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SCN5A sodium voltage-gated channel alpha subunit 5 [ Bos taurus (cattle) ]

Gene ID: 282061, updated on 3-Apr-2024

Summary

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Official Symbol
SCN5Aprovided by VGNC
Official Full Name
sodium voltage-gated channel alpha subunit 5provided by VGNC
Primary source
VGNC:VGNC:34352
See related
Ensembl:ENSBTAG00000009155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (11975423..12080448, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene activin A receptor type 2B Neighboring gene exo/endonuclease G Neighboring gene U6 spliceosomal RNA Neighboring gene sodium voltage-gated channel alpha subunit 10 Neighboring gene sodium voltage-gated channel alpha subunit 11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in AV node cell action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 5 subunit alpha
Names
sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3)
sodium channel, voltage-gated, type V, alpha subunit
voltage-gated sodium channel type V alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174458.2 → NP_776883.1  sodium channel protein type 5 subunit alpha

    See identical proteins and their annotated locations for NP_776883.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ251721
    UniProtKB/TrEMBL
    F1MHP0, Q8WMP8
    Related
    ENSBTAP00000067450.2, ENSBTAT00000069888.2
    Conserved Domains (4) summary
    cd13433
    Location:1476 → 1528
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1227 → 1484
    Ion_trans; Ion transport protein
    pfam06512
    Location:958 → 1205
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:488 → 581
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    11975423..12080448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059879457.1 → XP_059735440.1  sodium channel protein type 5 subunit alpha isoform X4

  2. XM_024982393.2 → XP_024838161.1  sodium channel protein type 5 subunit alpha isoform X2

    UniProtKB/TrEMBL
    F1MHP0
    Conserved Domains (5) summary
    cd13433
    Location:1475 → 1527
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1208 → 1483
    Ion_trans; Ion transport protein
    pfam06512
    Location:958 → 1204
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:488 → 657
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1790 → 1853
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_024982396.2 → XP_024838164.1  sodium channel protein type 5 subunit alpha isoform X5

    UniProtKB/TrEMBL
    F1MHP0
    Related
    ENSBTAP00000095785.1, ENSBTAT00000134679.1
    Conserved Domains (5) summary
    cd13433
    Location:1422 → 1474
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1155 → 1430
    Ion_trans; Ion transport protein
    pfam06512
    Location:958 → 1151
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:488 → 657
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1737 → 1800
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_024982394.2 → XP_024838162.1  sodium channel protein type 5 subunit alpha isoform X3

    UniProtKB/TrEMBL
    F1MHP0
    Conserved Domains (5) summary
    cd13433
    Location:1475 → 1527
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1208 → 1483
    Ion_trans; Ion transport protein
    pfam06512
    Location:958 → 1204
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:488 → 657
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1790 → 1853
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_024982392.2 → XP_024838160.1  sodium channel protein type 5 subunit alpha isoform X1

    UniProtKB/TrEMBL
    F1MHP0
    Related
    ENSBTAP00000012068.7, ENSBTAT00000012068.7
    Conserved Domains (5) summary
    cd13433
    Location:1476 → 1528
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1209 → 1484
    Ion_trans; Ion transport protein
    pfam06512
    Location:958 → 1205
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:488 → 657
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1791 → 1854
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_024982397.1 → XP_024838165.1  sodium channel protein type 5 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A3Q1M243
    Conserved Domains (5) summary
    cd13433
    Location:1223 → 1275
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:956 → 1231
    Ion_trans; Ion transport protein
    pfam06512
    Location:705 → 952
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:235 → 404
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1538 → 1601
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein Strain
Heading Accession and Version

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