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    SLCO1B3 solute carrier organic anion transporter family, member 1B3 [ Homo sapiens ]

    Gene ID: 28234, updated on 19-May-2012
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    Summary

    Official Symbol
    SLCO1B3provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family, member 1B3provided by HGNC
    Primary source
    HGNC:10961
    See related
    Ensembl:ENSG00000111700; Ensembl:ENSG00000257046; HPRD:12021; MIM:605495; Vega:OTTHUMG00000169011; Vega:OTTHUMG00000169018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13
    Summary
    This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
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    Genomic context

    Location :
    12p12
    Sequence :
    Chromosome: 12; NC_000012.11 (20963638..21069658)
    See SLCO1B3 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A, cGMP-inhibited Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene Neighboring gene solute carrier organic anion transporter family, member 1C1 Neighboring gene solute carrier organic anion transporter family, member 1B7 (non-functional) Neighboring gene solute carrier organic anion transporter family, member 1B1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Nagai M, et al. Biochem Biophys Res Commun, 2012 Feb 24. PMID 22326869.
    2. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. van de Steeg E, et al. J Clin Invest, 2012 Feb 1. PMID 22232210.
    3. The association of the UGT1A8, SLCO1B3 and ABCC2/ABCG2 genetic polymorphisms with the pharmacokinetics of mycophenolic acid and its phenolic glucuronide metabolite in Chinese individuals. Geng F, et al. Clin Chim Acta, 2012 Apr 11. PMID 22227166.
    4. Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters. Takanohashi T, et al. J Pharm Pharmacol, 2012 Feb. PMID 22221095.
    5. Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy. Wang H, et al. Arch Gynecol Obstet, 2012 Jun. PMID 22203093.

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Digoxin inhibited the uptake of probe substrates of OATP1B1 (IC(50) of 47 muM), OATP1B3 (IC(50) > 8.1 muM), and OATP2B1 (IC(50) > 300 muM), but not OATP1A2 in transfected cell lines.
      Title: Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.
    2. Thirty-six variations of OATP1B3 were identified in the Korean population, consisting of nine variations in the 5'-upstream region, ten in the exon regions, and seventeen in the intron regions.
      Title: Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population.
    3. Data show that Rotor syndrome was linked to mutations predicted to cause complete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.
      Title: Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
    4. Isoform specific mRNA quantification showed that the Ct-OATP1B3 mRNA level was strikingly higher than that of Lt-OATP1B3 mRNA in human cancer tissues.
      Title: Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells.
    5. Data suggest OATP1B1 and OATP1B3 are high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues (or when expressed as recombinant proteins in Xenopus laevis oocytes).
      Title: Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.
    6. immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis
      Title: The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging.
    7. This study demonstrated that plated primary human hepatocytes are useful as an in vitro model for OATP1B1/1B3-mediated uptake studies, but the culture time may substantially change the uptake kinetics.
      Title: OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.
    8. SLCO1B3 expression, rather than CTNNB1 mutation, is the critical determinant of intratumoral cholestasis.
      Title: Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma.
    9. we studied a series of hepatocellular carcinomas from livers that underwent liver transplantation and correlated the expression of OATP 1B1/1B3 with morphological features
      Title: OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation.
    10. Genetic variants of SLCO1B3 may function as pharmacogenomic determinants of resistance to androgen deprivation therapy in prostate cancer.
      Title: SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.
    Submit: New GeneRIF Correction See all (49)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Hyperbilirubinemia, Rotor type, digenic

    Many sequence variants affecting diversity of adult human height.

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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
      Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Recycling of bile acids and salts, organism-specific biosystem (from REACTOME)
      Recycling of bile acids and salts, organism-specific biosystemOf the 20-40 grams of bile salts released daily by the liver, all but approximately 0.5 grams are reabsorbed from the intestine, returned to the liver, and re-used. This recycling involves a series o...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of organic anions, organism-specific biosystem (from REACTOME)
      Transport of organic anions, organism-specific biosystemOrganic anion transporting polypeptides (OATPs) are membrane transport proteins that mediate the sodium-independent transport of a wide range of amphipathic organic compounds including bile salts, st...
    • Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem (from REACTOME)
      Transport of vitamins, nucleosides, and related molecules, organism-specific biosystemThis pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
    		  
    bile acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    organic anion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1B3
    Names
    solute carrier organic anion transporter family member 1B3
    organic anion transporter 8
    organic anion transporter LST-3c
    organic anion-transporting polypeptide 8
    liver-specific organic anion transporter 2
    liver-specific organic anion transporter 3TM13
    solute carrier family 21 (organic anion transporter), member 8
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032071.1 RefSeqGene

      Range
      5001..111208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019844.3 → NP_062818.1  solute carrier organic anion transporter family member 1B3

      Status: REVIEWED

      Source sequence(s)
      AC011604, AJ251506, AK055874, BG567966, BM968322
      Consensus CDS
      CCDS8684.1
      UniProtKB/TrEMBL
      B3KP78
      UniProtKB/Swiss-Prot
      Q9NPD5
      Related
      ENSP00000261196, ENST00000261196
      Conserved Domains (3) summary
      cd01330
      Location:455 – 508
      Blast Score: 227
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      cd06174
      Location:31 – 121
      Blast Score: 97
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam03137
      Location:27 – 622
      Blast Score: 1786
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      20963638..21069658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      20736680..20842657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011604.10 (127160..127443) None
    genomic AJ400763.1 CAB97008.1
    genomic AJ400764.1 None
    genomic AJ400765.1 None
    genomic AJ400766.1 None
    genomic AJ400767.1 None
    genomic AJ400768.1 None
    genomic AJ400769.1 None
    genomic AJ400770.1 None
    genomic AJ400771.1 None
    genomic AJ400772.1 None
    genomic AJ400773.1 None
    genomic AJ400774.1 None
    genomic AJ400775.1 None
    genomic AJ400776.1 None
    genomic CH471094.1 EAW96413.1
      EAW96414.1
      EAW96415.1
    mRNA AF187815.1 AAG43445.1
    mRNA AJ251506.1 CAB96997.1
    mRNA AK055874.1 BAG51590.1
    mRNA AY342017.1 AAQ19672.1
    mRNA BC022843.1 AAH22843.1
    mRNA BC058006.1 None
    mRNA BC070264.1 AAH70264.1
    mRNA BC105597.1 AAI05598.1
    mRNA BG567966.1 None
    mRNA BM968322.1 None
    other-genetic BC141525.1 AAI41526.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGL9 GenPept UniProtKB/TrEMBL:Q0VGL9
    Q5JAR4 GenPept UniProtKB/TrEMBL:Q5JAR4
    Q6NSD0 GenPept UniProtKB/TrEMBL:Q6NSD0
    Q7Z454 GenPept UniProtKB/TrEMBL:Q7Z454
    Q9NPD5.1 GenPept UniProtKB/Swiss-Prot:Q9NPD5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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