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GPR15 G protein-coupled receptor 15 [ Homo sapiens (human) ]

Gene ID: 2838, updated on 26-May-2016
Official Symbol
GPR15provided by HGNC
Official Full Name
G protein-coupled receptor 15provided by HGNC
Primary source
See related
Ensembl:ENSG00000154165 HPRD:03102; MIM:601166; Vega:OTTHUMG00000160017
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
Exon count:
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (98531899..98533150)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98250743..98251994)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374001 Neighboring gene claudin domain containing 1 Neighboring gene ribosomal protein L38 pseudogene 4 Neighboring gene coproporphyrinogen oxidase Neighboring gene ribosomal protein L19 pseudogene 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 ZP6248 T/F virus efficiently uses an alternative coreceptor GPR15 to establish clinical infection, and gp120 G306A, V307A, E314A, K315A, V316A, Y317A, F318A and S322A mutations significantly reduce or abolish the replication capacity in GPR15+ cells PubMed
env HIV gp120-induced calcium signaling, microtubule loss, and physiological changes on HT-29 cells are inhibited by anti-Bob/GPR15 neutralizing antibodies, suggesting that gp120-induced Bob/GRP15 activation is a plausible cause of HIV enteropathy PubMed

Go to the HIV-1, Human Interaction Database

  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description



Clone Names

  • MGC126828, MGC126830

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
T cell migration IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
plasma membrane TAS
Traceable Author Statement
more info
Preferred Names
G-protein coupled receptor 15
brother of Bonzo

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005290.3NP_005281.1  G-protein coupled receptor 15

    See identical proteins and their annotated locations for NP_005281.1

    Status: REVIEWED

    Source sequence(s)
    AA687817, AC021660, AK313375, BC101779
    Consensus CDS
    B2R8H6, B6V9G9
    ENSP00000284311, OTTHUMP00000217372, ENST00000284311, OTTHUMT00000358907
    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly


  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018914.2 Alternate CHM1_1.1

    GenBank, FASTA, Sequence Viewer (Graphics)