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POLR2A RNA polymerase II subunit A [ Bos taurus (cattle) ]

Gene ID: 282312, updated on 20-Apr-2024

Summary

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Official Symbol
POLR2Aprovided by VGNC
Official Full Name
RNA polymerase II subunit Aprovided by VGNC
Primary source
VGNC:VGNC:33135
See related
BGD:BT12253; Ensembl:ENSBTAG00000046765
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (27151259..27171770)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene solute carrier family 35 member G6 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12 Neighboring gene uncharacterized LOC112442633 Neighboring gene uncharacterized LOC112442634

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Krum SA, et al. Oncogene, 2003 Sep 4. PMID 12955082
  2. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription. Schlegel BP, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10725406, Free PMC Article
  3. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Garber ME, et al. Mol Cell Biol, 2000 Sep. PMID 10958691, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA-directed RNA polymerase II subunit RPB1
Names
3'-5' exoribonuclease
RNA-directed RNA polymerase II subunit RPB1
polymerase (RNA) II (DNA directed) polypeptide A (220kD)
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
NP_001193242.1
XP_024835398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206313.2 → NP_001193242.1  DNA-directed RNA polymerase II subunit RPB1

    See identical proteins and their annotated locations for NP_001193242.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000019
    UniProtKB/Swiss-Prot
    G3MZY8
    Related
    ENSBTAP00000065848.1, ENSBTAT00000069267.2
    Conserved Domains (5) summary
    cd02584
    Location:1058 → 1476
    RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
    smart01104
    Location:1491 → 1610
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    cd02733
    Location:19 → 876
    RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
    pfam05109
    Location:1854 → 1959
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam04992
    Location:896 → 1079
    RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27151259..27171770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979630.2 → XP_024835398.1  DNA-directed RNA polymerase II subunit RPB1 isoform X1

    UniProtKB/Swiss-Prot
    G3MZY8
    Conserved Domains (5) summary
    cd02584
    Location:1058 → 1476
    RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
    smart01104
    Location:1491 → 1610
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    cd02733
    Location:19 → 876
    RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
    pfam05109
    Location:1854 → 1959
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam04992
    Location:896 → 1079
    RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3MZY8.2 GenPept UniProtKB/Swiss-Prot:G3MZY8

Gene LinkOut

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