ADRBK1 adrenergic, beta, receptor kinase 1 [Bos taurus] - Gene

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Summary

Gene symbol: ADRBK1
Gene description: adrenergic, beta, receptor kinase 1
Locus tag: BOS_24950
See related: Ensembl:ENSBTAG00000005832
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GRK2
Annotation information: Annotation category: partial on reference assembly

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Genomic context

Location :: chromosome: 29

Sequence :: Chromosome: 29; AC_000186.1 (45844926..45852845)

See ADRBK1 in MapViewer

Chromosome 29 - AC_000186.1 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.
Title: Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
Resultrs suggest that activated platelet-derived growth factor receptor-beta (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.
Title: The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.
Title: The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.
GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor
Title: Chemical genetic engineering of G protein-coupled receptor kinase 2.
G protein-coupled receptor kinase 2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened
Title: Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq, Gbetagamma
Title: Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.
epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2.
Title: The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).
Title: Involvement of intramolecular interactions in the regulation of G protein-coupled receptor kinase 2.
G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}
Title: G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.
determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.
Title: Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:159836	BioGRID:112506	SNCA	BioGRID	PubMed	Biochemical Activity
BioGRID:159836	BioGRID:112504	SNCB	BioGRID	PubMed	Biochemical Activity
BioGRID:159836	BioGRID:112507	SNCG	BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
Edg-2 lysophosphatidic acid receptor binding	ISS Inferred from Sequence or Structural Similarity more info
G-protein coupled receptor kinase activity	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled receptor kinase activity	ISS Inferred from Sequence or Structural Similarity more info
alpha-2A adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
beta-adrenergic receptor kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
G-protein coupled acetylcholine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled receptor internalization	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
desensitization of G-protein coupled receptor protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
desensitization of G-protein coupled receptor protein signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
heart development	ISS Inferred from Sequence or Structural Similarity more info
intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of the force of heart contraction by chemical signal	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of the force of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
termination of G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
intracellular	IMP Inferred from Mutant Phenotype more info	PubMed
membrane	IC Inferred by Curator more info	PubMed
membrane	IDA Inferred from Direct Assay more info	PubMed
membrane	ISS Inferred from Sequence or Structural Similarity more info
membrane fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: beta-adrenergic receptor kinase 1

Names: beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein-coupled receptor kinase 2

NP_777135.1

EC 2.7.11.15

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174710.2 → NP_777135.1 beta-adrenergic receptor kinase 1

Status: PROVISIONAL

Source sequence(s)

M34019

UniProtKB/Swiss-Prot

P21146

Related

ENSBTAP00000050806, ENSBTAT00000055962

Conserved Domains (5) summary

cd05606
Location:196 – 473
Blast Score: 1563

STKc_beta_ARK; Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase

cd01240
Location:557 – 669
Blast Score: 483

PH_beta-ARK; Beta adrenergic receptor kinase 1(beta ARK1)(GRK2) pleckstrin homology (PH) domain

cd08747
Location:30 – 186
Blast Score: 811

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

pfam00069
Location:191 – 453
Blast Score: 719

Pkinase; Protein kinase domain

cl11395
Location:454 – 520
Blast Score: 105

Pkinase_C; Protein kinase C terminal domain