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    PPP2R3B protein phosphatase 2, regulatory subunit B'', beta [ Homo sapiens ]

    Gene ID: 28227, updated on 20-May-2012
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    Summary

    Official Symbol
    PPP2R3Bprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', betaprovided by HGNC
    Primary source
    HGNC:13417
    Locus tag
    LL0YNC03-56G10.1
    See related
    Ensembl:ENSG00000167393; HPRD:02276; MIM:300339; Vega:OTTHUMG00000021052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR48; NYREN8; PPP2R3L; PPP2R3LY; FLJ60425
    Summary
    Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
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    Genomic context

    Location :
    Xp22.33; Yp11.3
    Sequence :
    Chromosome: Y; NC_000024.9 (244668..297690, complement)
    Chromosome: X; NC_000023.10 (294668..347690, complement)
    See PPP2R3B in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene PPP2R3B antisense RNA 1 (non-protein coding) Neighboring gene short stature homeobox Neighboring gene ribosomal protein L14 pseudogene

    Chromosome Y - NC_000024.9Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene PPP2R3B antisense RNA 1 (non-protein coding) Neighboring gene short stature homeobox Neighboring gene 60S ribosomal protein L14-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault M, et al. Mol Cell Proteomics, 2009 Jan. PMID 18782753.
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. Stevens I, et al. Eur J Biochem, 2003 Jan. PMID 12605688.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y5P8 Q99741 CDC6    HPRD  PubMed  
    Q9Y5P8 P30153 PPP2R1A    HPRD  PubMed  
    BioGRID:118179 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:118179 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:118179 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:118179 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:118179 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystem (from REACTOME)
      Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystem
      Inhibition of replication initiation of damaged DNA by RB1/E2F1
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    protein phosphatase type 2A regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
    Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
    NY-REN-8 antigen
    PP2A, subunit B, PR48 isoform
    protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
    serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013257.1 RefSeqGene

      Range
      4938..57960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013239.4 → NP_037371.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

      Status: REVIEWED

      Source sequence(s)
      AL954664, BK000521, BM666129, BM715684, DA061573
      Consensus CDS
      CCDS14104.1
      UniProtKB/Swiss-Prot
      Q9Y5P8
      Related
      ENSP00000375080, OTTHUMP00000022818, ENST00000390665, OTTHUMT00000055577
      Conserved Domains (1) summary
      pfam13499
      Location:370 – 417
      Blast Score: 95
      EF_hand_5; EF-hand domain pair

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      294668..347690, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. NW_001841157.1 Alternate HuRef

      Range
      1543591..1595281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. NW_001841974.1 Alternate HuRef

      Range
      72..1579, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199326.1: Suppressed sequence

      Description
      NM_199326.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF215839.1 None
    genomic AF215840.1 None
    genomic AL732314.18 (2000..4097) None
    genomic AL954664.18 (8189..25614) None
    genomic BX000476.5 CAI41975.1
    genomic CH471225.1 EAW66818.1
      EAW66819.1
    mRNA AB209137.1 BAD92374.1
    mRNA AF135016.1 AAD38515.1
    mRNA AF155098.1 AAD42864.1
    mRNA AI248426.1 None
    mRNA AK293506.1 BAG56990.1
    mRNA AL157501.1 CAB75680.1
    mRNA BC009032.1 AAH09032.1
    mRNA BC011180.1 AAH11180.2
    mRNA BC063429.1 AAH63429.1
    mRNA BF530463.1 None
    mRNA BI828434.1 None
    mRNA BK000521.1 DAA00385.1
    mRNA BM666129.1 None
    mRNA BM676246.1 None
    mRNA BM715684.1 None
    mRNA BU845905.1 None
    mRNA CB218994.1 None
    mRNA DA061573.1 None
    other-genetic HQ447089.1 ADQ31576.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59GH2 GenPept UniProtKB/TrEMBL:Q59GH2
    Q96FD8 GenPept UniProtKB/TrEMBL:Q96FD8
    Q9NSQ1 GenPept UniProtKB/TrEMBL:Q9NSQ1
    Q9UHL2 GenPept UniProtKB/TrEMBL:Q9UHL2
    Q9Y5P8.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P8
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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      Supplemental Content

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