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KLK9 kallikrein related peptidase 9 [ Homo sapiens (human) ]

Gene ID: 284366, updated on 26-May-2016
Official Symbol
KLK9provided by HGNC
Official Full Name
kallikrein related peptidase 9provided by HGNC
Primary source
HGNC:HGNC:6370
See related
Ensembl:ENSG00000213022 Ensembl:ENSG00000269741 HPRD:05692; MIM:605504; Vega:OTTHUMG00000183088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLKL3; KLK-L3
Summary
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]
Annotation information
Note: The KLK9 gene is immediately upstream of the KLK8 gene. There are a few transcripts (DQ267419, DQ267420, AY566267, and BC040887) that span the gap between these two genes and which suggest the presence of a bicistronic transcript. However, there is no published support for that, so they will continue to be represented as separate genes. [13 Feb 2013]
Orthologs
Location:
19q13.41
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (51002513..51009634, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51505769..51512890, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 7 Neighboring gene kallikrein related peptidase 8 Neighboring gene kallikrein related peptidase 10 Neighboring gene kallikrein related peptidase 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: KLK8

Homology

Clone Names

  • MGC50513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kallikrein-9
Names
kallikrein-like protein 3
kallikrein-related peptidase 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027832.1 RefSeqGene

    Range
    5001..12122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012315.1NP_036447.1  kallikrein-9 precursor

    See identical proteins and their annotated locations for NP_036447.1

    Status: REVIEWED

    Source sequence(s)
    AF135026
    Consensus CDS
    CCDS12816.1
    UniProtKB/Swiss-Prot
    Q9UKQ9
    UniProtKB/TrEMBL
    Q2XQG6
    Related
    ENSP00000469417, OTTHUMP00000270942, ENST00000594211, OTTHUMT00000465226
    Conserved Domains (2) summary
    smart00020
    Location:22244
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    51002513..51009634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    51507767..51514843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)