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GPR35 G protein-coupled receptor 35 [ Homo sapiens (human) ]

Gene ID: 2859, updated on 26-May-2016
Official Symbol
GPR35provided by HGNC
Official Full Name
G protein-coupled receptor 35provided by HGNC
Primary source
HGNC:HGNC:4492
See related
Ensembl:ENSG00000178623 HPRD:16003; MIM:602646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
2q37.3
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (240605408..240631259)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241544825..241570676)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CAPN10 antisense RNA 1 (head to head) Neighboring gene calpain 10 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene Neighboring gene aquaporin 12B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: CAPN10

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
G-protein coupled receptor 35
Names
KYNA receptor
kynurenic acid receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195381.1NP_001182310.1  G-protein coupled receptor 35 isoform b

    See identical proteins and their annotated locations for NP_001182310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK172786, AW000832, BC095500, BM857130, DB011311
    Consensus CDS
    CCDS56174.1
    UniProtKB/Swiss-Prot
    Q9HC97
    Conserved Domains (1) summary
    pfam00001
    Location:74307
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001195382.1NP_001182311.1  G-protein coupled receptor 35 isoform b

    See identical proteins and their annotated locations for NP_001182311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK172786, AK290256, AW000832, BC095500, BM857130, DB011311
    Consensus CDS
    CCDS56174.1
    UniProtKB/Swiss-Prot
    Q9HC97
    UniProtKB/TrEMBL
    A8K2J1
    Related
    ENSP00000411788, ENST00000430267
    Conserved Domains (1) summary
    pfam00001
    Location:74307
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_005301.3NP_005292.2  G-protein coupled receptor 35 isoform a

    See identical proteins and their annotated locations for NP_005292.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a, also known as GPR35a).
    Source sequence(s)
    AC124862, AK172786, AK290256, AK314002, AW000832, BC095500
    Consensus CDS
    CCDS2541.1
    UniProtKB/Swiss-Prot
    Q9HC97
    UniProtKB/TrEMBL
    A8K2J1, B2RA17
    Related
    ENSP00000384263, OTTHUMP00000201395, ENST00000407714, OTTHUMT00000325633
    Conserved Domains (1) summary
    pfam00001
    Location:43276
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    240605408..240631259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    241550880..241576585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)