RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 [Bos taurus] - Gene

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Summary

Symbol: RABGEF1
Full Name: RAB guanine nucleotide exchange factor (GEF) 1
Primary source: BGD:BT26180
Locus tag: BOS_22847
See related: Ensembl:ENSBTAG00000003842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: RABEX5; MGC128930
Annotation information: Annotation category: partial on reference assembly

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Genomic context

Location :: chromosome: 25

Sequence :: Chromosome: 25; AC_000182.1 (28509106..28532974)

See RABGEF1 in MapViewer

Chromosome 25 - AC_000182.1 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
Title: The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.
Receptor recycling is mediated by AP-1/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5.
Title: In vitro formation of recycling vesicles from endosomes requires adaptor protein-1/clathrin and is regulated by rab4 and the connector rabaptin-5.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor activity and of Rab5.
Title: Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo.
Title: Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Title: Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:159596	BioGRID:114583	RABEP1	BioGRID	PubMed	Two-hybrid
BioGRID:159596	BioGRID:160681	UBC	BioGRID	PubMed	Co-crystal Structure
BioGRID:159596	BioGRID:113164	UBC	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
endocytosis	IEA Inferred from Electronic Annotation more info
protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
early endosome	IEA Inferred from Electronic Annotation more info
recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: rab5 GDP/GTP exchange factor

Names: rab5 GDP/GTP exchange factor; rabex-5; Rab5 guanine nucleotide exchange factor Rabex-5

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174591.1 → NP_777016.1 rab5 GDP/GTP exchange factor

Status: PROVISIONAL

Source sequence(s)

AJ001119

UniProtKB/Swiss-Prot

O18973

Related

ENSBTAP00000005011, ENSBTAT00000005011

Conserved Domains (2) summary

cl02496
Location:271 – 371
Blast Score: 312

VPS9; Vacuolar sorting protein 9 (VPS9) domain

cl11604
Location:16 – 40
Blast Score: 129

zf-A20; A20-like zinc finger