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GSDMA gasdermin A [ Homo sapiens (human) ]

Gene ID: 284110, updated on 8-May-2016
Official Symbol
GSDMAprovided by HGNC
Official Full Name
gasdermin Aprovided by HGNC
Primary source
HGNC:HGNC:13311
See related
Ensembl:ENSG00000167914 HPRD:17081; MIM:611218; Vega:OTTHUMG00000179522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSDM; FKSG9; GSDM1
Orthologs
Location:
17q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (39962973..39977880)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38119226..38134019)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ORMDL sphingolipid biosynthesis regulator 3 Neighboring gene leucine rich repeat containing 3C Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene uncharacterized LOC102724103 Neighboring gene colony stimulating factor 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
NHGRI GWA Catalog
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
A large-scale, consortium-based genomewide association study of asthma.
NHGRI GWA Catalog
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
NHGRI GWA Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Multiple loci are associated with white blood cell phenotypes.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39120, MGC129596

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
gasdermin-A
Names
gasdermin 1
gasdermin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178171.4NP_835465.2  gasdermin-A

    See identical proteins and their annotated locations for NP_835465.2

    Status: VALIDATED

    Source sequence(s)
    AA826386, AC090844, AF307953, AK096439
    Consensus CDS
    CCDS45669.1
    UniProtKB/Swiss-Prot
    Q96QA5
    Related
    ENSP00000301659, OTTHUMP00000261713, ENST00000301659, OTTHUMT00000446847
    Conserved Domains (1) summary
    pfam04598
    Location:3420
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    39962973..39977880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721832.2XP_006721895.1  

    See identical proteins and their annotated locations for XP_006721895.1

    UniProtKB/Swiss-Prot
    Q96QA5
    Conserved Domains (1) summary
    pfam04598
    Location:3420
    Gasdermin; Gasdermin family
  2. XM_011524651.1XP_011522953.1  

    Conserved Domains (1) summary
    pfam04598
    Location:1278
    Gasdermin; Gasdermin family

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    38354903..38369695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)