ANG angiogenin, ribonuclease, RNase A family, 5 [Homo sapiens] - Gene

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Summary

Official Symbol: ANGprovided by HGNC
Official Full Name: angiogenin, ribonuclease, RNase A family, 5provided by HGNC
Primary source: HGNC:483
See related: Ensembl:ENSG00000214274; HPRD:00105; MIM:105850; Vega:OTTHUMG00000029576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALS9; HEL168; RNASE4; RNASE5; MGC22466; MGC71966
Summary: The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 14q11.1-q11.2

Sequence :: Chromosome: 14; NC_000014.8 (21152336..21162345)

See ANG in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify novel variants in SOD1, ANG, TARDBP and FUS, and expand the FUS-associated clinicopathologic phenotype of amyotrophic lateral sclerosis.
Title: SOD1, ANG, TARDBP and FUS mutations in amyotrophic lateral sclerosis: a United States clinical testing lab experience.
At physiological pH, the prevailing complex species formed by the peptide encompassing the protein sequence 4-17 is [CuHL], in which the metal ion is bound to two imidazole and two deprotonated amide nitrogen atoms.
Title: Probing the copper(II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein.
Data suggest that umbilical cord blood-derived endothelial progenitor cells are confined to CD14-/CD34+ subpopulation and angiogenin1 released from CD14+ subpopulation may be an important factor promoting the EPC colony formation.
Title: CD14-/CD34+ is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation.
Amniotic fluid angiogenin levels are decreased in pregnancies with fetal trisomy 21.
Title: Amniotic fluid angiogenin levels are decreased in pregnancies with fetal trisomy 21.
The data from this multicenter study demonstrate that there is a strong association between Parkinson disease, amyotrophic lateral sclerosis, and Angiogenin(ag) variants. AG is a genetic link between amyotrophic lateral sclerosis and Parkinson disease .
Title: Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis.
Patients with poorly controlled type 2 diabetes (A1C >7%) have lower angiogenin levels than patients with well-controlled diabetes.
Title: Glycemic control influences serum angiogenin concentrations in patients with type 2 diabetes.
This report confirms that clinical course of SOD1-related ALS may be modulated by ANG.
Title: SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variant.
increased expression in nasal polyps
Title: Increased expression of angiogenin in nasal polyps.
serum angiogenin at diagnosis may have a role in failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma
Title: High serum angiogenin at diagnosis predicts for failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma.
VEGF may regulate Ang-2 expression and promote angiogenesis and acute leukemia development.
Title: [Expression of angiogenin-2 and VEGF in acute leukemia and its significance].

Submit: New GeneRIF Correction See all (74)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Amyotrophic lateral sclerosis 9

MIM: 611895

Amyotrophic lateral sclerosis, susceptibility to

MIM: 105400

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001136.1	CAB61269.1	ACTN2	BIND	PubMed	ANG interacts with ACTN2. This interaction was modeled on a demonstrated interaction between ANG from unspecified species and human ACTN2.
P03950	P68032	ACTC1	HPRD	PubMed
P03950	P35609	ACTN2	HPRD	PubMed
P03950	Q15904	ATP6AP1	HPRD	PubMed
P03950	P60484	PTEN	HPRD	PubMed
P03950	P13489	RNH1	HPRD	PubMed
P03950	P13385	TDGF1	HPRD	PubMed
P03950	P32971	TNFSF8	HPRD	PubMed
BioGRID:106780	BioGRID:107019	ATP6AP1	BioGRID	PubMed	Two-hybrid
BioGRID:106780	BioGRID:111700	PTEN	BioGRID	PubMed	Two-hybrid
BioGRID:106780	BioGRID:111977	RNH1	BioGRID	PubMed	Co-crystal Structure
BioGRID:106780	BioGRID:112856	TDGF1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IC Inferred by Curator more info	PubMed
actin binding	IDA Inferred from Direct Assay more info	PubMed
copper ion binding	IDA Inferred from Direct Assay more info	PubMed
endonuclease activity	TAS Traceable Author Statement more info	PubMed
heparin binding	IDA Inferred from Direct Assay more info	PubMed
hydrolase activity	IEA Inferred from Electronic Annotation more info
pancreatic ribonuclease activity	IEA Inferred from Electronic Annotation more info
peptide binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
rRNA binding	TAS Traceable Author Statement more info	PubMed
receptor binding	IDA Inferred from Direct Assay more info	PubMed
ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
activation of phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
activation of phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
activation of protein kinase B activity	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	IDA Inferred from Direct Assay more info	PubMed
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	TAS Traceable Author Statement more info	PubMed
cell communication	NAS Non-traceable Author Statement more info	PubMed
cell death	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
diacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
homeostatic process	NAS Non-traceable Author Statement more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of translation	IEA Inferred from Electronic Annotation more info
oocyte maturation	NAS Non-traceable Author Statement more info	PubMed
ovarian follicle development	NAS Non-traceable Author Statement more info	PubMed
placenta development	NAS Non-traceable Author Statement more info	PubMed
positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
rRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
response to hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
angiogenin-PRI complex	IPI Inferred from Physical Interaction more info	PubMed
basal lamina	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
growth cone	ISS Inferred from Sequence or Structural Similarity more info
neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
nucleolus	ISS Inferred from Sequence or Structural Similarity more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: angiogenin

Names: angiogenin; RNase 5; ribonuclease 5; epididymis luminal protein 168

NP_001091046.1

EC 3.1.27.-

NP_001136.1

EC 3.1.27.-

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008717.1 RefSeqGene

Range

5001..15010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001097577.2 → NP_001091046.1 angiogenin precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950

Related

ENSP00000381077, OTTHUMP00000164020, ENST00000397990, OTTHUMT00000073732

Conserved Domains (1) summary

cd06265
Location:28 – 141
Blast Score: 368

RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have been ...
NM_001145.4 → NP_001136.1 angiogenin precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950

Related

ENSP00000336762, OTTHUMP00000164019, ENST00000336811, OTTHUMT00000073731

Conserved Domains (1) summary

cd06265
Location:28 – 141
Blast Score: 368

RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have been ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

21152336..21162345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

1273259..1283264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF449647.1	AAL67710.1
genomic	AF449648.1	AAL67711.1
genomic	AF449649.1	AAL67712.1
genomic	AF449650.1	AAL67713.1
genomic	AF449651.1	AAL67714.1
genomic	AL163636.7 (116264..126273)	None
genomic	CH471078.2	EAW66450.1
		EAW66451.1
genomic	M11567.1	AAA51678.1
mRNA	AK313989.1	BAG36701.1
mRNA	AV646929.1	None
mRNA	BC020704.1	AAH20704.1
mRNA	BC054880.1	AAH54880.1
mRNA	BC062698.1	AAH62698.1
mRNA	BQ773604.1	None
mRNA	CB157060.1	None
mRNA	CB963791.1	None
mRNA	CR407633.1	CAG28561.1
mRNA	FJ236304.1	ACI45236.1
other-genetic	HQ447651.1	ADQ32136.1