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NKIRAS2 NFKB inhibitor interacting Ras like 2 [ Homo sapiens (human) ]

Gene ID: 28511, updated on 26-May-2016
Official Symbol
NKIRAS2provided by HGNC
Official Full Name
NFKB inhibitor interacting Ras like 2provided by HGNC
Primary source
HGNC:HGNC:17898
See related
Ensembl:ENSG00000168256 HPRD:07261; MIM:604497; Vega:OTTHUMG00000133503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KBRAS2; kappaB-Ras2
Orthologs
Location:
17q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (42017561..42025641)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40169594..40177659)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene uncharacterized LOC105376837 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene zinc finger protein 385C Neighboring gene uncharacterized LOC105371780 Neighboring gene DEXH-box helicase 58

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC74742, DKFZp434N1526

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling NAS
Non-traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 2
Names
I-kappa-B-interacting Ras-like protein 2
NFKB inhibitor interacting Ras-like 2
NFKB inhibitor interacting Ras-like protein 2
kappa B-Ras protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001349.2NP_001001349.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001001349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC063498
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000303580, OTTHUMP00000164768, ENST00000307641, OTTHUMT00000257457
    Conserved Domains (2) summary
    pfam00071
    Location:6168
    Ras; Ras family
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001144927.1NP_001138399.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001138399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC063498, BG717103, DA607452
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377459, OTTHUMP00000164765, ENST00000393881, OTTHUMT00000257450
    Conserved Domains (2) summary
    pfam00071
    Location:6168
    Ras; Ras family
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001144928.1NP_001138400.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001138400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC105024, AK297975, BC063498, BG717103
    Consensus CDS
    CCDS45679.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    Related
    ENSP00000401976, OTTHUMP00000164766, ENST00000449471, OTTHUMT00000257453
    Conserved Domains (2) summary
    pfam00071
    Location:6112
    Ras; Ras family
    cl21455
    Location:6112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001144929.1NP_001138401.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform c

    See identical proteins and their annotated locations for NP_001138401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform c) with a novel C-terminus, compared to isoform a.
    Source sequence(s)
    AC105024, BC063498, BG717103, DA509824
    Consensus CDS
    CCDS45680.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    Related
    ENSP00000465633, OTTHUMP00000263345, ENST00000479407, OTTHUMT00000257454
    Conserved Domains (2) summary
    cd00882
    Location:852
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
    COG1100
    Location:349
    Gem1; GTPase SAR1 family domain [General function prediction only]
  5. NM_017595.5NP_060065.2  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_060065.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC007316, BC063498, BG717103
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377463, OTTHUMP00000164763, ENST00000393885, OTTHUMT00000257448
    Conserved Domains (2) summary
    pfam00071
    Location:6168
    Ras; Ras family
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    42017561..42025641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524680.1XP_011522982.1  

    Conserved Domains (1) summary
    cl21455
    Location:60203
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011524681.1XP_011522983.1  

    Conserved Domains (1) summary
    cl21455
    Location:89147
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011524682.1XP_011522984.1  

    See identical proteins and their annotated locations for XP_011522984.1

    Related
    ENSP00000468245, OTTHUMP00000263343, ENST00000587337, OTTHUMT00000449771
    Conserved Domains (1) summary
    cl21455
    Location:4134
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_005257251.1XP_005257308.1  

    See identical proteins and their annotated locations for XP_005257308.1

    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377458, OTTHUMP00000164764, ENST00000393880, OTTHUMT00000257449
    Conserved Domains (2) summary
    pfam00071
    Location:6168
    Ras; Ras family
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    40405335..40413399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)