My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    EPHA6 EPH receptor A6 [ Homo sapiens ]

    Gene ID: 285220, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    EPHA6provided by HGNC
    Official Full Name
    EPH receptor A6provided by HGNC
    Primary source
    HGNC:19296
    Locus tag
    UNQ6114
    See related
    Ensembl:ENSG00000080224; MIM:600066; Vega:OTTHUMG00000159208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EK12; EPA6; PRO57066; FLJ35246; DKFZp434C1418
    Help top of page

    Genomic context

    Location :
    3q11.2
    Sequence :
    Chromosome: 3; NC_000003.11 (96533425..97467786)
    See EPHA6 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene regulator of chromosome condensation 2 pseudogene 5 Neighboring gene CDV3 homolog (mouse) pseudogene 1 Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene MYC induced nuclear antigen

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. Glessner JT, et al. Am J Hum Genet, 2010 Nov 12. PMID 20950786.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance. Kozulin P, et al. Mol Vis, 2009 Dec 9. PMID 20011078.
    4. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Ikeda M, et al. Biol Psychiatry, 2010 Feb 1. PMID 19850283.
    5. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide study reveals copy number variants exclusive to childhood obesity cases.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. During development of the retinal vasculature, migration of ligand-bearing astrocytes is slowed along Eph-A6 expression gradient through repellent Eph-A6 - ephrin-A1 and -A4 signaling.
      Title: Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance.
    4. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    EPH receptor A6 P20827 EFNA1    HPRD  PubMed  
    EPH receptor A6 P52798 EFNA4    HPRD  PubMed  
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHA forward signaling, organism-specific biosystem
      EPHA forward signaling
    • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
      EphrinA-EPHA pathway, organism-specific biosystem
      EphrinA-EPHA pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    molecular_function ND
    No biological Data available
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    ephrin type-A receptor 6
    Names
    ephrin type-A receptor 6
    EHK-2
    EPH-like kinase 12
    EPH homology kinase 2
    ephrin receptor EphA6
    NP_001073917.2
    NP_775926.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080448.2 → NP_001073917.2  ephrin type-A receptor 6 isoform a

      Status: PROVISIONAL

      Source sequence(s)
      AK092565, BC031881, BX099374, DA385338, DN991634, DR731365, DV080244
      Consensus CDS
      CCDS46876.1
      UniProtKB/TrEMBL
      B3KS12
      Related
      ENSP00000374323, OTTHUMP00000214353, ENST00000389672, OTTHUMT00000353845
      Conserved Domains (8) summary
      cd00063
      Location:537 – 628
      Blast Score: 165
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:370 – 406
      Blast Score: 96
      GCC2_GCC3; GCC2 and GCC3
      smart00454
      Location:1052 – 1119
      Blast Score: 171
      SAM; Sterile alpha motif.
      cd10484
      Location:128 – 300
      Blast Score: 983
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      pfam07714
      Location:725 – 1024
      Blast Score: 1034
      Pkinase_Tyr; Protein tyrosine kinase
      cl00065
      Location:427 – 521
      Blast Score: 116
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl15755
      Location:1055 – 1118
      Blast Score: 279
      SAM_superfamily; SAM (Sterile alpha motif )
      cl09925
      Location:720 – 1028
      Blast Score: 1452
      PKc_like; Protein Kinases, catalytic domain

    2. NM_173655.2 → NP_775926.1  ephrin type-A receptor 6 isoform b

      Status: PROVISIONAL

      Source sequence(s)
      AL133666
      Consensus CDS
      CCDS54616.1
      UniProtKB/Swiss-Prot
      Q9UF33
      Related
      ENSP00000423950, OTTHUMP00000217916, ENST00000502694, OTTHUMT00000359996
      Conserved Domains (1) summary
      cl09925
      Location:112 – 320
      Blast Score: 864
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      96533425..97467786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      93902924..94837692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107482.2 (25477..178615) None
    genomic AC108714.3 None
    genomic AC109782.7 None
    genomic AC110717.11 None
    genomic AC117439.5 None
    genomic AC117470.8 (2004..190629) None
    genomic AC119745.2 None
    genomic AC130510.3 (2004..62403) None
    genomic AC134730.2 None
    genomic AC135369.2 (4678..12744) None
    genomic CH471052.2 EAW79885.1
    genomic HC006940.1 CBH19275.1
    mRNA AK092565.1 BAG52574.1
    mRNA AK302040.1 BAG63434.1
    mRNA AK302080.1 BAG63468.1
    mRNA AK310249.1 None
    mRNA AL133666.1 CAB63775.1
    mRNA AY358738.1 AAQ89098.1
    mRNA BC031881.1 None
    mRNA BC067287.1 None
    mRNA BX099374.1 None
    mRNA DA385338.1 None
    mRNA DN991634.1 None
    mRNA DR731365.1 None
    mRNA DV080244.1 None
    other-genetic BC156733.1 AAI56734.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWM0 GenPept UniProtKB/TrEMBL:Q6UWM0
    Q9UF33.2 GenPept UniProtKB/Swiss-Prot:Q9UF33
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...