My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    GPER G protein-coupled estrogen receptor 1 [ Homo sapiens ]

    Gene ID: 2852, updated on 20-May-2012
    Help top of page

    Summary

    Official Symbol
    GPERprovided by HGNC
    Official Full Name
    G protein-coupled estrogen receptor 1provided by HGNC
    Primary source
    HGNC:4485
    See related
    Ensembl:ENSG00000164850; HPRD:03484; MIM:601805; Vega:OTTHUMG00000023680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEPR; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br; MGC99678
    Summary
    This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    7p22.3
    Sequence :
    Chromosome: 7; NC_000007.13 (1126443..1133451)
    See GPER in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene chromosome 7 open reading frame 50 Neighboring gene uncharacterized LOC100505551 Neighboring gene uncharacterized LOC100505568 Neighboring gene G protein-coupled receptor 146 Neighboring gene zinc finger, AN1-type domain 2A Neighboring gene UNC homeobox

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen. Lindsey SH, et al. Gend Med, 2011 Dec. PMID 22153880.
    2. Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERα36 induction. Wallacides A, et al. Mol Cell Endocrinol, 2012 Mar 5. PMID 22138413.
    3. Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation. Wei Y, et al. Oncol Rep, 2012 Feb. PMID 22075757.
    4. Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes. Rago V, et al. Reprod Biol Endocrinol, 2011 Oct 5. PMID 21974818.
    5. Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. Yu X, et al. Am J Physiol Endocrinol Metab, 2011 Nov. PMID 21791623.

    See all (74) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Estrogens act through a GPER-dependent signalling pathway.
      Title: Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERα36 induction.
    2. This review takes an organ-based approach to assess the expression and function of GPR30 in the cardiovascular system. (review)
      Title: Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen.
    3. regulation of proliferation in nuclear ER-positive endometrial cancer cells is mediated by both ER-Notch signaling and GPR30-PI3K/AKT signaling.
      Title: Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation.
    4. GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma
      Title: Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms.
    5. Results suggest GPER is expressed in cytoplasm of non-neoplastic testes and neoplastic testes (including granuloma, Sertoli cell tumor, Leydig cell tumor, seminoma, and embryonal carcinoma).
      Title: Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes.
    6. GPER activation relaxes coronary artery smooth muscle by increasing potassium efflux via BK(Ca) channels and requires an intact cellular signaling mechanism.
      Title: Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle.
    7. lower in endometrium of polycystic ovary syndrome group compared to controls
      Title: Expression of GPR30, ERα and ERβ in endometrium during window of implantation in patients with polycystic ovary syndrome: a pilot study.
    8. GRp30-activated membrane estrogen receptors mediate increased contractility of the human myometrium.
      Title: G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium.
    9. High GPR30 is associated with tamoxifen resistance in breast cancer.
      Title: G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer.
    10. the subcellular localization pattern of GPR30 in different tissues
      Title: Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus.
    Submit: New GeneRIF Correction See all (45)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001496.1     BIND  PubMed E2 interacts with GPR30. 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Estrogen signaling pathway, organism-specific biosystem (from WikiPathways)
      Estrogen signaling pathway, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17??-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    G-protein coupled estrogen receptor 1
    Names
    G-protein coupled estrogen receptor 1
    mER
    heptahelix receptor
    chemokine receptor-like 2
    IL8-related receptor DRY12
    membrane estrogen receptor
    G protein-coupled receptor 30
    G-protein coupled receptor 30
    chemoattractant receptor-like 2
    leucine rich protein in GPR30 3'UTR
    lymphocyte-derived G-protein coupled receptor
    constitutively expressed peptide-like receptor
    flow-induced endothelial G-protein coupled receptor 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039966.1 → NP_001035055.1  G-protein coupled estrogen receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 2, 3, and 4 encode the same protein.
      Source sequence(s)
      BC082766, BM672716, DA014990, U63917
      Consensus CDS
      CCDS5322.1
      UniProtKB/TrEMBL
      Q63ZY2
      UniProtKB/Swiss-Prot
      Q99527
      Related
      ENSP00000380281, ENST00000397092
      Conserved Domains (1) summary
      pfam00001
      Location:82 – 324
      Blast Score: 359
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001098201.1 → NP_001091671.1  G-protein coupled estrogen receptor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 2, 3, and 4 encode the same protein.
      Source sequence(s)
      BC082766, BM672716, DC381205, U63917
      Consensus CDS
      CCDS5322.1
      UniProtKB/TrEMBL
      Q63ZY2
      UniProtKB/Swiss-Prot
      Q99527
      Related
      ENSP00000380277, OTTHUMP00000115502, ENST00000397088, OTTHUMT00000206886
      Conserved Domains (1) summary
      pfam00001
      Location:82 – 324
      Blast Score: 359
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001505.2 → NP_001496.1  G-protein coupled estrogen receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AF015257, BC082766, BM672716, DA014990
      Consensus CDS
      CCDS5322.1
      UniProtKB/TrEMBL
      Q63ZY2
      UniProtKB/Swiss-Prot
      Q99527
      Related
      ENSP00000297469, OTTHUMP00000025298, ENST00000297469, OTTHUMT00000060001
      Conserved Domains (1) summary
      pfam00001
      Location:82 – 324
      Blast Score: 359
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      1126443..1133451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      1041713..1048693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      1180870..1187850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001031682.1: Suppressed sequence

      Description
      NM_001031682.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091729.4 (13730..20669) None
    genomic AF007171.1 None
    genomic AF027956.1 AAC52027.1
    genomic CH236953.1 EAL23938.1
    genomic CH471144.1 EAW87194.1
      EAW87195.1
    genomic U77827.1 AAC51173.1
    mRNA AB451427.1 BAG70241.1
    mRNA AF015257.1 AAC51904.1
    mRNA AK289588.1 BAF82277.1
    mRNA AY265807.1 AAP40320.1
    mRNA AY265808.1 AAP40321.1
    mRNA AY265809.1 AAP40322.1
    mRNA BC011634.1 AAH11634.1
    mRNA BC067849.1 None
    mRNA BC082766.1 AAH82766.1
    mRNA BM672716.1 None
    mRNA CR541655.1 CAG46456.1
    mRNA CR541741.1 CAG46541.1
    mRNA DA014990.1 None
    mRNA DC381205.1 None
    mRNA U58828.1 AAB02736.1
    mRNA U63917.1 AAB88017.1
    mRNA X98510.1 CAA67133.1
    mRNA Y08162.1 CAA69354.1
    other-genetic DQ891902.2 ABM82828.1
    other-genetic DQ895088.2 ABM86014.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63ZY2 GenPept UniProtKB/TrEMBL:Q63ZY2
    Q6FHU6 GenPept UniProtKB/TrEMBL:Q6FHU6
    Q7Z7A7 GenPept UniProtKB/TrEMBL:Q7Z7A7
    Q7Z7A8 GenPept UniProtKB/TrEMBL:Q7Z7A8
    Q7Z7A9 GenPept UniProtKB/TrEMBL:Q7Z7A9
    Q99527.1 GenPept UniProtKB/Swiss-Prot:Q99527
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...