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    EPHA10 EPH receptor A10 [ Homo sapiens ]

    Gene ID: 284656, updated on 11-May-2012

    Summary

    Official Symbol
    EPHA10provided by HGNC
    Official Full Name
    EPH receptor A10provided by HGNC
    Primary source
    HGNC:19987
    See related
    Ensembl:ENSG00000183317; HPRD:08163; MIM:611123; Vega:OTTHUMG00000004325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ16103; FLJ33655; MGC43817
    Summary
    Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

    Genomic context

    Location :
    1p34.3
    Sequence :
    Chromosome: 1; NC_000001.10 (38181646..38230824, complement)
    See EPHA10 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 109 Neighboring gene cell division cycle associated 8 Neighboring gene alpha-actinin-4-like Neighboring gene methyltransferase like 21D pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane-ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral to membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ephrin type-A receptor 10
    Names
    ephrin type-A receptor 10
    EphA10s protein
    NP_001092909.1
    NP_775912.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099439.1NP_001092909.1  ephrin type-A receptor 10 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC104336, AJ872185, BC039363, BC041360
      Consensus CDS
      CCDS41305.1
      UniProtKB/TrEMBL
      Q4G0R4
      Related
      ENSP00000362139, OTTHUMP00000232296, ENST00000373048, OTTHUMT00000012497
      Conserved Domains (5) summary
      cd00063
      Location:451535
      Blast Score: 128
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05064
      Location:639904
      Blast Score: 1297
      PTKc_EphR_A10; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
      cd09549
      Location:929992
      Blast Score: 320
      SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
      pfam07714
      Location:645900
      Blast Score: 755
      Pkinase_Tyr; Protein tyrosine kinase
      cl02704
      Location:35210
      Blast Score: 868
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    2. NM_173641.2NP_775912.2  ephrin type-A receptor 10 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AJ781169, AK090974, BC067734
      Consensus CDS
      CCDS425.1
      UniProtKB/Swiss-Prot
      Q5JZY3
      UniProtKB/TrEMBL
      Q8N289
      Related
      ENSP00000316395, OTTHUMP00000004519, ENST00000319637, OTTHUMT00000012500
      Conserved Domains (1) summary
      cl02704
      Location:35210
      Blast Score: 851
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      38181646..38230824, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      36298901..36347866, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004338.2: Suppressed sequence

      Description
      NM_001004338.2: This RefSeq was permanently suppressed because the encoded protein is partial, and it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104336.2 (34535..85763) None
    genomic AJ872185.1 CAI43321.1
    genomic CH471059.2 EAX07321.1
      EAX07322.1
      EAX07323.1
    mRNA AJ781169.1 CAG77605.1
    mRNA AK090974.1 BAC03561.1
    mRNA AK131215.1 BAD18404.1
    mRNA AK309089.1 None
    mRNA AY726560.1 None
    mRNA BC039363.1 None
    mRNA BC041360.1 AAH41360.1
    mRNA BC067734.1 AAH67734.1
    mRNA BC112933.1 AAI12934.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0R4 GenPept UniProtKB/TrEMBL:Q4G0R4
    Q5JZY3.1 GenPept UniProtKB/Swiss-Prot:Q5JZY3
    Q6ZNH1 GenPept UniProtKB/TrEMBL:Q6ZNH1
    Q8N289 GenPept UniProtKB/TrEMBL:Q8N289

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