DLL1 delta-like 1 (Drosophila) [Homo sapiens] - Gene

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Summary

Official Symbol: DLL1provided by HGNC
Official Full Name: delta-like 1 (Drosophila)provided by HGNC
Primary source: HGNC:2908
Locus tag: UNQ146/PRO172
See related: Ensembl:ENSG00000198719; HPRD:05957; MIM:606582; Vega:OTTHUMG00000016078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DL1; Delta; DELTA1
Summary: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6q27

Sequence :: Chromosome: 6; NC_000006.11 (170591294..170599697, complement)

See DLL1 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

as compared to MSC, OP9 cells were more efficient at inducing self-renewal and/or de novo generation of primitive (CD34(+) CD38(-) Lin(-)) cells, and suggest that such effects were due, at least in part, to the presence of Jagged-1 and DL1.
Title: In vitro effects of stromal cells expressing different levels of Jagged-1 and Delta-1 on the growth of primitive and intermediate CD34(+) cell subsets from human cord blood.
An anti-delta1 Notch protein-blocking monoclonal antibody is able to prolong allograft survival in a fully histocompatibility-mismatched model of cardiac transplantation.
Title: Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation.
growth rate of Delta1-deficient dental pulp stem cells was significantly suppressed as compared with wild type cells
Title: Inhibition of Delta1 promotes differentiation of odontoblasts and inhibits proliferation of human dental pulp stem cell in vitro.
The receptors Notch2, -3, -4 and their ligands Jagged1, -2 and Delta1, -4 were detected at both the mRNA and protein level in early and late placenta
Title: Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.
The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner.
Title: Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.
Notch1 and its ligand Delta-like 1(DLL1) are miR-449 bona fide targets
Title: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.
findings implicate DLL1 in early patterning of the forebrain and identify NOTCH as a new signaling pathway involved in Holoprosencephaly.
Title: NOTCH, a new signaling pathway implicated in holoprosencephaly.
In this study, Delta 1 ligand was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch pathway activation in those cells.
Title: Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts.
Delta1 protein is involved in the cytodifferentiation of squamous odontogenic tumors of the mandible.
Title: Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.
revealed a striking difference between the responses of Notch to trans- and cis-Delta: whereas the response to trans-Delta is graded, the response to cis-Delta is sharp and occurs at a fixed threshold, independent of trans-Delta
Title: Cis-interactions between Notch and Delta generate mutually exclusive signalling states.

Submit: New GeneRIF Correction See all (36)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005609.2	NP_004733.1	MAGI1	BIND	PubMed	Delta1 interacts with MAGI-1.
O00548	O14672	ADAM10	HPRD	PubMed
O00548	MAGI1	CNKSR3	HPRD	PubMed
O00548	O00548	DLL1	HPRD	PubMed
O00548	Q86UL8	MAGI2	HPRD	PubMed
O00548	O00587	MFNG	HPRD	PubMed
O00548	P46531	NOTCH1	HPRD	PubMed
O00548	Q04721	NOTCH2	HPRD	PubMed
O00548	Q9UM47	NOTCH3	HPRD	PubMed
O00548	P48745	NOV	HPRD	PubMed
O00548	Q9H488	POFUT1	HPRD	PubMed
O00548	P49768	PSEN1	HPRD	PubMed
BioGRID:118391	BioGRID:121593	MIB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:118391	BioGRID:110913	NOTCH1	BioGRID	PubMed	Reconstituted Complex
BioGRID:118391	BioGRID:110915	NOTCH2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:118391	BioGRID:110916	NOTCH3	BioGRID	PubMed	Reconstituted Complex
BioGRID:118391	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
Notch binding	IPI Inferred from Physical Interaction more info	PubMed
calcium ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Notch receptor processing	TAS Traceable Author Statement more info
Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Notch signaling pathway	NAS Non-traceable Author Statement more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info
cell differentiation	TAS Traceable Author Statement more info	PubMed
cell fate determination	NAS Non-traceable Author Statement more info	PubMed
cell-cell signaling	IEA Inferred from Electronic Annotation more info
compartment pattern specification	IEA Inferred from Electronic Annotation more info
determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
inner ear development	IEA Inferred from Electronic Annotation more info
loop of Henle development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
neuronal stem cell maintenance	IEP Inferred from Expression Pattern more info	PubMed
proximal tubule development	IEA Inferred from Electronic Annotation more info
regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
somite specification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
integral to plasma membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: delta-like protein 1

Names: delta-like protein 1; H-Delta-1; drosophila Delta homolog 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027940.1 RefSeqGene

Range

5001..13404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005618.3 → NP_005609.3 delta-like protein 1 precursor

Status: REVIEWED

Source sequence(s)

AY358892, DA243552, DR000029

Consensus CDS

CCDS5313.1

UniProtKB/Swiss-Prot

O00548

Related

ENSP00000355718, OTTHUMP00000017690, ENST00000366756, OTTHUMT00000043254

Conserved Domains (4) summary

cd00054
Location:329 – 364
Blast Score: 110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:21 – 95
Blast Score: 301

MNNL; N terminus of Notch ligand

pfam01414
Location:159 – 221
Blast Score: 272

DSL; Delta serrate ligand

cl09941
Location:486 – 517
Blast Score: 78

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

170591294..170599697, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

168098039..168106439, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF222310.1	AAG09716.1
genomic	AL078605.30	CAB89569.1
genomic	CH471051.2	EAW47425.1
mRNA	AF196571.1	AAF05834.1
mRNA	AK314234.1	BAG36904.1
mRNA	AY358892.1	AAQ89251.1
mRNA	BC028096.1	None
mRNA	DA243552.1	None
mRNA	DR000029.1	None
other-genetic	BC152803.1	AAI52804.1