LPAR4 lysophosphatidic acid receptor 4 [Homo sapiens] - Gene

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Summary

Official Symbol: LPAR4provided by HGNC
Official Full Name: lysophosphatidic acid receptor 4provided by HGNC
Primary source: HGNC:4478
See related: Ensembl:ENSG00000147145; HPRD:02099; MIM:300086
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPA4; P2Y9; GPR23; P2RY9; P2Y5-LIKE
Summary: This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]

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Genomic context

Location :: Xq21.1

Sequence :: Chromosome: X; NC_000023.10 (78003206..78012588)

See LPAR4 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LPA4 gene mutation may play some role in the pathogenesis of colon cancer.
Title: Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells
Title: LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
Title: Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
identified as the fourth lysophosphatidic acid (LPA) receptor; shares only 20-24% amino acid identities with Edg-2/LPA1, Edg-4/LPA2, and Edg-7/LPA3, and phylogenetic analysis also shows that p2y9/GPR23 is far distant from the Edg family
Title: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:109105	BioGRID:107076	BCL6		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
G-protein coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
lipid binding	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: lysophosphatidic acid receptor 4

Names: lysophosphatidic acid receptor 4; LPA-4; LPA receptor 4; P2Y purinoceptor 9; P2Y5-like receptor; purinergic receptor 9; G protein-coupled receptor 23; G-protein coupled receptor 23

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013242.1 RefSeqGene

Range

5001..14383

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005296.2 → NP_005287.1 lysophosphatidic acid receptor 4

Status: REVIEWED

Source sequence(s)

AA424772, AK314134, BM973092, BX100826, DA735126, U90322

Consensus CDS

CCDS14441.1

UniProtKB/Swiss-Prot

Q99677

Related

ENSP00000408205, ENST00000435339

Conserved Domains (2) summary

pfam00001
Location:62 – 311
Blast Score: 484

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:51 – 165
Blast Score: 89

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

78003206..78012588

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

71584019..71593185

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF005419.1	AAB66322.1
genomic	AL590083.8	CAD18851.1
genomic	AY301274.1	AAP58404.1
genomic	CH471104.2	EAW98596.1
genomic	U66578.1	AAC51301.1
genomic	U90323.1	AAB62087.1
mRNA	AA424772.1	None
mRNA	AK314134.1	BAG36824.1
mRNA	BC069996.1	AAH69996.1
mRNA	BC074722.2	AAH74722.1
mRNA	BC095538.1	AAH95538.1
mRNA	BM973092.1	None
mRNA	BX100826.1	None
mRNA	DA735126.1	None
mRNA	U90322.1	AAB62088.1