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    GPR31 G protein-coupled receptor 31 [ Homo sapiens ]

    Gene ID: 2853, updated on 11-May-2012
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    Summary

    Official Symbol
    GPR31provided by HGNC
    Official Full Name
    G protein-coupled receptor 31provided by HGNC
    Primary source
    HGNC:4486
    See related
    Ensembl:ENSG00000120436; HPRD:03622; MIM:602043; Vega:OTTHUMG00000016013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HETER; HETER1; 12-HETER
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    Genomic context

    Location :
    6q27
    Sequence :
    Chromosome: 6; NC_000006.11 (167570360..167571319, complement)
    See GPR31 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene FGFR1 oncogene partner Neighboring gene chemokine (C-C motif) receptor 6 Neighboring gene t-complex 10-like 2 (mouse) Neighboring gene unc-93 homolog A (C. elegans) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. Guo Y, et al. J Biol Chem, 2011 Sep 30. PMID 21712392.
    2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404.
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    4. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. Zingoni A, et al. Genomics, 1997 Jun 15. PMID 9205127.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. 12-HETER represents the first identified high affinity receptor for the 12-(S)-HETE hydroxyl fatty acids.
      Title: Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Genotypes

    Homology

    Pathways from BioSystems

    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    Names
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    12-(S)-HETE receptor
    12-(S)-HETE acid receptor
    G-protein coupled receptor 31
    probable G-protein coupled receptor 31
    bA517H2.2 (G protein-coupled receptor 31)
    hydroxyeicosatetraenoic (HETE) acid receptor 1
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005299.2 → NP_005290.2  12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

      Status: VALIDATED

      Source sequence(s)
      AL121935, BC095537, CD246167
      Consensus CDS
      CCDS5299.1
      UniProtKB/Swiss-Prot
      O00270
      Related
      ENSP00000355799, OTTHUMP00000017616, ENST00000366834, OTTHUMT00000043111
      Conserved Domains (1) summary
      pfam00001
      Location:80 – 282
      Blast Score: 208
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      167570360..167571319, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      165042993..165043952, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121935.17 CAB99329.1
    genomic CH471051.2 EAW47505.1
    genomic U65402.1 AAC51375.1
    mRNA BC095537.1 AAH95537.1
    mRNA CD246167.1 None
    other-genetic BC167778.1 AAI67778.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00270.2 GenPept UniProtKB/Swiss-Prot:O00270
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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