257

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:404 – 457
Blast Score: 154

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:720 – 774
Blast Score: 129

Ank_5; Ankyrin repeats (many copies)
NM_020476.2 → NP_065209.2 ankyrin-1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform 2.1.

Source sequence(s)

AB209418, AC113133, M28880, N63745, X16609

Consensus CDS

CCDS6119.1

UniProtKB/Swiss-Prot

P16157

Related

ENSP00000339620, OTTHUMP00000196860, ENST00000347528, OTTHUMT00000317297

Conserved Domains (6) summary

cd00204
Location:629 – 754
Blast Score: 341

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00218
Location:911 – 1015
Blast Score: 415

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08805
Location:1401 – 1484
Blast Score: 425

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:243 – 332
Blast Score: 258

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:404 – 457
Blast Score: 154

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:720 – 774
Blast Score: 130

Ank_5; Ankyrin repeats (many copies)
NM_020477.2 → NP_065210.2 ankyrin-1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame segment near to the 3' coding region, compared to variant 1. The resulting isoform (2, also referred to as isoform 2.2) is therefore shorter than isoform 1.

Source sequence(s)

AB209418, AC113133, AK126647, M28880, N63745, X16609

UniProtKB/TrEMBL

B3KX39

UniProtKB/Swiss-Prot

P16157

Conserved Domains (6) summary

cd00204
Location:629 – 754
Blast Score: 339

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00218
Location:911 – 1015
Blast Score: 414

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08805
Location:1401 – 1484
Blast Score: 428

Death_ank1; Death domain of Ankyrin-1

pfam12796
Location:243 – 332
Blast Score: 257

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:404 – 457
Blast Score: 153

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:720 – 774
Blast Score: 129

Ank_5; Ankyrin repeats (many copies)
NM_020478.4 → NP_065211.2 ankyrin-1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple 5' exons, but has an alternate 5' exon, which includes an AUG start codon, and it also has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (5, also referred to as Ank 1.5 and sAnk1) has a much shorter and distinct N-terminus and also has a distinct C-terminus, compared to isoform 1. This small isoform binds to the C-terminus of obscurin, a giant protein surrounding the contractile apparatus in striated muscle, and the binding may be essential for the proper alignment of the network sarcoplasmic reticulum.

Source sequence(s)

AC113133, AK223578, BC014467, N63745

Consensus CDS

CCDS6122.1

UniProtKB/Swiss-Prot

P16157
NM_020480.4 → NP_065213.2 ankyrin-1 isoform 7 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks multiple 5' exons and an in-frame coding exon in the 3' region, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (7) has a much shorter and distinct N-terminus, and lacks a segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC113133, BC014467, BC117121, N63745

Consensus CDS

CCDS6120.1

UniProtKB/Swiss-Prot

P16157

Related

ENSP00000403589, ENST00000457297

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p10 Primary Assembly

Range

41510744..41754280, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

40038471..40281660, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018919.1 Alternate CHM1_1.0

Range

41584721..41828155, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_020479.2: Suppressed sequence

Description

NM_020479.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_020481.2: Suppressed sequence

Description

NM_020481.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01021136.1 (6223..111938)	None
genomic	ABBA01021137.1	None
genomic	ABBA01021138.1	None
genomic	AC027702.18 (102824..116088)	None
genomic	AC113133.5 (6259..137390)	None
genomic	AMYH01018674.1 (6252..249686)	None
genomic	CH471080.2	EAW63241.1
		EAW63242.1
		EAW63243.1
		EAW63244.1
		EAW63245.1
		EAW63246.1
		EAW63247.1
		EAW63248.1
		EAW63249.1
		EAW63250.1
genomic	S82671.1	AAB46776.1
genomic	U49691.1	AAB47804.1
genomic	U50092.2	AAB47805.1
genomic	U50133.1	AAB47805.1
mRNA	AA404587.1	None
mRNA	AB209418.1	BAD92655.1
mRNA	AI167814.1	None
mRNA	AI684839.1	None
mRNA	AK126647.1	BAG54351.1
mRNA	AK129864.1	None
mRNA	AK223578.1	BAD97298.1
mRNA	BC007930.2	AAH07930.1
mRNA	BC014467.1	None
mRNA	BC030957.1	AAH30957.1
mRNA	BC117121.1	AAI17122.1
mRNA	BX647936.1	None
mRNA	F28948.1	None
mRNA	M28880.1	AAA51732.1
mRNA	N63745.1	None
mRNA	X16609.1	CAA34610.1
		CAA34611.1
other-genetic	BC156401.1	AAI56402.1
other-genetic	HQ447752.1	ADQ32237.1