LAMA1 laminin, alpha 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: LAMA1provided by HGNC
Official Full Name: laminin, alpha 1provided by HGNC
Primary source: HGNC:6481
See related: Ensembl:ENSG00000101680; HPRD:01033; MIM:150320; Vega:OTTHUMG00000133478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAMA; S-LAM-alpha

Help top of page

Genomic context

Location :: 18p11.3

Sequence :: Chromosome: 18; NC_000018.9 (6941743..7117813, complement)

See LAMA1 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Laminin-alpha1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-kappaB transcription factors but also has adverse effects.
Title: Laminin-α1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-κB transcription factors but also has adverse effects.
The polymorphism of SNP rs2089760, located in the promoter region of LAMA1, may be associated with high myopia in the Chinese population.
Title: The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia.
c-Jun/AP-1 activity mediated by JNK, PI3K/Akt and ERK pathways is required for laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells.
Title: c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways.
Abnormal distribution of laminin alpha1 and laminin alpha5 in glomerular basement membrane is correlated with GBM thickening and splitting in human Alport's syndrome.
Title: [Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome].
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin.
Title: Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin.
Promoter -1030C/T polymorphism of LMNA is a possible genetic predisposition to arterial stiffness in the Japanese population
Title: A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study).
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

Submit: New GeneRIF Correction See all (22)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population.

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P25391	P22303	ACHE	HPRD	PubMed
P25391	P02743	APCS	HPRD	PubMed
P25391	P05067	APP	HPRD	PubMed
P25391	P01024	C3	HPRD	PubMed
P25391	Q02388	COL7A1	HPRD	PubMed
P25391	Q14118	DAG1	HPRD	PubMed
P25391	P98095	FBLN2	HPRD	PubMed
P25391	P98160	HSPG2	HPRD	PubMed
P25391	P56199	ITGA1	HPRD	PubMed
P25391	P17301	ITGA2	HPRD	PubMed
P25391	P05556	ITGB1	HPRD	PubMed
P25391	Q16819	MEP1A	HPRD	PubMed
P25391	P14543	NID1	HPRD	PubMed
P25391	P21589	NT5E	HPRD	PubMed
P25391	P00750	PLAT	HPRD	PubMed
P25391	P00747	PLG	HPRD	PubMed
P25391	P02735	SAA1	HPRD	PubMed
P25391	Serum Amyloid A1	SAA1	HPRD	PubMed
P25391	Q8IU80	TMPRSS6	HPRD	PubMed
BioGRID:129792	BioGRID:108493	FBLN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:109571	HSPG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:109879	ITGA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:109880	ITGA2	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:109894	ITGB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:110387	MEP1A	BioGRID	PubMed	Biochemical Activity
BioGRID:129792	BioGRID:111343	PLAT	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:111356	PLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:129792	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
extracellular matrix structural constituent	ISS Inferred from Sequence or Structural Similarity more info
glycosphingolipid binding	IEA Inferred from Electronic Annotation more info
receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
axon guidance	TAS Traceable Author Statement more info
branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
epithelial tube branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
morphogenesis of an epithelial sheet	IEA Inferred from Electronic Annotation more info
neuron projection development	IEA Inferred from Electronic Annotation more info
regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
regulation of cell migration	IEA Inferred from Electronic Annotation more info
regulation of embryonic development	IEA Inferred from Electronic Annotation more info
retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
retinal blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
tissue development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basement membrane	IDA Inferred from Direct Assay more info	PubMed
cell-cell junction	IEA Inferred from Electronic Annotation more info
colocalizes_with extracellular matrix	TAS Traceable Author Statement more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
laminin-1 complex	IDA Inferred from Direct Assay more info	PubMed
laminin-1 complex	IPI Inferred from Physical Interaction more info	PubMed
laminin-3 complex	IPI Inferred from Physical Interaction more info	PubMed
proteinaceous extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: laminin subunit alpha-1

Names: laminin subunit alpha-1; S-LAM alpha; laminin A chain; S-laminin subunit alpha; laminin-3 subunit alpha

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005559.3 → NP_005550.2 laminin subunit alpha-1 precursor

Status: VALIDATED

Source sequence(s)

AP002409, AP005062, AP005210

Consensus CDS

CCDS32787.1

UniProtKB/Swiss-Prot

P25391

Related

ENSP00000374309, OTTHUMP00000164711, ENST00000389658, OTTHUMT00000257369

Conserved Domains (7) summary

cd00055
Location:901 – 949
Blast Score: 152

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2307 – 2463
Blast Score: 332

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1567 – 1817
Blast Score: 741

Laminin_I; Laminin Domain I

cl02548
Location:1218 – 1360
Blast Score: 515

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:902 – 948
Blast Score: 170

Laminin_EGF; Laminin EGF-like (Domains III and V)

pfam06009
Location:2011 – 2145
Blast Score: 467

Laminin_II; Laminin Domain II

cl02806
Location:22 – 268
Blast Score: 958

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

6941743..7117813, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

6905118..7080842, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP002409.3 (67037..180565)	None
genomic	AP005062.2 (7984..68622)	None
genomic	AP005210.2 (178834..180736)	None
genomic	CH471113.2	EAX01628.1
		EAX01629.1
		EAX01630.1
		EAX01631.1
mRNA	AF351616.1	AAN76516.1
mRNA	AK091949.1	BAG52448.1
mRNA	AK093376.1	BAG52700.1
mRNA	BC016997.1	None
mRNA	BC032758.1	None
mRNA	BC039051.1	AAH39051.1
mRNA	BC062318.1	AAH62318.1
mRNA	BC107693.1	None
mRNA	BC144590.1	None
mRNA	X58531.1	CAA41418.1
other-genetic	BC172449.1	AAI72449.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P25391.2	GenPept	UniProtKB/Swiss-Prot:P25391
Q6P6D3	GenPept	UniProtKB/TrEMBL:Q6P6D3
Q7Z5W6	GenPept	UniProtKB/TrEMBL:Q7Z5W6
Q8IXG5	GenPept	UniProtKB/TrEMBL:Q8IXG5