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SLC6A4 solute carrier family 6 member 4 [ Bos taurus (cattle) ]

Gene ID: 282365, updated on 5-Mar-2024

Summary

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Official Symbol
SLC6A4provided by VGNC
Official Full Name
solute carrier family 6 member 4provided by VGNC
Primary source
VGNC:VGNC:49971
See related
Ensembl:ENSBTAG00000019349
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SERT
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (21290410..21323269, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene microRNA mir-423 Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene uncharacterized LOC101904701 Neighboring gene bleomycin hydrolase Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene small nucleolar RNA SNORA57

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of lactation and acceleration of involution in the bovine mammary gland by a selective serotonin reuptake inhibitor. Hernandez LL, et al. J Endocrinol, 2011 Apr. PMID 21307120
  2. Molecular cloning, expression and characterization of a bovine serotonin transporter. Mortensen OV, et al. Brain Res Mol Brain Res, 1999 Jul 23. PMID 10407194
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper contains kinetics data of serotonin receptor binding.
    Title: Molecular cloning, expression and characterization of a bovine serotonin transporter.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serotonin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serotonin:sodium:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in serotonin uptake IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium-dependent serotonin transporter
Names
5HT transporter
5HTT
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174609.2 → NP_777034.1  sodium-dependent serotonin transporter

    See identical proteins and their annotated locations for NP_777034.1

    Status: PROVISIONAL

    Source sequence(s)
    AF119122
    UniProtKB/Swiss-Prot
    Q9XT49
    Related
    ENSBTAP00000067324.1, ENSBTAT00000082189.1
    Conserved Domains (2) summary
    cd11513
    Location:79 → 615
    SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
    pfam03491
    Location:24 → 64
    5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21290410..21323269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979631.2 → XP_024835399.1  sodium-dependent serotonin transporter isoform X2

    UniProtKB/Swiss-Prot
    Q9XT49
    Conserved Domains (2) summary
    cd11513
    Location:79 → 615
    SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
    pfam03491
    Location:24 → 64
    5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus

  2. XM_024979632.2 → XP_024835400.1  sodium-dependent serotonin transporter isoform X2

    UniProtKB/Swiss-Prot
    Q9XT49
    Conserved Domains (2) summary
    cd11513
    Location:79 → 615
    SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
    pfam03491
    Location:24 → 64
    5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus

  3. XM_059877730.1 → XP_059733713.1  sodium-dependent serotonin transporter isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XT49.1 GenPept UniProtKB/Swiss-Prot:Q9XT49

Gene LinkOut

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